ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Sustainable Diets
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1658961
This article is part of the Research TopicCereals, Pseudocereals and Pulses: Nutritional Features and Functional Food DevelopmentView all articles
Impact of Whole Grain Interventions on Serum Vitamin D Levels in Individuals at Risk of Diabetes
Provisionally accepted
- 1National Institute for Nutrition and Health, Chinese Center For Disease Control and Prevention, Beijing, China
- 2Beijing Institute of Technology, Beijing, China
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Introduction: We examined the effects of a whole-grain intervention on serum vitamin D levels in pre-diabetic individuals in China. Methods: Participants aged 18–65 years at risk of diabetes participated in a 12-week randomised parallel controlled trial. Intervention groups consumed 50 g/d and 100 g/d of whole grains, whereas the control group maintained a regular diet. All participants received nutritional guidance. Serum 25-hydroxyvitamin D levels were monitored at baseline, 6 weeks, and 12 weeks using liquid chromatography-tandem mass spectrometry. Results: At 6 weeks, serum 25-hydroxyvitamin D levels remained insufficient across all groups. By 12 weeks, both intervention groups showed significant increases, reaching adequate levels, whereas the control group stayed at the lower limit of adequacy. Conclusion: Sustained whole grain intake improves vitamin D status in pre-diabetic individuals.
Keywords: whole grains, 25-hydroxyvitamin D, intervention, Prediabetic population, Vitamin D status
Received: 03 Jul 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Liu, wang, Ou, Feng, cheng and Gong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: zhaolong Gong, gongzl@ninh.chinacdc.cn
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