Interplay Between Nutrition, Genetics, and Liver Health: Mechanisms and Interventions

Emerging evidence highlights the complex interplay between diet, genetic background, and metabolic regulation in liver disease. Nutrigenomics and nutritional genomics have provided powerful tools to investigate how specific nutrients and dietary patterns influence gene expression, epigenetic modifications, and metabolic pathways in the liver. At the same time, genetic predisposition contributes to interindividual variability in the development and progression of liver disorders, including MASLD, nonalcoholic steatohepatitis (NASH), and fibrosis. Understanding this bidirectional relationship between nutrition and genetics is essential for identifying biomarkers, improving dietary recommendations, and developing preventive strategies aimed at maintaining hepatic health.

Liver diseases represent a growing global health burden, largely driven by metabolic dysfunction and lifestyle factors. While nutritional interventions have proven effective in improving hepatic outcomes, individual responses to diet are influenced by genetic and molecular factors that remain insufficiently understood. This Research Topic aims to integrate insights from nutrition science and genetics to elucidate the mechanisms linking dietary patterns, gene–nutrient interactions, and liver health. By advancing the field of precision nutrition, we seek to identify tailored dietary strategies for the prevention and management of metabolic-associated steatotic liver disease (MASLD) and related disorders. Contributions that explore how genetics modulate dietary effects on hepatic metabolism will provide novel perspectives for personalized therapeutic approaches.

This Research Topic welcomes contributions that address the intersection of nutrition, genetics, and liver health. We encourage original research, systematic reviews, mini-reviews, and perspectives exploring:

• Nutrigenomic and nutrigenetic mechanisms in liver metabolism and disease;
• Gene–diet interactions influencing hepatic fat accumulation and inflammation;
• Effects of dietary interventions (e.g., Mediterranean diet, ketogenic diets, micronutrients) on liver-related genetic pathways;
• Biomarkers and molecular signatures of dietary response;
• Translational and clinical studies applying precision nutrition in the prevention or treatment of liver disease.

We particularly welcome submissions integrating multi-omics approaches or focusing on diverse populations to advance personalized nutrition strategies for liver health.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Registered Report
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Nutrigenomics, Genomics, Metabolism, MASLD, Nutrition, Genetics, Inflammation, Oxidative, Lipids, Hepatology, Diet

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.