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Published on 11 Jul 2025

‘Molecular shield’ placed in the nose may soon treat common hay fever trigger

Researchers here developed a monoclonal antibody specific against mugwort pollen – an important allergen causing hay fever – in mice, which is highly effective in blocking symptoms of IgE immunoglobin-mediated allergy against this pollen. The monoclonal antibodies can be delivered inside the nose, rather than intravenously, acting almost like a ‘molecular shield’. The study is a proof-of-principle, which can be extended to other pollen species.

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