Measurement of Glioma Electrical Properties for Data-Driven Electrical Properties Tomography

Chunyou Ye¹Yaqing Jia¹Weiwei Chen²Guanfu Li¹Wenxia Ju¹Xiaoxing Huang³Xin Li¹Fang He^3*Jijun Han^1*

• ¹Anhui Medical University, Hefei, China
• ²Department of Neurosurgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China
• ³Hefei BOE Hospital, Hefei, Anhui Province, China

Electrical properties (EPs) are widely used to assign values to electromagnetic simulation models, providing the comprehensive datasets needed for data-driven electrical properties tomography (EPT) reconstruction. However, the key limitations in current research on glioma EPs are the small sample sizes and the lack of EPs at certain Larmor frequencies. Therefore, this study aims to provide accurate glioma EPs in full frequency range for EPT. We measured 128 samples, including 81 gliomas and 47 adjacent surrounding tissues, in the frequency range of 50 MHz to 4 GHz using an open-ended coaxial probe (OCP) method. The accuracy of our measurements was verified through uncertainty analysis. Using the Cole-Cole model, we obtained the EPs across the full frequency spectrum. Subsequently, we developed a human simulation model to evaluate the impact of different EPs on the simulated B1 field. At frequencies of 64 MHz, 128 MHz, 213 MHz, and 298 MHz, the model was assigned either the EPs measured in this study or those reported in the literature, and the relative differences in the simulated fields were calculated. We first analyzed the discrepancies between our measured EPs and those from previous studies. The results suggested that small sample sizes may introduce bias, potentially compromising the reliability of the findings. Moreover, interpolated data may fail to reflect the frequency-dependent behavior of EPs, leading to reduced accuracy. Simulation results indicate that differences in EPs can lead to measurable deviations in magnetic field simulations. This variation in the 𝐵 1 + field in response to EPs is critical for enabling accurate EPs reconstruction. It also underscores the importance of precise EPs measurements, as errors in the training dataset may compromise the performance of models. Therefore, the reliable EPs of glioma provided in this study have the potential to enhance the accuracy of data-driven EPT, thereby assisting clinical diagnosis and treatment.