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Front. Phys., 10 February 2021 |

Isolation and Contact Tracing Can Tip the Scale to Containment of COVID-19 in Populations With Social Distancing

  • 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
  • 2BioISI—Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal

SARS-CoV-2 has established itself in all parts of the world, and many countries have implemented social distancing as a measure to prevent overburdening of health care systems. Here we evaluate whether and under which conditions containment of SARS-CoV-2 is possible by isolation and contact tracing in settings with various levels of social distancing. To this end we use a branching process model in which every person generates novel infections according to a probability distribution that is affected by the incubation period distribution, distribution of the latent period, and infectivity. The model distinguishes between household and non-household contacts. Social distancing may affect the numbers of the two types of contacts differently, for example while work and school contacts are reduced, household contacts may remain unchanged. The model allows for an explicit calculation of the basic and effective reproduction numbers, and of exponential growth rates and doubling times. Our findings indicate that if the proportion of asymptomatic infections in the model is larger than 30%, contact tracing and isolation cannot achieve containment for a basic reproduction number (0) of 2.5. Achieving containment by social distancing requires a reduction of numbers of non-household contacts by around 90%. If containment is not possible, at least a reduction of epidemic growth rate and an increase in doubling time may be possible. We show for various parameter combinations how growth rates can be reduced and doubling times increased by contact tracing. Depending on the realized level of contact reduction, tracing and isolation of only household contacts, or of household and non-household contacts are necessary to reduce the effective reproduction number to below 1. In a situation with social distancing, contact tracing can act synergistically to tip the scale toward containment. These measures can therefore be a tool for controlling COVID-19 epidemics as part of an exit strategy from lock-down measures or for preventing secondary waves of COVID-19.

1 Introduction

The novel coronavirus (SARS-CoV-2) has established itself in all parts of the world. There are still no registered vaccines and treatment options to COVID-19 disease remain mainly supportive. Control of virus transmission and associated disease thus depends on preventive measures such as social distancing combined with isolation of infected persons and those that have high likelihood of being infected, for instance because they have been traced as contacts of infected persons [1, 2]. It has become clear that additional measures are needed to control epidemic transmission, for example by using active tracing of contacts in combination with isolation of infected contacts. Also, such measures are important in the context of exit strategies, i.e. once social distancing measures are reduced or lifted, as has been suggested recently [3]. It is unclear how effective such combinations of interventions can be in populations with social distancing in place [4].

To what extent local containment or local slowing down of an epidemic by isolation and contact tracing is successful depends on the fraction of infections that remain asymptomatic or have mild disease, on the infectiousness before the onset of symptoms [5, 6], and on testing rates. It is known that occurrence of asymptomatic infections, a high proportion of transmission occurring before the onset of symptoms, a long delay between case finding and isolation, and high overall transmissibility all factor in negatively in the likelihood that an outbreak can be contained [711]. For SARS-CoV-2, evidence indicates that a high fraction of infected persons is infectious before they show symptoms (up to 50%), that a substantial fraction of infections may be asymptomatic or show only mild symptoms (up to 80%), and that the epidemic doubling time in the absence of interventions may be one week or even less [6, 1218]. On the other hand, it is also reported that with intensive contact tracing it could be possible to trace the majority (>80%) of secondary infections [11, 19].

Here we provide a model-based analysis of the impact of isolation and contact tracing in a setting with various levels of social distancing measures, using varying levels of the effectiveness and timeliness of contact tracing. It is important to consider the impact of each of these interventions in isolation but also in combination, as it is known that each intervention that reduces transmission is expected to increase the effectiveness of additional interventions in a synergistic manner [20]. The current analyses extend and complement our earlier study in which the focus was purely on the impact on delays in testing and tracing of contacts of infected individuals [11]. Here we report effective reproduction number, the (exponential) rate of increase, and the doubling time of the epidemic for scenarios with various combinations of interventions. Considering that the capacity of healthcare systems is limited, it is important to assess which interventions are most effective in slowing down the rate of increase of case numbers during an ongoing outbreak. As it is likely that, on the one hand, isolation and contact tracing will be more effective in close contact settings with well-defined contacts (household) than in the community (commuting, public spaces), while, on the other hand, the potential impact of household interventions on the epidemic could be smaller, we stratify the analyses by transmission setting (henceforth called household and non-household) [9].

2 Methods

2.1 Overview

We use a stochastic transmission model based on a model that has been developed earlier [9], and which has been adapted to describe the biological characteristics of SARS-CoV-2 [11]. The model describes an epidemic while the proportion of immunes is low as a branching process. The model does not take into account clustering of infections, small world network effects, or other density dependent effects. Starting from a small set of initially infected individuals, the model calculates the numbers of latently infected persons, infectious persons, and persons that are diagnosed and isolated in time steps of one day. Latent infection, infectivity during the infectious period, and daily contact rates are quantified using distributions taken from the literature (Table 1). We distinguish between household contacts (e.g. housemates, but also other persons with whom contact is regular and close like care takers), and non-household contacts with whom frequency and duration of contact is lower. The two types of contacts differ in the risk of infection, and the delay and effectiveness of tracing and isolation may be different. Intervention effectiveness is determined by the daily probability of being diagnosed during the infectious period (Table 2). Furthermore, intervention effectiveness depends on the delays in tracing household and non-household contacts, respectively, and the proportions of contacts can be found and isolated or quarantined. Here isolation applies to stopping contacts of a person who is diagnosed with COVID-19, while quarantine means that a person who is not yet tested refrains from contacts. We assume that isolation and quarantine are perfect, i.e. that isolated and quarantined persons cannot transmit any longer. See Figure 1 for a schematic description of the transmission and contact tracing process. The model is described by a set of difference equations, and allows for explicit computation of the basic reproduction number 0 and the effective reproduction number under interventions e. Although the model is a dynamic stochastic model, here we only report results on expectations of effective reproduction numbers, exponential growth rates and doubling times. For more information about the time dependent version of the model and some results concerning the exponential growth phase of the COVID-19 epidemic, we refer the reader to [9, 21]. The model is coded in Mathematica 12.1 and is available in our GitHub repository. We give a summary of the model assumptions here, and provide a technical description in the Supplementary Appendix.


TABLE 1. Disease and transmission parameters.


TABLE 2. Parameters related to diagnosis and contact tracing.


FIGURE 1. Schematic description of the transmission and contact tracing process.

2.2 Natural History of Infection

We assume that the latent period lasts between 1 and 3 days with a given probability per day of moving to the infectious state. Individuals then become infectious for at most 10 days [22]. Infectivity is high at the beginning of the infectious period and decays to low levels during these 10 days (Figure 2A). The probability of symptom onset increases during the first 3 days of the infectious period, thereby influencing the daily probability of diagnosis during the infectious period (see Section 2.4 and Figure 2B). Incubation period distribution and infectivity were fitted to recent estimates by Li et al [15], He et al [23], and Ashcroft et al [24]. The average incubation period in our model was 5.2 days with standard deviation of 3.9 days. An infectious individual makes contacts with household members and persons outside the household. We model the daily number of household contacts with a Poisson distribution, and the numbers of non-household contacts with a negative binomial distribution (Table 1), with parameters based on the average household size in the The Netherlands, and numbers of contacts observed in a contact study in the The Netherlands (Figure 2C) [25]. With the chosen parameters, the mean number of contacts per day is 13.2 with standard deviation of 8.5 days.


FIGURE 2. (A) The transmission probability per day of the infectious period; (B) the probability of developing symptoms per day since infection; (C) the probability distribution of the number of contacts per day; and (D) percent onward transmission per day since infection.

On each day of the infectious period, an individual makes a number of contacts according to the contact distribution. This number is reduced by a factor describing the probability that the contact person has already been infected during earlier contacts with the index person. Figure 2A shows the probability distribution of transmission upon contact with a susceptible household contact. As contacts with persons outside the household are often less close, and secondary attack rates in non-household contacts are observed to be lower than in household contacts [26], we assume that the transmission probability for these contacts is lower by factor 0.25. For this reduction factor, Figure 2D shows the percentage of onward transmissions per day since becoming infected, e.g. around 40% of transmission occurs in the first 4 days after acquisition of infection, i.e. before the average time of symptoms onset [24].

2.3 Social Distancing

Social distancing can be self-imposed, if people decide to reduce their social contacts during the outbreak, and it can be government-imposed by closing schools, workplaces, and other venues of social gatherings [27]. Here we assume that when social distancing is applied, household contacts remain unchanged, but the mean number of non-household contacts is reduced. This is implemented by a reduction factor in the mean of the negative binomial distribution describing non-household contact numbers. The reduction factor for social distancing was varied between 0 and 95%. In scenarios with social distancing we assumed that 80% of cases are symptomatic or can be ascertained [28]. In surveys during the lock-down in the first wave of SARS-CoV-2 in the The Netherlands, it was shown that the daily number of community contacts was reduced by 71% to around 3.7 per day [29] and after the partial lifting of the measures the number of contacts slowly increased again. Similar decreases in contact numbers during the lock-down in the United Kingdom were reported by [30].

2.4 Diagnosis, Contact Tracing, and Isolation

An infectious person becomes symptomatic with a given probability per day since infection (Figure 2B). For SARS-CoV-2 the probability of developing symptoms is high in the first few days of the infectious period and then declines. If an infected and infectious person has not developed symptoms 10 days after acquisition of the virus, the probability that he/she will still do so is very small. The probability of developing symptoms determines whether he/she will be diagnosed and isolated. The total probability of developing symptoms determines the fraction that remains asymptomatic or otherwise undiagnosed, i.e. if the total probability of developing symptoms is smaller than 1, a proportion of the infected persons will remain undiagnosed and can transmit throughout their infectious period. With the assumed distributions, on average at least half of all potential onward transmissions will have occurred before an infected person is diagnosed and isolated. If diagnosis is delayed, because a person does not get tested immediately at symptom onset, and then it takes time until a test result is available, this proportion will be higher. This delay, i.e. the time between symptom onset until a symptomatic person gets a positive diagnosis, is denoted here as the testing delay. A testing delay is implemented in the model by setting the diagnosis probability to zero for the number of days of delay, and shifting the probability of diagnosis distribution to the right.

If an individual is diagnosed, contacts will be traced. Traced infected persons will be diagnosed and isolated. Tracing goes back in time for a given number of days to trace all contacts of the index case during this time window. There may be a delay before contacts are found and diagnosed, and only a fraction of all contacts may be found. These parameters, tracing delay and tracing coverage, may be different for household and non-household contacts. We assume that all traced infected persons are immediately isolated and cannot transmit any further. In reality, there might be a delay between tracing a contact and its effective isolation, but we interpret the tracing as an ‘effective tracing delay’ that encompasses the time from positive diagnosis of the index case until isolation of the contact. Therefore, the only individuals who will continue transmitting are those who are not found by tracing and are not yet diagnosed. Table 2 shows the parameter values related to diagnosis and contact tracing.

2.5 Baseline Scenario

For assessing the effectiveness of contact tracing and isolation, we use a best case scenario, where all parameters are set to optimistic values. We assume that when a case is diagnosed, he/she will immediately be isolated and this will stop onward transmission completely. Furthermore, we assume that all contacts will be traced, and if found infected will be isolated immediately. We assume that it takes 0 days to find and isolate both household and non-household contacts. The rationale for using these optimistic assumptions as a baseline is that it enables investigation of the maximum contribution contact tracing can provide for achieving containment. We then investigated for various control parameters at which point of diverging from the baseline parameters control of the outbreak will be lost. We also considered more realistic parameter combinations with imperfect contact tracing, in particular including delays and reduced tracing coverages (see also [11]).

2.6 Output Variables

The model allows an explicit calculation of the basic reproduction number 0 and effective reproduction number e [9, 11]. 0 is defined as the number of secondary cases an index case generates on average in a susceptible population without any intervention. e is the number of secondary infections per case when an intervention is in place. 0 is determined by daily transmission probabilities and numbers of contacts, and e in addition by the level of social distancing, diagnosis probabilities, tracing delays, and tracing coverage per day of the infectious period. We can therefore investigate how e depends on 0, and on the intervention parameters. Details are given in the Supplementary Appendix.

We are interested in the critical tracing coverage, i.e. what proportion of non-household contacts needs to be found and isolated to control the outbreak, for populations with various levels of social distancing. Furthermore, we study the epidemic growth rate (or epidemic doubling time) without and with contact tracing and isolation and various levels of social distancing. In sensitivity analyses, we study how these quantities depend on the testing delay of the index case and on the tracing delay in contact tracing. For example, we assume that household contacts can be traced with a high coverage without delay, but that tracing of non-household contact may take longer and be less complete.

Based on the distributions of the latent and infectious periods and infectivity, we calculate the exponential growth rates and doubling times under various assumptions on the intervention parameters. This gives additional information for situations where the outbreak is not controllable, because intervention measures will lower the growth rate and increase the epidemic doubling time.

We investigated how controllability of the outbreak depends on the fraction of infections that develop symptoms and therefore vary this percentage between 0 and 100%. We then considered combinations of interventions and their impact on the effective reproduction number, growth rate, and doubling time of the epidemic. We varied levels of social distancing, and coverage of tracing of household and non-household contacts. In our analysis for different levels of social distancing we assumed that 80% of infected persons develop symptoms [28, 31].

3 Results

3.1 Basic and Effective Reproduction Numbers

In the baseline scenario without interventions we calibrate the transmission probability such that 0=2.5. In this case, 39% of transmission events take place in the household. The basic reproduction number of household contacts is 0.97, and that of non-household contacts 1.53. Hence, if all non-household transmissions could be prevented, the outbreak would be just under the control limit. In the baseline scenario without interventions the exponential growth rate is 0.16 per day and the doubling time is 4.4 days, which agrees with published estimates [32, 33]. Figure 3 shows the relation between 0 and e for varying levels of the tracing coverage and testing delay. In Figure 3A, where testing delay is kept at 0 days, we find that for a tracing coverage of 40% and higher, e<1, i.e. the epidemic can be controlled by contact tracing and isolation. Similarly, if tracing coverage is 100%, as shown in Figure 3B testing delay can be at most 1 day to keep e<1. For lower values of 0, for example if reproduction numbers are reduced by social distancing, control is possible at longer delays and lower tracing coverages. However, this is only possible if all other parameters are at optimal values.


FIGURE 3. The effective reproduction number e for varying values of the basic reproduction number 0 in the optimistic baseline scenario, and for various values of the tracing coverage for non-household contacts (A) or testing delay (B). Tracing coverage of household contacts is assumed to be 100%.

3.2 Fraction of Non-household Contacts Needed to Be Traced and Isolated

The question arises how effective contact tracing has to be to keep the outbreak under control if there is a testing delay. We therefore compute the minimum fraction of non-household contacts that need to be traced and isolated (henceforth termed “critical tracing coverage”) to bring e below 1 (Figure 4). If 80% of infected persons develop symptoms [28, 31] and subsequently get tested, there is a chance of controlling the outbreak if the coverage of tracing non-household contacts is above the critical tracing fraction for a testing delay of at most a single day (Figure 4A). If 60% of infected persons develop symptoms and are tested even perfect contact tracing cannot control the outbreak. Further, in Figures 4C,D we vary the tracing delay of non-household contacts from 0 to 4 days, assuming no testing delays. If 80% of infection are symptomatic and diagnosed, the tracing delay should not be more than 2 days, while control is not possible if only 60% of infections are symptomatic and diagnosed.


FIGURE 4. The critical tracing coverage for varying values of the basic reproduction number 0;(A) 80% symptomatic and diagnosed index cases and varying testing delay, (B) 80% symptomatic and diagnosed index cases and varying tracing delay for both household and non-household contacts; (C) 60% symptomatic and diagnosed index cases and varying testing delay, (D) 60% symptomatic and diagnosed index cases and varying tracing delay for both household and non-household contacts.

3.3 Impact of Asymptomatic Cases

Not being diagnosed can be a consequence of not developing symptoms, having only mild symptoms, or any other reason why infected persons might not be identified by healthcare system. We subsume these possible reasons for cases not being ascertained under the term “asymptomatic”. With increasing proportion of asymptomatic cases, the possibility of controlling the outbreak with contact tracing and isolation quickly fades. This is illustrated in Figure 5, in which we plot the critical tracing coverage for non-household contacts for several values of 0 as a function of the fraction of symptomatic cases (i.e. the fraction of those who will eventually develop symptoms during their entire infectious period). Household contacts are assumed to be always traced and isolated. The figure shows that for 0=2.5 control is not possible with isolation and contact tracing, if less than 80% of all infected persons develop symptoms or are otherwise not detected by the healthcare system. This is true even if all other parameters are at their most optimistic values. Other control measures such as social distancing are then needed for containment.


FIGURE 5. The critical tracing coverage for varying percentages of symptomatic infections and values of the basic reproduction number 0 between 1.5 and 3.5. If the critical tracing coverage is above the line, the outbreak can be controlled. However, if the coverage reaches the blue line, control is lost. If more than 20% of cases escape diagnosis, because they are asymptomatic or have only mild symptoms, for 0=2.5 the outbreak is not controllable even with our optimistic baseline values for the intervention parameters.

3.4 Exponential Growth Rates and Doubling Times

If epidemic control is not possible with isolation and contact tracing only, it might still be possible to slow down the epidemic and thereby lower demand for the healthcare system. We find that contact tracing has a significant impact on the epidemic growth rate for short testing delays (Figure 6A) and high coverage of tracing non-household contacts (Figure 6C). Figures 6B,D show the associated epidemic doubling times (see the Supplementary Appendix for details). If 60% of cases are symptomatic and diagnosed, while contact tracing is efficient (i.e. short testing delay and high tracing coverage) the doubling time can be increased to about 15 days. If less than 60% of infections are symptomatic and ascertained, however, the impact of contact tracing on the doubling time is small.


FIGURE 6. The exponential growth rate and associated epidemic doubling time as a function of the testing delay (A and C) and coverage of contact tracing (B and D). The colors depict the fraction of infections that is symptomatic, and which is varied from 60% (pink) to 80% (blue). The outbreak is controlled when the exponential growth rate is smaller than zero (red horizontal line). If 60% of infections are symptomatic, contact tracing and isolation can slow down the epidemic to around 15 days, but they cannot control it, even if there is no diagnosis delay and all non-household contacts are traced.

3.5 Social Distancing and Contact Tracing

Social distancing in theory could reduce the effective reproduction number to below 1, but only if the number of non-household contacts is reduced to near zero. In practice this will be hard to achieve. Additional effort into tracing and isolation of household contacts are then needed to achieve containment. In Figure 7A we consider a scenario in which 80% of infected persons who develop symptoms are tested and isolated, and social distancing is implemented. The figure shows the critical tracing coverage as a function of the reduction of non-household contacts. In the brown area, it is sufficient to trace and isolate household contacts with a coverage above the critical coverage. In the purple area, also non-household contacts need to be traced with a coverage above the critical coverage in addition to tracing and isolating 100% of household contacts. We find that, if social contacts outside the household are reduced by at least 30%, isolating all household contacts is sufficient for control. If non-household contacts are reduced by more than 50%, testing and isolating of cases without tracing is sufficient to bring e below 1. Similarly, Figure 7B shows the critical tracing coverage if testing coverage is only 60%. Here, there is less testing and the tracing coverage needs to be higher, or, alternatively, there needs to be a larger reduction in non-household contacts. Note that all diagnosed cases must be isolated immediately and isolation needs to be perfect.


FIGURE 7. The critical tracing coverage in a population with social distancing and 0=2.5. In the brown shaded area tracing of household contacts is sufficient, in the purple area a certain level of non-household contacts have to be traced in addition to 100% of household contacts. (A) 80% testing coverage; (B) 60% testing coverage.

In Figure 8, we explore the impact of social distancing on the exponential growth rate and doubling time, again for the scenario with a testing coverage of 80%. The curves show how the exponential growth rate and doubling time are affected by the reduction of non-household contacts, for various coverage levels of tracing household and non-household contacts. Figure 8A shows how the exponential growth rate decreases with increasing level of social distancing, and also how increasing coverage of tracing household and non-household contacts lowers the exponential growth rate. Figure 8B shows the associated doubling times. We consider scenarios of with increasing coverage of contact tracing. First, only household contact are traced with coverage increasing from 0 to 100% in increments of 20% (green to yellow curves in Figure 7); then in addition to tracing 100% of household contacts, an increasing fraction varying from 0 to 100% in increments of 20% of non-household contacts are traced (blue to magenta curves in Figure 7). We find that in situations where control of the epidemic is not possible, i.e. when the reduction of non-household contacts remains lower than about 50%, an effective tracing may help to greatly increase epidemic doubling times.


FIGURE 8. The exponential growth rate (A) and epidemic doubling time (B) as a function of the level of social distancing and coverage of contact tracing. Testing coverage is set to 80%. The colors represent different coverage levels of contact tracing. For the lines colored from green to yellow only household contacts are traced and isolated; for the lines colored from blue to magenta, 100% of household contacts are traced and an additional fraction of non-household contacts are traced and isolated.

4 Discussion

Our analyses show that rapid diagnosis and isolation of infections based on COVID-19 disease alone cannot control outbreaks of SARS-CoV-2, but that the addition of tracing and isolation of traced cases could in theory be successful (Figure 3) [3, 11, 19, 3437]. In practice, however, the potential for containment will be seriously jeopardized by delays and imperfections in the tracing process. Especially delays in diagnosis and isolation, and the existence of asymptomatic and mild infections that contribute to onward transmission could make control difficult. As evidence is mounting that the proportion of asymptomatic and mild cases is large and leads to substantial numbers of unascertained cases, most countries have implemented strategies of social distancing or full lock-downs. Such measures have proven effective earlier during the 2009 influenza pandemic [38, 39]. However, social distancing can never be complete, as healthcare workers and doctors have to continue their work, but also personnel of supermarkets, public transport employees, and others will have contact outside their households. We find that in a situation where 60% of cases are ascertained, social distancing of non-household contacts fails to contain the epidemic even if contacts outside the household are reduced by 80%. In this case, combining the social distancing with tracing and isolation of household contacts may suffice to bring the balance toward containment. If social distancing is less severe, more intensive contact tracing and also tracing of non-household contacts is needed (Figure 7). If social distancing reduces non-household contacts only by 50%, tracing and isolation also of non-household contacts is needed for containment. If this is not possible, for example due to constraints of the public health system, tracing and isolation of household contacts can at least substantially increase the doubling time of the epidemic (Figure 8).

Even though the SARS-CoV-2 pandemic cannot be contained by contact tracing and rapid isolation alone, this does not render contact tracing useless. On the contrary, contact tracing and isolation when used in addition to social distancing, may be the tool needed to make this mix of strategies successful. Our analyses show that isolation and contact tracing when combined with social distancing can contribute to reducing the growth rate and increasing the doubling time of epidemics, thereby buying time, spreading the number of severe cases out over a longer period of time, and potentially also reducing the total number of infections [40]. This will lower peak healthcare demand, alleviate the stress on healthcare systems, and contribute to reducing the burden of disease.

Our analyses of contact tracing add to an earlier study by a more systematic analysis of the relation between key parameters (transmissibility, fraction asymptomatic, fraction of contacts traced, diagnosis delays), and by incorporating household vs. non-household contacts [34]. Household contacts are at a higher risk of becoming infected than non-household contacts as persons in a household will usually have repeated contacts. On the other hand, our analyses show that household infections contribute less to onward transmission than non-household infections simply because the numbers of household contacts are much lower than numbers of other contacts. As a consequence, the effectiveness of isolating non-household contacts is key for a successful contact tracing strategy. Our assumption that asymptomatic cases are as infectious as symptomatic cases may result in an overestimation of the contribution of asymptomatic cases to transmission. This might mean that effectiveness of contact tracing is more favourable than found in our analyses.

A strength of our model is that quantitative information about distributions of the latent and infectious periods, and the infectivity per day of the infectious period can be incorporated easily and detailed, such that if new and better data become available, the analyses can be updated quickly. In particular, the model can incorporate non-standard distributions based on empirical data (e.g. viral load measurements to quantify infectiousness per day).

A limitation of the analyses presented here is that they apply to a situation in which the epidemic is described by a branching process and is growing exponentially. This also applies to another modeling using a (one-type) branching process [34]. Ultimately, as the number of persons who are or have been infected increases, the number of persons that are still susceptible will start to dwindle, and epidemic growth will ultimately come to a halt. Hence, strictly speaking our results apply to the early stages of an epidemic. However, in the present situation, the proportion of the population who is immune for COVID-19 does in general not exceed 10% in most places [41]. In fact, even when the number of infected persons is still relatively small in the early stage of an epidemic it is possible that exponential growth is not observed, for instance due to local depletion of susceptible persons in combination with clustering in contact patterns, spatial effects, and inhomogeneous mixing [42]. However, estimates of the effective reproduction number are independent of the dynamics and give information about the ability of an intervention to slow down epidemic spread. Also, at present it is only in few places in the world where cumulative infection attack rates may have surpassed the 10% level.

In conclusion, our results show that in populations where social distancing is implemented, isolation and contact tracing can play an essential role in gaining control of the COVID-19 epidemic. On their own, none of these strategies are able to contain COVID-19 for realistic parameter settings, but in a combined strategy they can just tip the balance toward containment. These insights provide guidance for policy makers, who will have to decide when and how to release severe lock-down or social distancing measures, and whether additional contact tracing and isolation is then a feasible alternative to keep a resurging epidemic at bay.

Data Availability Statement

Publicly available datasets were analyzed in this study. This data can be found here:

Author Contributions

MK, MB, and GR conceived the study. MK designed and programmed the model, and produced output. All authors interpreted the results, contributed to writing the manuscript, and approved the final version for submission.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


We thank Martin Bootsma for help with the estimation procedure. MK acknowledges support from the Netherlands Organization for Health Research and Development (ZonMw; Grant no. 91216062 and Grant no. 10430022010001). GR acknowledges support from the Portuguese Foundation for Science and Technology (FCT; Grant no. 131_596787873).

Supplementary Material

The Supplementary Material for this article can be found online at:


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Keywords: contact tracing, branching process model, effective reproduction number, exponential growth rate, doubling time, social distancing

Citation: Kretzschmar ME, Rozhnova G and van Boven M (2021) Isolation and Contact Tracing Can Tip the Scale to Containment of COVID-19 in Populations With Social Distancing. Front. Phys. 8:622485. doi: 10.3389/fphy.2020.622485

Received: 28 October 2020; Accepted: 31 December 2020;
Published: 10 February 2021.

Edited by:

Sen Pei, Columbia University, United States

Reviewed by:

Hao Lei, Zhejiang University, China
Wei Wang, Sichuan University, China
Hongyu Miao, University of Texas Health Science Center at Houston, United States

Copyright © 2021 Kretzschmar, Rozhnova and van Boven. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Mirjam E. Kretzschmar,