New Approach Methodologies in Regulatory Toxicology

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ORIGINAL RESEARCH

Accepted on 08 Aug 2025

Reproduction of the Human Relevant Potency Threshold (HRPT) for Estrogen Receptor Alpha Agonism in an Inference Performance Screen for ICCVAM's Regulatory Scientific Confidence Framework

Jessica Ryman Ph.D., D.A.B.T.
Richard Becker

doi 10.3389/ftox.2025.1657708

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ORIGINAL RESEARCH

Accepted on 07 Aug 2025

Error-Corrected Next Generation Sequencing Mutagenicity Assays in Human HepaRG™ Cells as Human-Relevant Genetic Toxicology New Approach Methodology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

doi 10.3389/ftox.2025.1657189

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Frontiers in Toxicology

Frontiers in Toxicology

Regulatory Toxicology

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