New Approach Methodologies in Regulatory Toxicology

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ORIGINAL RESEARCH

Published on 05 Nov 2025

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

R. R. Sillito
J. Sutherland
A. Milne
C. Giuliano
C. Sigfridsson
M. Rolf
A. K. Cherian
M. McClafferty
E. I. Rossman
2 more
A. M. Holmes

doi 10.3389/ftox.2025.1655330

689 views

ORIGINAL RESEARCH

Published on 08 Oct 2025

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

Jessica Ryman
Richard A. Becker

doi 10.3389/ftox.2025.1657708

1,257 views

ORIGINAL RESEARCH

Published on 15 Sep 2025

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

doi 10.3389/ftox.2025.1657189

1,098 views

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Frontiers in Toxicology

Regulatory Toxicology

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