Frontiers in Toxicology

Original Research

Published on 26 Apr 2024

Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use

in Immunotoxicology

Stella Cochrane
Ramya Rajagopal
David Sheffield
Fay Stewart
Lindsay Hathaway
Nicholas M. Barnes
Omar Qureshi
John Gordon

Frontiers in Toxicology

doi 10.3389/ftox.2024.1335110

3,189 views
2 citations

Review

Published on 22 Apr 2024

Abusive use of anabolic androgenic steroids, male sexual dysfunction and infertility: an updated review

in Developmental and Reproductive Toxicology

Rafael de Almeida Azevedo
Bruno Gualano
Thiago Afonso Teixeira
Bruno C. G. Nascimento
Jorge Hallak

Frontiers in Toxicology

doi 10.3389/ftox.2024.1379272

13,667 views
15 citations

Original Research

Published on 19 Apr 2024

Assessing susceptibility for polycyclic aromatic hydrocarbon toxicity in an in vitro 3D respiratory model for asthma

in Developmental and Reproductive Toxicology

Reese M. Valdez
Brianna N. Rivera
Yvonne Chang
Jamie M. Pennington
Kay A. Fischer
Christiane V. Löhr
Susan C. Tilton

Frontiers in Toxicology

doi 10.3389/ftox.2024.1287863

3,224 views
4 citations

Original Research

Published on 17 Apr 2024

The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop

in Immunotoxicology

Scott A. Fisher
Kimberley Patrick
Tracy Hoang
Elly Marcq
Kiarash Behrouzfar
Sylvia Young
Timothy J. Miller
Bruce W. S. Robinson
Raphael Bueno
Anna K. Nowak

Frontiers in Toxicology

doi 10.3389/ftox.2024.1373003

4,601 views
4 citations

Original Research

Published on 17 Apr 2024

Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

in Computational Toxicology and Informatics

Mark D. Nelms
Todor Antonijevic
Caroline Ring
Danni L. Harris
Ronnie Joe Bever
Scott G. Lynn
David Williams
Grace Chappell
Rebecca Boyles
Susan Borghoff

Frontiers in Toxicology

doi 10.3389/ftox.2024.1346767

2,504 views
3 citations

Original Research

Published on 11 Apr 2024

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

in Regulatory Toxicology

Todd Bourcier
Timothy McGovern
Tania Cavaliero
Geoffrey Ebere
Akiyoshi Nishikawa
Jihei Nishimura
Kumiko Ogawa
Markku Pasanen
Alisa Vespa
Jan Willem Van der Laan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1353783

7,880 views
9 citations

Original Research

Published on 11 Apr 2024

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

in In Vitro Toxicology

Marjory Moreau
Liam Simms
Melvin E. Andersen
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Fiona Chapman
Karin Roewer
Sandra Otte
Jeffrey Fisher

Frontiers in Toxicology

doi 10.3389/ftox.2024.1373325

5,235 views
14 citations

Review

Published on 09 Apr 2024

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

in Immunotoxicology

Igor Snapkow
Nicola M. Smith
Emma Arnesdotter
Karsten Beekmann
Etienne B. Blanc
Albert Braeuning
Emanuela Corsini
Marija Sollner Dolenc
Loes P. M. Duivenvoorde
Gunnar Sundstøl Eriksen

Frontiers in Toxicology

doi 10.3389/ftox.2024.1339104

8,493 views
13 citations

Policy and Practice Reviews

Published on 05 Apr 2024

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

in Regulatory Toxicology

Arianna Bassan
Ronald Steigerwalt
Douglas Keller
Lisa Beilke
Paul M. Bradley
Frank Bringezu
William J. Brock
Leigh Ann Burns-Naas
Jon Chambers
Kevin Cross

Frontiers in Toxicology

doi 10.3389/ftox.2024.1370045

5,904 views
7 citations

Perspective

Published on 28 Mar 2024

Digitalization of toxicology: improving preclinical to clinical translation

in Computational Toxicology and Informatics

Brian R. Berridge
Szczepan W. Baran
Vivek Kumar
Natalie Bratcher-Petersen
Michael Ellis
Chang-Ning Liu
Timothy L. Robertson

Frontiers in Toxicology

doi 10.3389/ftox.2024.1377542

5,264 views
5 citations

Original Research

Published on 26 Mar 2024

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity

in Regulatory Toxicology

Johanna Zilliacus
Monica K. Draskau
Hanna K. L. Johansson
Terje Svingen
Anna Beronius

Frontiers in Toxicology

doi 10.3389/ftox.2024.1357717

3,810 views
12 citations

Review

Published on 25 Mar 2024

Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

in Regulatory Toxicology

Brian Berridge
Jennifer Pierson
Syril Pettit
Norman Stockbridge

Frontiers in Toxicology

doi 10.3389/ftox.2024.1352783

3,196 views
3 citations

Correction

Published on 25 Mar 2024

Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

in In Vitro Toxicology

Albert Braeuning
Patrick Balaguer
William Bourguet
Jordi Carreras-Puigvert
Katreece Feiertag
Jorke H. Kamstra
Dries Knapen
Dajana Lichtenstein
Philip Marx-Stoelting
Jonne Rietdijk

Frontiers in Toxicology

doi 10.3389/ftox.2024.1394396

1,861 views

Original Research

Published on 21 Mar 2024

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling

in Computational Toxicology and Informatics

Arthur de Carvalho e Silva
George D. Loizou
Kevin McNally
Olivia Osborne
Claire Potter
David Gott
John K. Colbourne
Mark R. Viant

Frontiers in Toxicology

doi 10.3389/ftox.2024.1368320

4,413 views
4 citations

Original Research

Published on 18 Mar 2024

Green synthesis of silver and iron nano composites using aqueous extract of zanthoxylum armatum seeds and their application for removal of acid black 234 dye

in Nanotoxicology

Nadia Bashir
Saba Gulzar
Salma Shad

Frontiers in Toxicology

doi 10.3389/ftox.2024.1288783

3,317 views
2 citations

Editorial

Published on 15 Mar 2024

Editorial: Human biomonitoring (HBM) as a tool to support policy and regulatory action to prevent chemicals exposure

in Regulatory Toxicology

Susana Viegas
Carla Martins
Ricardo Assunção

Frontiers in Toxicology

doi 10.3389/ftox.2024.1376890

1,498 views
2 citations

Original Research

Published on 14 Mar 2024

Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells

in Immunotoxicology

Aafke W. F. Janssen
Wendy Jansen Holleboom
Deborah Rijkers
Jochem Louisse
Sjoerdtje A. Hoekstra
Sanne Schild
Misha F. Vrolijk
Ron L. A. P. Hoogenboom
Karsten Beekmann

Frontiers in Toxicology

doi 10.3389/ftox.2024.1347965

4,364 views
10 citations

Original Research

Published on 12 Mar 2024

Evaluation of the applicability of GARDskin to predict skin sensitizers in extracts from medical device materials

in In Vitro Toxicology

Rose-Marie Jenvert
Olivia Larne
Angelica Johansson
Mattias Berglin
Emma Pedersen
Henrik Johansson

Frontiers in Toxicology

doi 10.3389/ftox.2024.1320367

4,087 views
3 citations

Original Research

Published on 11 Mar 2024

Optimizing androgen receptor prioritization using high-throughput assay-based activity models

in Computational Toxicology and Informatics

Ronnie Joe Bever
Stephen W. Edwards
Todor Antonijevic
Mark D. Nelms
Caroline Ring
Danni Harris
Scott G. Lynn
David Williams
Grace Chappell
Rebecca Boyles

Frontiers in Toxicology

doi 10.3389/ftox.2024.1347364

2,540 views
4 citations

Original Research

Published on 08 Mar 2024

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

in Regulatory Toxicology

Thomas Jaylet
Thibaut Coustillet
Nicola M. Smith
Barbara Viviani
Birgitte Lindeman
Lucia Vergauwen
Oddvar Myhre
Nurettin Yarar
Johanna M. Gostner
Pablo Monfort-Lanzas

Frontiers in Toxicology

doi 10.3389/ftox.2024.1285768

10,585 views
16 citations

Original Research

Published on 06 Mar 2024

In vitro and in vivo studies on the effect of a mitochondrial fusion promoter on Leydig cell integrity and function

in Developmental and Reproductive Toxicology

Samuel Garza
Chantal Sottas
Hovhannes J. Gukasyan
Vassilios Papadopoulos

Frontiers in Toxicology

doi 10.3389/ftox.2024.1357857

3,482 views
3 citations

Original Research

Published on 28 Feb 2024

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

in In Vitro Toxicology

Zhengxi Wei
Tuan Xu
Judy Strickland
Li Zhang
Yuhong Fang
Dingyin Tao
Anton Simeonov
Ruili Huang
Nicole C. Kleinstreuer
Menghang Xia

Frontiers in Toxicology

doi 10.3389/ftox.2024.1321857

4,637 views
5 citations

Review

Published on 27 Feb 2024

Southeast Asia’s environmental challenges: emergence of new contaminants and advancements in testing methods

in Environmental Toxicology

Jacky Bhagat
Nisha Singh
Yasuhito Shimada

Frontiers in Toxicology

doi 10.3389/ftox.2024.1322386

12,146 views
18 citations

Original Research

Published on 23 Feb 2024

Assessment of ecotoxicological effects of Fojo coal mine waste elutriate in aquatic species (Douro Coalfield, North Portugal)

in Environmental Toxicology

Aracelis Narayan
Bárbara S. Diogo
Catarina Mansilha
Jorge Espinha Marques
Deolinda Flores
Sara C. Antunes

Frontiers in Toxicology

doi 10.3389/ftox.2024.1334169

2,354 views
4 citations

639 articles

articles

Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use

Abusive use of anabolic androgenic steroids, male sexual dysfunction and infertility: an updated review

Assessing susceptibility for polycyclic aromatic hydrocarbon toxicity in an in vitro 3D respiratory model for asthma

The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop

Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

Digitalization of toxicology: improving preclinical to clinical translation

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity

Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling

Green synthesis of silver and iron nano composites using aqueous extract of zanthoxylum armatum seeds and their application for removal of acid black 234 dye

Editorial: Human biomonitoring (HBM) as a tool to support policy and regulatory action to prevent chemicals exposure

Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells

Evaluation of the applicability of GARDskin to predict skin sensitizers in extracts from medical device materials

Optimizing androgen receptor prioritization using high-throughput assay-based activity models

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

In vitro and in vivo studies on the effect of a mitochondrial fusion promoter on Leydig cell integrity and function

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

Southeast Asia’s environmental challenges: emergence of new contaminants and advancements in testing methods

Assessment of ecotoxicological effects of Fojo coal mine waste elutriate in aquatic species (Douro Coalfield, North Portugal)