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REVIEW article

Front. Nutr.

Sec. Clinical Nutrition

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1682590

This article is part of the Research TopicNutraceutical Formulations and Natural Compounds for the Management of Chronic DiseasesView all 4 articles

Nutraceutical Formulations and Natural Compounds for the Management of Chronic Diseases

Provisionally accepted
  • 1ERA's Lucknow Medical College, Lucknow, India
  • 2Era University, Lucknow, India
  • 3American University of Madaba, Amman, Jordan
  • 4Qingdao University, Qingdao, China
  • 5Hokkaido Kyoiku Daigaku, Sapporo, Japan
  • 6Medical Institute, People’s Friendship University of Russia, Moscow, Russia

The final, formatted version of the article will be published soon.

Chronic non-communicable diseases including cancer, diabetes, cardiovascular, neurodegenerative, and autoimmune disorders pose mounting global health and economic challenges. Conventional drugs often focus on symptom management, frequently accompanied by side effects and rarely reversing disease progression. Nutraceuticals bioactive compounds sourced from foods, herbs, and marine organisms, offer a promising alternative due to their inherent anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, and cardioprotective properties. This review synthesizes current evidence on key nutraceutical classes (e.g., polyphenols, flavonoids, omega‑3 fatty acids, probiotics, plant alkaloids), elucidating their molecular mechanisms such as oxidative stress mitigation, immune modulation, gene regulation, and signaling pathway interactions and highlighting therapeutic applications across major chronic conditions. Addressing a critical limitation, we analyze advanced delivery technologies (e.g., nano‑formulations, encapsulation, liposomes, micro- and hydrogels, co-administered bioenhancers) designed to enhance bioavailability and targeting. We also discuss navigating hurdles such as regulatory inconsistencies, safety concerns, herb–drug interactions, and the need for standardization. To fully incorporate nutraceuticals into modern healthcare, the review emphasizes the imperative for rigorous clinical validation, manufacturing quality control, and long-term safety monitoring. Finally, we propose future directions including personalized nutraceutical strategies, AI-assisted discovery, and global regulatory harmonization positioning nutraceuticals as sustainable and evidence-based adjuncts or alternatives in chronic disease management.

Keywords: chronic diseases, Nutraceuticals, natural compounds, antioxidant, Therapeutic potential, Functional Foods, bioactive compounds, metabolic disorders

Received: 19 Aug 2025; Accepted: 30 Sep 2025.

Copyright: © 2025 Fatima, Khan, Shukla, Awaida, LI, Yamanaka and Gushchina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ghizal Fatima, ghizalfatima8@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.