ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Immunology
This article is part of the Research TopicHealth Effects of Natural Compounds from PlantsView all 23 articles
Antroquinonol Reduces IL-1β Production in Macrophages Through Enhancing the DNA Methylation of Tlr4
Provisionally accepted
- 1South China Agricultural University, Guangzhou, China
- 2Anyou Biotechnology Group Co. LTD, Taicang, China
- 3Changsha Medical University, Changsha, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Emerging studies revealed that numerous plant-or fungal-derived extracts significantly modulate immune responses. Antroquinonol (Antro), a characteristic triterpenoid compound isolated from Antrodia camphorata, has been extensively documented for its anti-inflammatory properties, but the precise mechanisms remain unclear. In this study, we established a macrophage polarization model in vitro to evaluate the impact of Antro on macrophage polarization. Our findings demonstrate that Antro enhances the enzymatic activities of DNA methyltransferases and facilitates DNA methylation-mediated suppression of Tlr4 expression, thereby inhibiting NF-κB signaling, ultimately attenuating IL-1β production in macrophages. Our study elucidates the anti-inflammatory effects of Antro, which significantly enriches the theoretical framework of natural product-mediated immunomodulation (particularly plant/fungal extracts). These findings provide critical scientific support for developing A. camphorata-derived products as novel food or feed additives to elevate immune function.
Keywords: Antrodia camphorata, Antroquinonol, macrophage, DNA Methylation, IL-1β
Received: 09 Nov 2025; Accepted: 01 Dec 2025.
Copyright: © 2025 Peng, Fu, Wang, Hung, Liu, Peng and Mo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Peng
Jiahao Mo
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.