Frontiers in Pharmacology | Translational Pharmacology

Original Research

Published on 19 Nov 2025

Metabolomic changes associated with treatment response of neoadjuvant chemotherapy with TEC regimen in HER2-negative breast cancer

in Translational Pharmacology

Kun Fang
Cuiping Wang
Zhenfeng Li
Li Wang
Xintong Wang
Zhenwei Jiang
Mengyuan Wu
Shuo Diao
Mingming Yu
Hai Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707223

173 views

Mini Review

Published on 19 Nov 2025

Targeting emerging amino acid dependencies and transporters in cancer therapy

in Translational Pharmacology

Alfred Akinlalu
Emmanuel Ogberefor
Tommy Gao
Dali Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1717414

235 views

Original Research

Accepted on 18 Nov 2025

Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling 1 pathway and prevents postmenopausal osteoporosis

in Translational Pharmacology

Shengfa Li
Peili Liang
Jian Chen
Youming Zhang
Haixiong Miao
Ting Wang

Frontiers in Pharmacology

Perspective

Published on 18 Nov 2025

Radioprotection redefined: drug discovery at the intersection of tardigrade biology and translational pharmacology

in Translational Pharmacology

Zhitao Cui
Cong Lin
Huiying Zhao
Xiaohui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713914

227 views

Original Research

Accepted on 17 Nov 2025

Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation

in Translational Pharmacology

Letizia Spataro
Maurizio Ragni
Agnese Segala
Alice Vetturi
Giulia Sofia Marcotto
Luca Canciani
Michele Olivo Carruba
Roberto Aquilani
Ginetta Collo
Alessandra Valerio

Frontiers in Pharmacology

Review

Published on 17 Nov 2025

An overview of the mechanistic approaches of antifungal nanomaterials

in Translational Pharmacology

Sarmistha Saha
Nadezhda Sachivkina
Regina Gurina
Ekaterina Neborak
Natallia Zhabo
Marina Avdonina
Maria Molchanova

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701446

605 views

Review

Published on 14 Nov 2025

Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation

in Translational Pharmacology

Hany N. Azzam
Ahmed M. El-Dessouki
Kareem A. Attallah
Mohamed A. Sadek
Yara M. Aboulmagd
Mennat-Allah M. Hassan
Mohamed I. Fahmy
Riham A. El-Shiekh
Rania M. Kamal
Hazim O. Khalifa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704535

491 views

Opinion

Published on 13 Nov 2025

Bridging bench to bedside: a dual-use framework for chromene-based anti-obesity and antiviral therapeutics

in Translational Pharmacology

Sigrit Karla Chávez-Jiménez
Carlos Josué Solórzano-Mata
Beatriz Xóchitl Ávila-Curiel
Efrén Emmanuel Jarquín González
Edgar Zenteno
Hector A. Cabrera-Fuentes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666414

792 views

Case Report

Accepted on 10 Nov 2025

A Pharmacist-Led Precision Therapy Framework for Managing Invasive Fungal Infection in CSF1R-Related Leukoencephalopathy Post Allo-HSCT

in Translational Pharmacology

JIN LU
Mengqi Jia
Xinghua Luan
Zhongqiu Zhang
Jingying Wu
Xincai Zhao
Miaomiao Zhou
Yao Fu
Quanjun Yang
Li Cao

Frontiers in Pharmacology

189 views

Clinical Trial

Accepted on 10 Nov 2025

Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study

in Translational Pharmacology

Hongzhong Liu
Tao Liu
Ming Liu
Xin Zheng
Wen Zhong
Qian Zhao
Ji Jiang
Pei Hu
Yishi Li

Frontiers in Pharmacology

143 views

Original Research

Accepted on 10 Nov 2025

Intraoperative dexmedetomidine use associated with prolonged postanesthesia care unit recovery time after lung resection: a retrospective cohort study

in Translational Pharmacology

Zhenglian Gao
Yan Jiang
Yixin Liu
Chang Yang
Bangjian Zhang
Ming Li

Frontiers in Pharmacology

100 views

Brief Research Report

Published on 10 Nov 2025

Liposomal-synthetic-cannabidiol: preliminary translational evidence of efficacy, tolerability and pharmacokinetics following repeated subcutaneous injections in two goats

in Translational Pharmacology

Yael Shilo-Benjamini
Wiessam Abu Ahmad
Dinorah Barasch
Eran Lavy
Daniel Zilbersheid
Yechezkel Barenholz
Ahuva Cern

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689226

550 views

Review

Published on 07 Nov 2025

Mitochondrial involvement in PC: improving therapeutic strategies

in Translational Pharmacology

Jiaxin Zhang
Chang Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710923

821 views

Original Research

Published on 06 Nov 2025

In-depth analysis for TKI-driven real-world management of 201 CML patients using TFR

in Translational Pharmacology

Mihnea Lucian Micu
Simion Florin Cira
Mihnea Zdrenghea
Anca Bojan
Andrada Parvu
Tunde Torok-Vistai
Anca Vasilache
Laura Urian
Bancos Anamaria
Laura Ioana Jimbu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673056

967 views

Original Research

Published on 06 Nov 2025

Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models

in Translational Pharmacology

Francesca Bompan
Giada Lodi
Rebecca Foschi
Anna Dipinto
Lucia Carmela Cosenza
Fabio Casciano
Paolo Severi
Anna Sanvido
Lorenzo Caruso
Luisa Giari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692250

456 views

Clinical Trial

Published on 05 Nov 2025

Combination of remazolam and alfentanil on hemodynamics, postoperative cognitive function, and adverse cardiovascular events in elderly patients undergoing laparoscopic cholecystectomy: a randomized controlled trial

in Translational Pharmacology

Chaolei Liu
Jin Li
Junna He
Jingjing Zhang
Lijun Bo
Jiaojiao Yang
Yuan Ma
Jianzhang Qin
Yanjie Yang
Zhangnan Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653593

476 views