Frontiers in Pharmacology | Renal Pharmacology

Original Research

Accepted on 12 Feb 2026

IR-780 Improves Urination Function and Complications in Rats with Partial Bladder Outlet Obstruction by Protecting Bladder Smooth Muscle Cell Mitochondria from Oxidative Stress

in Renal Pharmacology

Feng Pi
Benhuang Yan
Min Jia
Yuan Liu
Shuang Tang
Zhihong Huang
Qiang Fang
Chunmeng Shi
Weibing Li

Frontiers in Pharmacology

Original Research

Accepted on 11 Feb 2026

Huangkui Capsule Mitigates Diabetic Nephropathy via Epigenetic Therapy Effects

in Renal Pharmacology

Yihong Yu
Haitao Tang
Nan Li
Haitao Ge
Jie Wu
Harvest F Gu

Frontiers in Pharmacology

173 views

Correction

Accepted on 09 Feb 2026

Correction: Erythropoietin Mitigates Diabetic Nephropathy by Restoring PINK1/Parkin-Mediated Mitophagy

in Renal Pharmacology

Xinyao Yi
Yan Wenhui
Tingli Guo
Na Liu
Zhuanzhuan Wang
Jia Shang
Xiaotong Wei
Xin Cui
Yuzhuo Sun
Shuting Ren

Frontiers in Pharmacology

Original Research

Published on 09 Feb 2026

Minnelide ameliorates Col4a5+/− mice by upregulating Col4a5 and alleviating endoplasmic reticulum stress

in Renal Pharmacology

Bao-wei Ji
Jun-chao Liu
Xue Wang
Ye Yin
Jing-jia Zhang
Fu-jie Wen
Hong Xu
Qian Shen
Jian Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1761502

376 views

Original Research

Accepted on 05 Feb 2026

Finerenone Is Associated with Pronounced Uric Acid Reduction in Hyperuricemic Diabetic Kidney Disease: A Real-World Analysis

in Renal Pharmacology

Yanm Lin
Jianqing Tian
Bo Liu
Kang Du

Frontiers in Pharmacology

175 views

Original Research

Published on 30 Jan 2026

A new Jun amino-terminal kinase inhibitor, KRev-202, inhibits rat ischemic acute injury and the progression to renal fibrosis

in Renal Pharmacology

David J. Nikolic-Paterson
Greg H. Tesch
Elyce Ozols
Kurt Jarnagin
Yoshi Satoh
David R. Webb
Elizabeth Squiers
Keren Grynberg
Frank Y. Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667221

432 views

Original Research

Published on 30 Jan 2026

RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206+ macrophages

in Renal Pharmacology

Hualin Cao
Xiaoye Chen
Ruyue Jin
Yunjie Yang
Yuandong Tao
Pin Li
Yangyang Wu
Guilong Chen
Jiawen Zhao
Jianhua Wen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1739457

565 views

Systematic Review

Accepted on 28 Jan 2026

Effects of rutin on renal function, oxidative stress and fibrosis in animal models of diabetic nephropathy: a systematic review and meta-analysis

in Renal Pharmacology

Zongtao Li
Yashi Wang
Die Fang
Yiman Wang
Hongzhe Han
Xueqin Zhang
Zhiqiang Chen

Frontiers in Pharmacology

186 views

Original Research

Published on 26 Jan 2026

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk

in Renal Pharmacology

Yue Tu
Wenjie Liu
Tianqing Sang
Liuyunxin Pan
Wei Wu
Qijun Fang
Yinglu Liu
Buhui Liu
Yigang Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1693000

669 views

Review

Published on 23 Jan 2026

Improving kidney transplantation through the addition of pharmacological agents to hypothermic preservation solutions: a scoping review

in Renal Pharmacology

Vincent Mayoral
Tom Darius
Sarah Bruneau
Christophe Masset
Jérôme Rigaud
Gilles Blancho
Thomas Prudhomme
Julien Branchereau
Benoît Mesnard

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692398

690 views

General Commentary

Published on 21 Jan 2026

Commentary: Effect of injecting adipose stem cells combined with platelet-rich fibrin releasate at Shenshu acupoint (BL23) on acute kidney injury in rabbits

in Renal Pharmacology

Xun Zheng
Ruoru Yu
Cheng Feng
Lei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743787

481 views

Original Research

Accepted on 14 Jan 2026

Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in rat lethal and sublethal models of Hemolytic Uremic Syndrome

in Renal Pharmacology

Daiana S Sánchez
Lilian K Fischer Sigel
Elsa Zotta
Claudia Silberstein

Frontiers in Pharmacology

194 views

Original Research

Published on 14 Jan 2026

High glucose-induced PLCG1 histone acetylation to promote ferroptosis by LAMP2A/HSPA8 in a diabetic nephropathy model

in Renal Pharmacology

Jun Ge
Zhenzhen Wang
Ting Xu
Ruifeng Jiang
Xuefeng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640721

800 views

Original Research

Published on 12 Jan 2026

Insulin restores renal neprilysin (NEP) and attenuates the shedding of urinary NEP and KIM-1 in diabetic Akita mice

in Renal Pharmacology

Rupinder K. Gill
Esam S. B. Salem
Nadja Grobe
Khalid M. Elased

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679651

779 views

Original Research

Published on 12 Jan 2026

Dual blockade of DPP-4 and CXCL12/CXCR4 axes synergistically protects podocytes in lupus nephritis

in Renal Pharmacology

Hui-miao Hu
Yong-chun Li
Yang-ming Zhang
Teng-yu Zhu
Wei-jing Yong
Yu-hui Gan
Chen Liu
Rui-ying Duan
Hong-de Xu
Zhan-zheng Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732243

994 views

Original Research

Published on 07 Jan 2026

Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validation

in Renal Pharmacology

Lili Cheng
Zhongfu Tang
Ming Li
Chuanbing Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726254

1,233 views

Review

Published on 07 Jan 2026

Roxadustat for renal anemia: current clinical experience

in Renal Pharmacology

Jialing Ji
Zhongtang Li
Shuping Fang
Zuolin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712869

1,412 views

Review

Published on 06 Jan 2026

Unraveling the role of mitochondrial dysfunction in diabetic kidney disease: insights and interventions

in Renal Pharmacology

Zhenliang Fan
Puchang Luo
Yuancheng Gao
Hongzhen Ma
Junfen Fan
Shriya Sanan
Peipei Zhang
Keda Lu
Hong Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1618418

1,148 views

Correction

Published on 02 Jan 2026

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

in Renal Pharmacology

Weili Liao
Rui Fan
Yuman Du
Hairong Wang
Yong Yang
Yuan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1764700

564 views

Original Research

Published on 18 Dec 2025

Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats

in Renal Pharmacology

Liang Sun
Xiaoran Ma
Yuhui Jiang
Wanda Zhang
Yi Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686334

1,172 views

Original Research

Published on 18 Dec 2025

Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation

in Renal Pharmacology

Juntao Wang
Ruifeng Li
Xiaofei Fu
Shuai Huo
Lijiao Wang
Fengmin Shao
Yue Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686323

863 views

Original Research

Published on 18 Dec 2025

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

in Renal Pharmacology

Stefano Turolo
Alberto Edefonti
Marie-Louise Syren
Anita S. Bellotti
William Morello
Federica Collino
Carlo Agostoni
Giovanni Montini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672304

1,145 views

Review

Published on 18 Dec 2025

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

in Renal Pharmacology

Jiahuan Gong
Xingxing Fang
Xinlei Yao
Fei Xue
Guangdong Qi
Bingqian Chen
Hualin Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729941

1,995 views

Correction

Published on 15 Dec 2025

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity

in Renal Pharmacology

Hui-Fang Deng
Lan-Xin Yue
Ning-Ning Wang
Yong-Qiang Zhou
Wei Zhou
Xian Liu
Yu-Hao Ni
Cong-Shu Huang
Li-Zhen Qiu
Hong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734058

658 views

733 articles

articles

IR-780 Improves Urination Function and Complications in Rats with Partial Bladder Outlet Obstruction by Protecting Bladder Smooth Muscle Cell Mitochondria from Oxidative Stress

Huangkui Capsule Mitigates Diabetic Nephropathy via Epigenetic Therapy Effects

Correction: Erythropoietin Mitigates Diabetic Nephropathy by Restoring PINK1/Parkin-Mediated Mitophagy

Minnelide ameliorates Col4a5+/− mice by upregulating Col4a5 and alleviating endoplasmic reticulum stress

Finerenone Is Associated with Pronounced Uric Acid Reduction in Hyperuricemic Diabetic Kidney Disease: A Real-World Analysis

A new Jun amino-terminal kinase inhibitor, KRev-202, inhibits rat ischemic acute injury and the progression to renal fibrosis

RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206+ macrophages

Effects of rutin on renal function, oxidative stress and fibrosis in animal models of diabetic nephropathy: a systematic review and meta-analysis

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk

Improving kidney transplantation through the addition of pharmacological agents to hypothermic preservation solutions: a scoping review

Commentary: Effect of injecting adipose stem cells combined with platelet-rich fibrin releasate at Shenshu acupoint (BL23) on acute kidney injury in rabbits

Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in rat lethal and sublethal models of Hemolytic Uremic Syndrome

High glucose-induced PLCG1 histone acetylation to promote ferroptosis by LAMP2A/HSPA8 in a diabetic nephropathy model

Insulin restores renal neprilysin (NEP) and attenuates the shedding of urinary NEP and KIM-1 in diabetic Akita mice

Dual blockade of DPP-4 and CXCL12/CXCR4 axes synergistically protects podocytes in lupus nephritis

Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validation

Roxadustat for renal anemia: current clinical experience

Unraveling the role of mitochondrial dysfunction in diabetic kidney disease: insights and interventions

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats

Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity