REVIEW article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
This article is part of the Research TopicThe Foundational Components and Elements of Plant Foods for Neurological Nutrition and Well-beingView all 17 articles
Plant-Derived Nutritional Components in Thyroid Disease-Related 1 Neuropsychiatric Disorders: Mechanistic Insights and Advances 2
Provisionally accepted
- 1Nanjing University of Chinese Medicine, Nanjing, China
- 2Department of Endocrinology，Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, nanjing, China
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Abstract 41 Plant-derived nutritional components represent a promising adjunctive strategy for 42 addressing neuropsychiatric manifestations of thyroid disorders. Although 43 conventional hormone replacement normalizes biochemical parameters, many patients 44 continue to experience neurocognitive impairment and affective symptoms, 45 underscoring the complexity of thyroid–brain axis regulation. This review synthesizes 46 recent advances on how plant-based nutritional approaches may modulate oxidative 47 stress, neuroinflammation, neurotransmitter homeostasis, and blood–brain barrier 48 integrity, and evaluates their emerging clinical applicability and existing evidence 49 gaps. Overall, plant-based interventions may complement standard therapy and 50 improve neuropsychiatric outcomes, though larger prospective studies are needed to 51 clarify their efficacy and identify suitable patient subgroups.
Keywords: Cognitive Function, Neuroinflammation, Oxidativestress, plant-based nutrition, Thyroid–brain axis
Received: 30 Aug 2025; Accepted: 26 Jan 2026.
Copyright: © 2026 Zhang, Xu, Wang, Shen, Sun, Zha and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zihan Zhang
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