Nanozymes are a class of nanomaterials harboring enzymatic properties that are capable of catalyzing enzyme substrates under physiological or extreme conditions, have enzymatic reaction kinetics similar to natural enzymes, and can serve human health as enzyme substitutes. Nanozymes are an example of multidisciplinary cross-fertilization, which is nowadays an emerging cutting-edge direction, advanced by scientists engaged in multiple fields such as chemistry, enzymology, materials, biology, medicine, and theoretical computing. Nanozymology aims to utilize multidisciplinary technology to reveal the new biomimetic catalytic properties of nanozymatic materials from the perspective of enzymology, analyze the enzyme-like catalytic mechanism of nanozymes, and develop high-efficiency nanozymes, so as to realize active regulation of related biochemical reactions and life activities at the levels of molecules, cells, tissues, and organisms, and then to develop diagnostic and therapeutic strategies for diseases.
Nanozymes have established a new paradigm for nanobiology research, which makes it easier to understand the catalytic behavior of nanomaterials in biological systems, and is conducive to the promotion of biomedically relevant applications of nanomaterials. The aim of this research topic is to introduce the cutting-edge development of nanozymes with potential translational value, to provide first-hand data for the development of the field, and to provide a good reference for the clinical application of nanozymes. This proceeding also encourages scientists to rationally design and develop novel nanozymes for precise diagnosis and treatment of diseases and to explore the structure and activity relationships of nanozymes.
In this Research Topic, we focus on highlighting the latest developments of nanozymes and their applications in diverse fields. We welcome the submissions of high-quality Original Research, Review, Mini-Review, and Perspective articles on this topic. Research themes include, but are not limited to the following:
• Rational design of nanozymes (design and synthesis of nanozymes with high activity and high selectivity based on theoretical calculations, catalytic constitutive relationships, biomimetic strategies, artificial intelligence, and high-throughput screening)
• Regulation of enzymatic activity of nanozymes and development of catalytic therapeutic strategies
• Applications of nanozymes in diverse fields such as antitumor, antibacterial, antiviral, anti-inflammatory, anti-Alzheimer's disease, anti-infarction, sewage treatment, sensors, probes, imaging, etc.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
- Editorial
- FAIR² Data
- FAIR² DATA Direct Submission
- Mini Review
- Original Research
- Perspective
- Review
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Keywords: Nanozymes, Diagnostic, Therapeutic, Enzymatic activity, Environmental governance
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
