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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2018.00584

Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes

 Alexander Pöthig1*,  Sara Ahmed2,  Hanne C. Winther-Larsen2, Shengyang Guan1, Philipp J. Altmann1, Jürgen Kudermann1, Adriana M. Santoz Andresen2,  Tor Gjøen2 and  Ove Alexander Høgmoen Åstrand2
  • 1Technische Universität München, Germany
  • 2University of Oslo, Norway

The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains (B. subtilis (ATCC6633), S. aureus (ATCC6538), E. coli (UVI isolate), P. aeruginosa), one fungus (C. albicans) and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells.

Keywords: NHC (N-heterocyclic carbenes), Silver, Gold, antimicrobial, Cytotoxicity, Organometallic, Supramolecular, Cavitand

Received: 30 Sep 2018; Accepted: 08 Nov 2018.

Edited by:

Angela Casini, Cardiff University, United Kingdom

Reviewed by:

Zoe Pikramenou, University of Birmingham, United Kingdom
Stephane Bellemin-Laponnaz, Centre national de la recherche scientifique (CNRS), France  

Copyright: © 2018 Pöthig, Ahmed, Winther-Larsen, Guan, Altmann, Kudermann, Santoz Andresen, Gjøen and Høgmoen Åstrand. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Alexander Pöthig, Technische Universität München, Munich, Germany, alexander.poethig@tum.de