Frontiers in Oncology | Cancer Molecular Targets and Therapeutics

Original Research

Published on 30 Apr 2025

Safety and efficacy of apatinib in combination treatment versus apatinib as second-line treatment for advanced gastric cancer

in Cancer Molecular Targets and Therapeutics

Zhang Han
Zhu Yuanzeng
Wu Gang
Sun Peichun

Frontiers in Oncology

doi 10.3389/fonc.2025.1587069

664 views

Original Research

Published on 30 Apr 2025

Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value

in Cancer Molecular Targets and Therapeutics

Naoko Hattori
Hironori Takamatsu
Naoko Iida
Naofumi Asano
Satoshi Yamashita
Gina Miku Oba
Kozue Kimura
Akihiko Yoshida
Eisuke Kobayashi
Robert Nakayama

Frontiers in Oncology

doi 10.3389/fonc.2025.1419877

867 views

Original Research

Published on 29 Apr 2025

LSM2 drives glioma progression through alternative splicing dysregulation: a multi-omics approach to identify a potential therapeutic target

in Cancer Molecular Targets and Therapeutics

Cao Yang
Chang Ge
Wenjie Zhang
Jingxuan Xu

Frontiers in Oncology

doi 10.3389/fonc.2025.1521608

813 views

Case Report

Published on 29 Apr 2025

Copy number gain of MET gene with low level in a metastatic lung adenocarcinoma patient represents response to salvage treatment with savolitinib and osimertinib: a case report

in Cancer Molecular Targets and Therapeutics

Jian Wang
Xinying Dong
Yangxin Liu
Keying Lin
Jianxin Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1507677

569 views

Review

Published on 28 Apr 2025

Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications

in Cancer Molecular Targets and Therapeutics

Bunty Sharma
Himanshu Shekhar
Anidrisha Sahu
Damandeep Kaur
Shafiul Haque
Hardeep Singh Tuli
Himanshu Sharma
Ujjawal Sharma

Frontiers in Oncology

doi 10.3389/fonc.2025.1570193

987 views

Original Research

Published on 28 Apr 2025

Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study

in Cancer Molecular Targets and Therapeutics

Jian Wang
Feiyang Yuan
Mahadevi Kendre
Zhijin He
Shaowei Dong
Abhinandan Patil
Kausing Padvi

Frontiers in Oncology

doi 10.3389/fonc.2025.1590779

996 views

Review

Published on 25 Apr 2025

Dual roles of methylglyoxal in cancer

in Cancer Molecular Targets and Therapeutics

Zongao Wang
Shaojun Liu
Minghui Zhang
Min Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1557162

862 views

Review

Published on 25 Apr 2025

Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis

in Cancer Molecular Targets and Therapeutics

Hanhui Jing
Yan Gao
Linyuan Jing
Hanyu Yang
Shanglong Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1489701

861 views

Original Research

Published on 24 Apr 2025

Expression of SMURF family in pancreatic cancer and its effect on cell proliferation and migration

in Cancer Molecular Targets and Therapeutics

Chen Zhang
Caoyi Li
Long Wu
Yuan Wang
Ke Huang
Xu Yang
Sai Zhao
Haoran Zhu
Lin Shi
Jian Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1538335

690 views

Mini Review

Accepted on 22 Apr 2025

Advancing Targeted Therapy for Colorectal Cancer: Harnessing Ligand-Directed Enzyme Prodrug Therapy (LDEPT) for Highly Specific Interventions

in Cancer Molecular Targets and Therapeutics

Hend Al-Jaber
Kabir H Biswas
Layla Al-Mansoori

Frontiers in Oncology

doi 10.3389/fonc.2025.1570712

193 views

Review

Accepted on 18 Apr 2025

Nanomaterials Targeting Cancer Stem Cells to Overcome Drug Resistance and Tumor Recurrence

in Cancer Molecular Targets and Therapeutics

DIVYA VISHAMBHAR KUMBHAKAR
Lucky Thakkar
Chetana Akhand
Shehna Sharaf
Geeta K Vemuganti

Frontiers in Oncology

doi 10.3389/fonc.2025.1499283

283 views

Original Research

Published on 17 Apr 2025

Development and validation of a prognostic model for post-surgical overall survival in Asian colon cancer patients: a real-world population-based study

in Cancer Molecular Targets and Therapeutics

Cheng Liu
Huaide Qiu
Junqiang Wang
Min Yang
Zhixiang Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1541561

853 views

Original Research

Accepted on 15 Apr 2025

Impact of thymoquinone on Nrf2/HO-1 and MAPK/NFkBNF-κB axis in mitigating 5-Flurouracil induced acute kidney injury in vivo

in Cancer Molecular Targets and Therapeutics

Summya Rashid

Frontiers in Oncology

doi 10.3389/fonc.2025.1572095

151 views

Review

Published on 15 Apr 2025

The role and clinical significance of tumor-associated macrophages in the epithelial–mesenchymal transition of lung cancer

in Cancer Molecular Targets and Therapeutics

Lei Liao
Ying-Xia Wang
Su-Su Fan
Ying-Yue Hu
Xue-Chang Wang
Xuan Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1571583

1,244 views

Original Research

Published on 15 Apr 2025

Tumor-associated macrophages correlate with better outcome in SHH medulloblastoma

in Cancer Molecular Targets and Therapeutics

Jin Zhang
Shuting Li
Yuan Wang
Jingjing Liu
Yan Liu
Xiaojun Gong
Yanling Sun
Liming Sun
Zhigang Li
Tianyou Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1557313

872 views

Brief Research Report

Published on 15 Apr 2025

Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A

in Cancer Molecular Targets and Therapeutics

Christopher A. Galifi
Ryan J. Dikdan
Divyangi Kantak
Joseph J. Bulatowicz
Krystopher Maingrette
Samuel I. Gunderson
Teresa L. Wood

Frontiers in Oncology

doi 10.3389/fonc.2025.1563985

1,092 views