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ORIGINAL RESEARCH article

Front. Plant Sci.
Sec. Plant Biotechnology
Volume 15 - 2024 | doi: 10.3389/fpls.2024.1403753

Phyto-synthesized Silver Nanoparticles from Sargassum subrepandum: Anticancer, antimicrobial, and molluscicidal activities

Provisionally accepted
Heba El-Sayed Heba El-Sayed 1Asmaa Abdelsalam Asmaa Abdelsalam 1Mostafa Y. Morad Mostafa Y. Morad 1Hana Sonbol Hana Sonbol 2*Amina M. Ibrahim Amina M. Ibrahim 3Eman Tawfik Eman Tawfik 1
  • 1 Faculty of Science, Helwan University, Cairo, Beni Suef, Egypt
  • 2 College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
  • 3 Theodor Bilharz Research Institute, Giza, Giza, Egypt

The final, formatted version of the article will be published soon.

    In the realm of nanotechnology, the use of algae to produce nanoparticles is an environmentally friendly, sustainable, and economically viable strategy. In the present study, the brown macroalgae Sargassum subrepandum was utilized to effectively produce silver nanoparticles (AgNPs). Through various characterization techniques, the AgNPs' structural integrity was confirmed. AgNPs exhibited significant antimicrobial activity against Pseudomonas aeruginosa and Fusarium equiseti.. AgNPs showed cytotoxic effects on the MCF-7 breast adenocarcinoma cell line with an IC50 of 12.5 µg/ml. Treatment with AgNPs resulted in a marked reduction in cell viability, alongside evident apoptotic and necrotic morphological changes in the cancer cells.. Through molecular docking studies, a deeper understanding of the interaction between AgNPs and crucial proteins related to cancer has been achieved,... AgNPs showed a promising molluscicidal action on Biomphalaria alexandrina snails, a Schistosoma mansoni intermediate host. The half-lethal dose (LC50) of AgNPs was determined to be 0.84 mg/L. The potential consequences of its administration include potential disruptions to the glycolysis profile, as well as potential impacts on the steroidal hormone’s estrogen and testosterone and certain kidney function tests. This study highlights the diverse uses of algae-synthesized AgNPs, ranging from healthcare to environmental management, demonstrating their importance in advancing nano-biotechnological solutions.

    Keywords: anticancer, Biomphlaria alexandrina, macroalagae, breast cancer, Sargassum subrepandum, In Silico Font: 16 pt, antimicrobial

    Received: 19 Mar 2024; Accepted: 18 Apr 2024.

    Copyright: © 2024 El-Sayed, Abdelsalam, Morad, Sonbol, Ibrahim and Tawfik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hana Sonbol, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.