New Theories, Strategies, and Technologies for Designing Original Medicinal Molecules

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ORIGINAL RESEARCH

Published on 09 Jun 2025

Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

Xinxin Ying
Yangyong Lou
Yueming Wu
Weiwei Hu

doi 10.3389/fchem.2025.1622511

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ORIGINAL RESEARCH

Published on 22 Apr 2025

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

Jinchao Zhu
Qingyuan Lin
Honglin Zhu
Siqi Xie
Shengdong Nie

doi 10.3389/fchem.2025.1584588

2,148 views

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Frontiers in Chemistry

Medicinal and Pharmaceutical Chemistry

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