REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1650328
This article is part of the Research TopicImpact of Plant Bioactive Compounds on Human Nutrition and HealthView all articles
Beneficial Effects of Proanthocyanidins on Skin Aging: A Review
Provisionally accepted
- 1Shaanxi University of Technology, Hanzhong, China
- 2Cairo University, Giza, Egypt
- 3Ataturk Universitesi, Erzurum, Türkiye
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Skin aging is a gradual physiological process influenced by both intrinsic and environmental factors and is characterized by the appearance of wrinkles, pigmentation, reduced elasticity, dryness, and vascular changes. In recent years, interest in the use of natural bioactive compounds to mitigate skin aging has increased, reflecting the global shift toward safer, sustainable, and health-conscious skincare solutions. Proanthocyanidins (PCs), a class of polyphenolic compounds derived from plant sources, exhibit strong antioxidant, anti-inflammatory, and antipigmentation properties. These compounds have considerable potential for enhancing the structure and function of aged skin by reducing oxidative stress, promoting collagen and elastin synthesis, alleviating the skin inflammatory response, and inhibiting pigmentation. Despite their promising therapeutic value, the efficacy of PCs can be compromised by their environmental instability and low bioavailability. Advances in encapsulation techniques and combination formulations have shown promise in enhancing the stability and delivery efficiency of PCs, thereby improving their performance in antiaging applications. In conclusion, PCs offer a scientifically grounded and sustainable approach for addressing skin aging. Their integration into dermatological products represents an innovative and eco-conscious strategy for developing next-generation skincare solutions with broad health and consumer benefits.
Keywords: Proanthocyanidins (PCs), Oxidative Stress, Collagen and elastin, Inflammatory Response, Skin Pigmentation
Received: 19 Jun 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Ye, Sun, He, Ai, Jin and Abd El- Aty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Linlin He, Shaanxi University of Technology, Hanzhong, China
Wengang Jin, Shaanxi University of Technology, Hanzhong, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.