REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1651367
This article is part of the Research TopicImpact of Plant Bioactive Compounds on Human Nutrition and HealthView all 4 articles
Exploring the Anti-Aging Potential of Phytoestrogens: Focus on Molecular Mechanisms and Menopausal Symptom Modulation
Provisionally accepted
- 1School of Medicine, Jiangsu University, Zhenjiang, China
- 2Department of Traditional Chinese Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China
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The decline in estrogen levels among menopausal women can trigger multisystem dysfunction, significantly in-creasing the risk of osteoporosis, cardiovascular disease, cognitive impairment, and genitourinary syndrome (GSM). As plant-derived weak estrogen analogs, phytoestrogens demonstrate menopausal-related protective potential in preclinical studies by selectively activating ERα/ERβ/GPER receptor targets to modulate downstream signaling pathways. Current clinical trials indicate their value as an alternative strategy to menopausal hormone therapy (MHT, previously referred to as HRT) for managing menopause-related disorders. Although heterogeneity exists across study outcomes, specific formulations have shown definitive efficacy. Future well-designed, large-scale studies are warranted to validate their clinical translational potential.
Keywords: Phytoestrogens, Menopause management, estrogen receptors, Plant-derived therapeutics, clinical translation
Received: 23 Jun 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Li, Huang, Guo, Qian, Liu, Liu, Wang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qi Guo, School of Medicine, Jiangsu University, Zhenjiang, China
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