CLINICAL TRIAL article
Front. Nutr.
Sec. Clinical Nutrition
Comparative Effects of MKARE® Eggshell Membrane and Hydrolyzed Collagen as Nutricosmetics on Skin Biophysical Properties: A Randomized Clinical Trial
Provisionally accepted
Yaiza González-Rodríguez1Manuel Antonio La Nuez-García2Marina Jiménez3
VEGA VILLAR-SUÁREZ1,4*
Alejandro Casado-Santos1- 1Universidad de Leon, León, Spain
- 2Arandovo SL, Noáin, Spain
- 3Lab-ex, Barcelona, Spain
- 4University of León, León, Spain
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Introduction: This study focuses on exploring the impact of fresh eggshell membrane (MKARE®) as a nutricosmetic ingredient, emphasizing its influence on skin properties. Biomechanical measurement devices were used to obtain information about the effects on the condition of the skin, comparing the results with hydrolyzed collagen and placebo. Methods: Biophysical parameters were analyzed (using Cutometer®, Tewameter®, Corneometer®, and VISIA®) in participants with skin showing signs of aging who consumed 300 mg of fresh eggshell membrane (MKARE®) or 8000 mg of hydrolyzed collagen, comparing them to a placebo group after 28 and 57 days. Results showed significant improvements in skin firmness/flexibility and elasticity after 57 days of MKARE® intake, compared to the hydrolyzed collagen and placebo groups. Conclusion: This study demonstrates that 300 mg intake of fresh membrane MKARE® positively affects mechanical skin parameters compared to the group that consumed 8000 mg of hydrolyzed collagen or the placebo group. These improvements suggest that MKARE® consumption regenerates the skin structure, primarily due to positive changes in collagen and elastin formation, which are key contributors to the improvement of skin firmness, elasticity and barrier protection.
Keywords: Corneometer®, Cutometer®, Eggshell membrane, Hydrolyzed collagen, Skin elasticity, SkinFlexibility, Tewameter®, TEWL
Received: 20 Aug 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 González-Rodríguez, La Nuez-García, Jiménez, VILLAR-SUÁREZ and Casado-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: VEGA VILLAR-SUÁREZ
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.