ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Associations of the composite dietary antioxidant index with all-cause mortality among individuals with psoriasis: a population-based study
Provisionally accepted
- Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
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Background: The composite dietary antioxidant index (CDAI) is an effective indicator to evaluate the comprehensive intake of dietary antioxidants in individuals. There is growing evidence suggesting that higher CDAI levels are associated with a reduced risk of diverse health conditions such as hypertension and atherosclerotic cardiovascular disease, as well as with lower mortality risk among the general public. However, its impact on the mortality risk of patients with psoriasis remains unclear. This study aimed to investigate the potential association between CDAI and the risk of death in individuals with psoriasis. Methods: Data extracted from the National Health and Nutrition Examination Survey (NHANES) spanning 2003-2006 and 2009-2014 was enrolled in this research, with mortality data obtained from the National Death Index (NDI) database. We utilized Multivariate COX proportional hazard regression models to investigate the influence of CDAI levels on the death risk from all causes among individuals with psoriasis. We further performed subgroup and sensitivity analyses to verify the reliability of the results. Results: 500 patients with psoriasis were finally enrolled in this prospective study. During the follow-up period, 61 deaths occurred. CDAI levels were linked to a reduced death risk in patients with psoriasis, compared to the lowest tertile, the hazard ratios for all-cause mortality were 0.48 (95% CI: 0.20– 1.17, P = 0.105) for tertile 2 and 0.30 (95% CI: 0.12–0.74, P = 0.009) for tertile 3. Conclusion: Our study found that higher CDAI levels were associated with lower all-cause mortality in patients with psoriasis. Further prospective studies are needed to confirm the role of CDAI in mortality risk in patients with psoriasis.
Keywords: Composite Dietary Antioxidant Index, Mortality, NHANES, Oxidative Stress, Psoriasis
Received: 16 Mar 2025; Accepted: 26 Jan 2026.
Copyright: © 2026 Li, Su, Tang and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuan Li
Yanling He
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