Frontiers in Toxicology

Original Research

Published on 10 Feb 2026

Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells

in In Vitro Toxicology

Anani K. Afanou
Andreas Solberg Sagen
Francesco Barbero
Ilaria Zanoni
Anna Costa
Øyvind P. Haugen
Shan Zienolddiny-Narui

Frontiers in Toxicology

doi 10.3389/ftox.2026.1718466

298 views

Original Research

Accepted on 09 Feb 2026

Ecotoxicological Thresholds of Glyphosate: Linking Sub-Lethal Exposure to Liver Tissue Damage and Behavioural Disturbances in African Catfish

in Environmental Toxicology

Bethel Uchenna Udume
Anyaele Uka
Glory Nnenna Oji
Chieze Precious Chikezie
Chidi Onyewuchi
Obiahu Henry Ota

Frontiers in Toxicology

Original Research

Accepted on 09 Feb 2026

Protective Effects of Lagerstroemia speciosa Against Paracetamol-Induced Renal and Testicular Toxicity in Rats via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

in Regulatory Toxicology

Nagham E. Elsheshtawy
Engy Risha
Fatma M. Abdelhamid
Bodour Rajab
Rehab Bagadood
Bayan Bokhari
Ghadir Sindi
Ahmed I. Ateya
Shimaa Rezk
Mohamed El-Boshy

Frontiers in Toxicology

Mini Review

Published on 09 Feb 2026

From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round

in Developmental and Reproductive Toxicology

Celia Garcia Arenas
Kiara Aiello Holden
Terje Svingen
Dries Knapen
Saadia Kerdine-Römer
Birgitte Lindeman
Nicola M. Smith
Ludovic Le Hegarat
Tamara Vanhaecke
Gilles Rivière

Frontiers in Toxicology

doi 10.3389/ftox.2026.1746437

432 views

Review

Accepted on 05 Feb 2026

Exploring Ethical, Sustainable and Effective Foetal Bovine Serum Alternatives for In Vitro Mammalian Cell Culture

in In Vitro Toxicology

Huiyuan Meng
Philip J.R. Day

Frontiers in Toxicology

125 views

Mini Review

Published on 05 Feb 2026

Microplastic toxicity: mechanisms, assessment methods, and future research directions

in Nanotoxicology

Yifan Zhang
Jiale Ren
Binying Zheng
Jiefang Sun
Jing Zhang
Yumin Niu
Bing Shao
Yushen Jin

Frontiers in Toxicology

doi 10.3389/ftox.2026.1766103

526 views

Brief Research Report

Published on 05 Feb 2026

A case report of arsenic-induced peripheral neuropathy misdiagnosed as Guillain-Barré syndrome

in Clinical Toxicology

Shanshan Fu
Guanao Wu
Yibo Zhan
Hui Xia
Chang Zhou
Jingjing Zeng
Ye Tang
Boyan Pan
Zequan Zheng
Min Zhao

Frontiers in Toxicology

doi 10.3389/ftox.2026.1722489

389 views

Perspective

Published on 04 Feb 2026

Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation

in In Vitro Toxicology

Tom Meseberg
Susanne Kurz
Juliane Spohn

Frontiers in Toxicology

doi 10.3389/ftox.2026.1735871

695 views

Original Research

Published on 04 Feb 2026

Multi-task deep learning models for mechanism-based prediction of developmental and reproductive toxicity (DART) using ToxCast bioassays

in In Vitro Toxicology

Siyeol Ahn
Hojun Jung
Jinwon Hwang
Donghyeon Kim
Hyunjun Kim
Wooseok Kim
Yunjung Lee
Changwon Lim
Jinhee Choi

Frontiers in Toxicology

doi 10.3389/ftox.2026.1751644

874 views

Original Research

Published on 04 Feb 2026

Clinical features of toxic encephalopathy induced by 1,2-dichloroethane

in Clinical Toxicology

Yuquan Chen
Yuqiang Lin
Yifan Ye
Meiwen Xie
Jiaqi Chen
Zhiqian Yang
Zhi Wang

Frontiers in Toxicology

doi 10.3389/ftox.2026.1683456

265 views

Review

Published on 03 Feb 2026

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption – a PARC project

in Developmental and Reproductive Toxicology

Jacob Ardenkjær-Skinnerup
Yoni Baert
Lola Bajard
Jonathan Blum
François Brion
Lucia Coppola
Jean-Baptiste Fini
Ellen Fritsche
Henrik Holbech
Selma Hurem

Frontiers in Toxicology

doi 10.3389/ftox.2026.1736963

1,020 views

Original Research

Accepted on 30 Jan 2026

Perspectives on Variability of In Vivo Toxicology Studies: Considerations for Next-generation Toxicology

in Regulatory Toxicology

Agnes L Karmaus
Anna L Kreutz
Oluwakemi Oyetade
Katie Paul Friedman
Martin Paparella
Emily N Reinke
David Allen
Helena Therese Hogberg
Nicole C Kleinstreuer

Frontiers in Toxicology

193 views

Original Research

Accepted on 29 Jan 2026

Effect of the cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on in vivo platelet activation, oxidative stress, and procoagulant responses induced by waterpipe smoke exposure in mice

in In Vitro Toxicology

Sumaya Beegam
Nur Elena Zaaba
Ozaz Elzaki
Javed Yasin
Badreldin H. Ali
Abderrahim Nemmar

Frontiers in Toxicology

140 views

Perspective

Published on 29 Jan 2026

Addressing animal methods bias through government-led initiatives

in In Vitro Toxicology

Jessica S. Kopew
Merel Ritskes-Hoitinga
Mikalah Singer
Emily R. Trunnell
Gabby Vidaurre
Catharine E. Krebs

Frontiers in Toxicology

doi 10.3389/ftox.2026.1761759

994 views

Original Research

Accepted on 27 Jan 2026

A Comparison of Honeybee and Scorpion Venoms as Anticancer Agents Against three different cancer cell lines: Lung, Colon, and Breast Cancer

in Clinical Toxicology

Fatma Galal
Fahad M Alshammari
Abdulrahman S. Aldaghmi
Elsayed E. Hafez
Ghada El-sayed
Riyadh H Aeban
Saad A Alharb

Frontiers in Toxicology

188 views

Original Research

Accepted on 27 Jan 2026

Appearance-Based Computer Vision Pipeline for Multi-Animal Monitoring of Canine Activity, Behavior and Clinical Observations

in Computational Toxicology and Informatics

Eline Eberhardt
Jef Plochaet
Tanguy Ophoff
Floris De Feyter
Sarah De Landtsheer
Greet B.A. Teuns
Maarten Vergauwen
Bianca Feyen
Toon Goedemé
Ivan Kopljar

Frontiers in Toxicology

162 views

Review

Accepted on 26 Jan 2026

Impact of PFAS exposure on lipid metabolic pathways: Mechanisms and implications in carcinogenesis

in Clinical Toxicology

Emily Ferguson
Josiane Weber Tessmann
Yekaterina Y Zaytseva

Frontiers in Toxicology

245 views

Review

Accepted on 26 Jan 2026

Predicted No Effect Concentrations (PNECs) of antifungals for wastewater management and agricultural use

in Environmental Toxicology

D. Gil
S. José
A. Ascenso
Monika Novak Babič
Esther Segal
Joseph Meletiadis
J. P. Gangneux
C. J. Weiskerger
Helena Solo-Gabriele
Elisabete Valério

Frontiers in Toxicology

145 views

Original Research

Accepted on 22 Jan 2026

Use of Gastroscopy in the Management of Pediatric Toxic Ingestions: Insights from a Decade of Experience – A Retrospective Study

in Clinical Toxicology

Marco Marano
Lavinia Di Meglio
Mara Pisani
Bianca Maria Goffredo
Carla Olita
Simona Faraci
Francesca Rea
Salvatore Perdichizzi
Giorgio Zampini
Piero David

Frontiers in Toxicology

135 views

Original Research

Published on 22 Jan 2026

Nicotine-free electronic vape fluid stimulates angiogenic processes in vitro through ARF6-mediated oxidative stress

in In Vitro Toxicology

Lewis Spurrier-Best
David Butcher
Evangelene Blackham-Hayward
Zsuzsanna Kertesz
Havovi Chichger

Frontiers in Toxicology

doi 10.3389/ftox.2025.1699112

1,046 views

Original Research

Accepted on 19 Jan 2026

Role of the protease-activated receptor 2 in multi-walled carbon nanotube-induced macrophage polarization ex vivo and airway fibrosis in murine allergic lung disease in vivo

in Nanotoxicology

Logan Tisch
Ryan D. Bartone
Silvio Antoniak
James C. Bonner

Frontiers in Toxicology

128 views

Original Research

Published on 16 Jan 2026

The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats

in Neurotoxicology

Hanan Mubarak Almutairi
Ahmad Hamad Alhowail

Frontiers in Toxicology

doi 10.3389/ftox.2026.1752511

756 views

Original Research

Published on 15 Jan 2026

Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats

in Developmental and Reproductive Toxicology

Samuel Abiodun Kehinde
Tolulope Peter Fatokun
Sarva Mangala Praveena
Abosede Temitope Olajide
Chau Ling Tham
Mariana Teles Pereira
Sasitorn Chusri

Frontiers in Toxicology

doi 10.3389/ftox.2026.1699288

830 views

Perspective

Published on 15 Jan 2026

A user-informed perspective of the toxicological data gap in India’s cannabis landscape

in Regulatory Toxicology

Muzafar Riyaz

Frontiers in Toxicology

doi 10.3389/ftox.2025.1734313

595 views

638 articles

articles

Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells

Ecotoxicological Thresholds of Glyphosate: Linking Sub-Lethal Exposure to Liver Tissue Damage and Behavioural Disturbances in African Catfish

Protective Effects of Lagerstroemia speciosa Against Paracetamol-Induced Renal and Testicular Toxicity in Rats via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round

Exploring Ethical, Sustainable and Effective Foetal Bovine Serum Alternatives for In Vitro Mammalian Cell Culture

Microplastic toxicity: mechanisms, assessment methods, and future research directions

A case report of arsenic-induced peripheral neuropathy misdiagnosed as Guillain-Barré syndrome

Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation

Multi-task deep learning models for mechanism-based prediction of developmental and reproductive toxicity (DART) using ToxCast bioassays

Clinical features of toxic encephalopathy induced by 1,2-dichloroethane

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption – a PARC project

Perspectives on Variability of In Vivo Toxicology Studies: Considerations for Next-generation Toxicology

Effect of the cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on in vivo platelet activation, oxidative stress, and procoagulant responses induced by waterpipe smoke exposure in mice

Addressing animal methods bias through government-led initiatives

A Comparison of Honeybee and Scorpion Venoms as Anticancer Agents Against three different cancer cell lines: Lung, Colon, and Breast Cancer

Appearance-Based Computer Vision Pipeline for Multi-Animal Monitoring of Canine Activity, Behavior and Clinical Observations

Impact of PFAS exposure on lipid metabolic pathways: Mechanisms and implications in carcinogenesis

Predicted No Effect Concentrations (PNECs) of antifungals for wastewater management and agricultural use

Use of Gastroscopy in the Management of Pediatric Toxic Ingestions: Insights from a Decade of Experience – A Retrospective Study

Nicotine-free electronic vape fluid stimulates angiogenic processes in vitro through ARF6-mediated oxidative stress

Role of the protease-activated receptor 2 in multi-walled carbon nanotube-induced macrophage polarization ex vivo and airway fibrosis in murine allergic lung disease in vivo

The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats

Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats

A user-informed perspective of the toxicological data gap in India’s cannabis landscape