Inflammation constitutes an intricate biological response essential to the body's defense mechanisms, and chronic inflammation is implicated in a variety of diseases, underscoring the imperative for effective interventions. Plant-derived bioactive compounds, such as polyphenols in green tea and curcumin in turmeric, have shown their potential anti-inflammatory properties as nutritional supplements. Nonetheless, there is a limited understanding of the mechanisms of action and efficacy of these compounds in a variety of inflammatory conditions, and translating these promising effects to humans can be challenging. Moreover, it is crucial to consider the influence of processing methods on the nutritional value of plant-derived foods. Various stages of food processing, such as drying, milling, and extraction, as well as potential synergistic or antagonistic interactions between different compounds during processing, can affect the concentration and bioavailability of these bioactive compounds, providing valuable insights to explore the anti-inflammatory properties of these nutritional supplements.
This research topic aims to elucidate the potential of plant-derived bioactive compounds as nutritional supplements for the alleviation of chronic inflammation by exploring precise molecular pathways, evaluating in vivo outcomes, and embracing a multidisciplinary approach, to provide insights into evidence-based dietary recommendations for natural anti-inflammatory solutions. The impact of processing methods on the effectiveness of anti-inflammatory properties will also be explored.
We invite researchers to contribute original research articles, reviews, and methodological papers addressing the following themes:
● Investigate and elucidate the specific molecular pathways through which plant-derived bioactive compounds exert anti-inflammatory effects, focusing on signal transduction, gene expression, and immunomodulation.
● Evaluate the clinical efficacy of plant-derived bioactive compounds in managing inflammation through human studies. Assess outcomes such as changes in inflammatory biomarkers, symptom relief, and disease progression.
● Examine the bioavailability, absorption, and metabolism of key plant-derived bioactive compounds, emphasizing how these factors influence anti-inflammatory responses in the human body.
● Assess the impact of various food processing stages (drying, milling, extraction) on the concentration and bioavailability of plant-derived bioactive compounds. Investigate how processing methods can influence the anti-inflammatory potential.
● Investigate potential synergies or conflicts between different plant-derived bioactive compounds during processing. Explore methods to enhance the overall anti-inflammatory properties through processing strategies.
Keywords: plant-derived bioactive compounds, natural products, health-promoting, inflammation, nutritional intervention
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
