Frontiers in Pharmacology | Translational Pharmacology

Original Research

Published on 14 May 2025

A novel adenosine-to-inosine RNA editing-based nomogram for predicting prognosis of hepatocellular carcinoma

in Translational Pharmacology

Shiqiong Huang
Ji Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547320

268 views

Review

Published on 14 May 2025

BCAA metabolism in cancer progression and therapy resistance: The balance between fuel and cell signaling

in Translational Pharmacology

Yi Zhou
Jiahui Kou
Wenjin Li
Yuyao Wang
Xingxing Su
Hongguang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595176

452 views

Mini Review

Published on 13 May 2025

Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities

in Translational Pharmacology

Weiyan Shi
Zhiqiang Yang
Pengbin Fu
Yang Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569020

358 views

Original Research

Accepted on 12 May 2025

Functionalized Turmeric Nanovesicles for Precision Delivery of Doxorubicin in Colorectal Carcinoma Treatment

in Translational Pharmacology

Chen Meng
xue Yi
Duan Meitao
Ahmed Mahal
Zhiqiang Zhang
Jungang Ren
Ming Chen
Lin Yang
Moxun Xu
Ahmad J Obaidullah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587560

Original Research

Accepted on 05 May 2025

The glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery

in Translational Pharmacology

Mariel Molina-Castro
Blair Rowitz
Marta Yanina Pepino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575156

Clinical Trial

Published on 02 May 2025

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson’s disease

in Translational Pharmacology

Hayam Ali AlRasheed
Mostafa M. Bahaa
Thanaa A. Elmasry
Eman I. Elberri
Fedaa A. Kotkata
Ramy M. El Sabaa
Yasmine M. Elmorsi
Mostafa M. Kamel
Walaa A. Negm
Amir O. Hamouda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1497261

679 views

Original Research

Published on 28 Apr 2025

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology

in Translational Pharmacology

Xuejing Zhu
Lei Zhang
Wenqian Cui
Liangjie Wang
Fengjing Xu
Mengyuan Liu
Shuangcheng Chen
Haowen Jiang
Zhiying He
Chang Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567639

651 views

Original Research

Published on 25 Apr 2025

Tacrolimus exposure during the three-month period following allogeneic stem cell transplantation predicts overall survival

in Translational Pharmacology

Alzbeta Zavrelova
Katerina Zibridova
Jakub Radocha
Eva Cermakova
Petra Rozsivalova
Pavel Zak
Benjamin Visek
Miriam Lanska
Jana Stevkova
Sara Merdita

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517083

705 views

Original Research

Accepted on 23 Apr 2025

Zabedosertib, a novel interleukin-1 receptor-associated kinase-4 inhibitor, shows a favorable pharmacokinetic and safety profile across multiple phase 1 studies

in Translational Pharmacology

Maximilian Feldmüller
Stefan J Jodl
Bart Ploeger
Andrea Wagenfeld
Herbert Wiesinger
Frank S Zollmann
Stefan Klein
Ruiping Zhang
Beate Rohde
Joachim Höchel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521505

228 views

Review

Published on 22 Apr 2025

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

in Translational Pharmacology

Ping Nie
Minghua Wang
Yan Mo
Hong Zhou
Qingbing Zha
Gendie E. Lash
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526709

1,468 views

Original Research

Published on 14 Apr 2025

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

in Translational Pharmacology

Lorenzo Flori
Giulia Galgani
Giorgia Bray
Chiara Ippolito
Cristina Segnani
Carolina Pellegrini
Valentina Citi
Nunzia Bernardini
Alma Martelli
Vincenzo Calderone

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546456

1,159 views

Original Research

Published on 11 Apr 2025

Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier

in Translational Pharmacology

Sheng Ding
Yinghua Wei
Minglong Yang
Jinyi Shi
Kaiyuan Ren
Xinli Li
Zhuo Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589150

794 views

Original Research

Published on 10 Apr 2025

Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa

in Translational Pharmacology

Haoan He
Chao Lv
Yuhong Xie
Wei Li
Zihang Ling
Bin Cheng
Xiaoan Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559584

928 views

Original Research

Published on 09 Apr 2025

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations

in Translational Pharmacology

Abdul Mateen
Abad Khan
Ismail Khan
Saifullah Khan Khalil
Lateef Ahmad
Muhammad Junaid
Saqib Jehan
Muhammad Sohail Anwar
Muhammad Faheem
Abdul Salam

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1442762

811 views

Systematic Review

Published on 04 Apr 2025

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis

in Translational Pharmacology

Xu Zhao
Xianhao Huo
Yizhen Meng
Ran Zhao
Xiaozhuo Liu
Jiancheng Chen
Zhiqi Mao
Mei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529647

1,570 views

Original Research

Published on 04 Apr 2025

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

in Translational Pharmacology

Wang Yu
Su Jie
Gao Su
Niu Zhuangwei
Zhou Yiqing
Chen Suhong
Lv Guiyuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550357

1,018 views