Interplay Between Nutrition, Bacterial Extracellular Vesicles, and Immune Regulation

Microbial-derived vesicles, known as extracellular vesicles (EVs), have become pivotal in understanding the intricate relationships between microorganisms, nutrition, and host systems. These vesicles, produced by organisms such as bacteria and fungi, play critical roles by delivering bioactive molecules that influence nutritional status and host health. Of particular interest is the mechanistic understanding of how these vesicles interact with host cells, bridge the communication between gut microbiota and host, and influence nutritional uptake and immune modulation. The signalling pathways activated by microbial EVs and their recognition by host cells are crucial in deciphering their positive or negative health effects.

This Research Topic aims to investigate the variability in the composition of microbial EVs and its influence on their functionality, particularly concerning nutrition and dietary interactions. The lipid, protein, and nucleic acid profiles of EVs are subject to change based on environmental factors and nutrient availability, thereby affecting their nutritional properties and functionality. Understanding this variability is vital in harnessing the potential of EVs to enhance nutritional applications and develop functional foods.

To delve deeper into these phenomena, metabolomic studies offer a comprehensive avenue by linking specific microbial-derived EVs to health outcomes within the context of nutrition. Such studies can provide insights into the metabolic pathways influenced by EVs, bridging the gap between diet, microbiota, and host metabolism. Metabolomics can elucidate the role of EVs in mediating these interactions, thus fostering advancements in nutritional science and therapeutic strategies.

To gather further insights into microbial-derived vesicles in nutrition, we welcome articles addressing, but not limited to, the following themes:

o Mechanistic understanding of EV-host nutritional interactions
o Functional implications of compositional variability in microbial EVs within dietary contexts
o Comprehensive metabolomic studies correlating EVs with nutritional and health outcomes

Authors may submit original research, reviews, or meta-analyses that explore these dimensions and advance the field's understanding.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Systematic Review

Keywords: beneficial bacteria, probiotics, interkingdom communication, nutrition, food components, host immune responses

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.