Upping the Heat: Capsaicin for Human Health

Capsaicinoids, secondary metabolites found in hot peppers (Capsicum spp.), are responsible for the characteristic pungency of these fruits. Traditionally, they have been utilized for food flavoring, preservation, and as remedies for ailments such as colds and rheumatism. Recent studies have highlighted capsaicin, the primary active component, for its potential health benefits, including enhanced thermogenesis, fat oxidation, and energy expenditure, which collectively contribute to reduced adiposity. Additionally, capsaicin has been shown to improve saliva flow and intestinal peristalsis, aiding digestion. Its anti-inflammatory and antioxidant properties suggest potential benefits for heart health, and it is a key ingredient in cutaneous pain relief treatments. Despite these promising findings, the use of capsaicin is not without risks, as excessive consumption can lead to adverse effects such as vomiting, nausea, diarrhea, and acid reflux. This underscores the need for a comprehensive discussion on the benefits and risks associated with capsaicinoid use in humans.

This research topic aims to explore the multifaceted roles of capsaicin and capsaicinoids in human health, with a particular focus on their potential benefits and associated risks. The primary objectives include investigating the pharmacological and physiological effects of capsaicinoids, understanding their mechanisms of action, and evaluating their therapeutic potential in various health conditions.

To gather further insights into the complex interactions between capsaicinoids and human health, we welcome articles addressing, but not limited to, the following themes:

- The role of capsaicinoids in heart health and cardiovascular disease prevention

- Mechanisms of capsaicin-induced thermogenesis and fat oxidation

- Capsaicin's effects on digestion and gastrointestinal health

- The use of capsaicin in pain relief and its underlying mechanisms

- Potential anti-cancer properties of capsaicinoids

- Capsaicinoids in the management of diabetes

- Quantification and extraction methods of capsaicinoids in different Capsicum spp.

- Clinical trials and case studies on capsaicin use in various health conditions

- Safety profiles and risk assessment of capsaicinoid consumption

This call for papers invites contributions from basic research, clinical research, reviews, and case studies to provide a comprehensive understanding of this significant topic.

Keywords: Food, Seasoning, TRPV1, Cancer, Inflammation, Pain, <i>Capsicum</i> spp., Capsaicinoids, Hot Pepper

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.