ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1621074
Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and dyslipidemia in US adults: A cross-sectional study
Provisionally accepted
- 1Department of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, China
- 2School of Clinical Medicine, Shandong Second Medical University, weifang, China
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Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with insulin resistance (IR). This study examined the relationship between estimated glucose disposal rate (eGDR), a simple IR indicator, and MASLD risk. Methods: Using NHANES 2017-2018 data (n=3,957), MASLD was diagnosed by CAP ≥285 dB/m. eGDR was calculated from waist circumference, hypertension, and HbA1c. Results: Lower eGDR significantly predicted higher MASLD risk (OR=0.396, P<0.01) and elevated CAP values (b=−21.375, P<0.01). It also correlated with unfavorable lipid profiles (lower HDL, higher triglycerides). Subgroup analyses showed consistent associations across age, sex, and diabetes status. Conclusion: eGDR was significantly associated with both MASLD and dyslipidemia. eGDR may serve as a useful indicator for identifying risk factors related to these metabolic disorders. Mediation analysis revealed that relative fat mass (RFM), (high-density lipoprotein cholesterol) HDL, triglyceride (TG), visceral adiposity index (VAI), and uric acid to HDL ratio (UHR) mediated the association between eGDR and MASLD, with respective proportions of 61.09%, 6.79%, 6.53%, 9.85%, and 12.9%.
Keywords: IR, eGDR, MASLD, Lipid, NHANES
Received: 30 Apr 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Liu, Lv, Li, Dai, Tan, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dandan Yang, Department of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Xiaoqian Zhang, Department of Gastroenterology, Affiliated Hospital of Shandong Second Medical University, Weifang, China
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