REVIEW article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1676619
This article is part of the Research TopicMicrobial Derived Metabolites as Emerging Functional Ingredients in FoodView all 3 articles
Advances in Nutritional Interventions for Coronary Heart Disease Patients from the Perspective of the Gut-Heart Axis
Provisionally accepted
- 1Jilin University, Changchun, China
- 2The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- 3Royal National Orthopaedic Hospital, London, United Kingdom
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Coronary Heart Disease (CHD) is the most common type of cardiovascular disease (CVD) and poses a heavy economic burden worldwide due to its persistently high incidence and mortality rates. In recent years, the pathogenesis of CHD is well understood, and the "gut-heart axis" theory reveals that the gut microbiota mediated dietary components enter the cardiovascular system via mechanisms including immune metabolism, epigenetics (regulation), and microbial metabolism, which can promote the formation and development of atherosclerosis. This theory identifies the gut microbiota as a promising therapeutic target for CHD intervention. The gut microbiota is highly plastic and closely related to dietary habits. Appropriate nutritional management can achieve the purpose of preventing and treating CHD. From the perspective of the "gut-heart axis", this review integrates previous research results and current research progress on the gut microbiota in CHD, summarizes the gut microbiota and related pathogenesis in CHD patients, discusses the interrelationship between CHD, nutritional management, and gut microbiota, and explores the existing problems and recent advances in nutritional management of CHD patients, which provides reference ideas for possible therapeutic strategies and precision nutrition support in CHD.
Keywords: gut-heart axis, coronary heart disease, Nursing, nutrition, Gut Microbiota
Received: 31 Jul 2025; Accepted: 23 Oct 2025.
Copyright: © 2025 Gao, Zhang, Zhang, Zhang, Zhou, Zhao and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lijing Zhao, zhao_lj@jlu.edu.cn
Yanwei Du, duyw@jlu.edu.cn
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