Reimagining Therapeutic Discovery: Structural Biology's Role in Combatting Infectious Diseases

This Research Topic envisions the future of structural biology in infectious disease therapeutic discovery. It explores the potential of cutting-edge methodologies and technologies, such as advanced molecular imaging and high-throughput structural analysis, to revolutionize the identification of novel therapeutic targets. The discussion includes using AI-driven tools and chemical biology approaches to design and engineer proteins and enzymes for targeted drug development. By focusing on infectious and emerging diseases, including malaria, trichomoniasis, schistosomiasis and onchocerciasis, the study outlines how structural tools could lead to groundbreaking discoveries and innovations in treating infectious diseases, fulfilling sustainable health and well-being goals.

The goals of this Research Topic are as follows:
1) Advance Structural Biology in Therapeutic Discovery
Promote the use of structural biology to revolutionize the identification of therapeutic targets for infectious diseases.
2) Leverage Cutting-Edge Technologies
Integrate advanced molecular imaging and high-throughput structural analysis to improve target discovery.
3) Implement AI and Chemical Biology Approaches
Utilize AI-driven tools and chemical biology to design and engineer proteins and enzymes for precision drug development.
4) Focus on Neglected and Emerging Diseases
Apply structural biology tools to address infectious diseases, notably neglected and emerging diseases such as malaria, trichomoniasis, schistosomiasis, and onchocerciasis.
5) Drive Innovation in Infectious Disease Treatment
Enable groundbreaking discoveries in infectious disease therapeutics using structural biology insights.
6) Support Global Health and Sustainability
Contribute to achieving sustainable health and well-being goals through innovative biomedical research.

We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Structure-based drug discovery for infectious diseases
• Structural vaccinology for infectious diseases
• Emerging tools for infectious disease therapeutics discovery
• Structure-based drug repurposing

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• Mini Review
• Original Research
• Perspective
• Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• Mini Review
• Original Research
• Perspective
• Review

Keywords: Infectious diseases, Drug repurposing, Therapeutic discovery, Structural Biology

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.