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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychol. | doi: 10.3389/fpsyg.2019.01700

Structural and functional connectivity-based alternation between amygdala and orbital frontal cortex in burning mouth syndrome: an fMRI study

 Lingyu Kong1*, Ying Tang2,  Xunhua Wu3, Jing Chen4 and Zhaoxin Qian5
  • 1Department of Radiology, Xiangya Hospital, Central South University, China
  • 2Health Management Center, Xiangya Hospital, Central South University, China
  • 3Department of Radiology, Xiangya Hospital, Central South University, China
  • 4Department of Stomatology, Third Xiangya Hospital, Central South University, China
  • 5Department of Emergency, Xiangya Hospital, Central South University, China

With a burning sensation in the tongue or other oral sites in the absence of observable lesions or laboratory findings, burning mouth syndrome (BMS) is a chronic intraoral pain disorder. Previous stud have suggested the brain change in BMS, however, limited number of participants of these studies did not allow us to draw concrete conclusions. The present study aimed to further understanding the brain anatomical and functional changes of BMS with a relatively large sample. Fifty-three patients (26 BMS patients and 27 gender- and age-matched controls) were recruited. Participants came to complete the behavior interview, and performed the MRI scan in the same day. Results revealed that BMS patients had higher depression and anxiety than controls. BMS Patients showed lower GMV in bilateral VMPFC and increased functional connectivity with this region to bilateral amygdala. The brain measures could predict the years of symptom in the BMS group. These results may suggest the neuro-marker for diagnose and treatment of BMS.

Keywords: Burning mouth syndrome (BMS), Brain, functional connectivity, Amygdala, vmPFC

Received: 04 May 2019; Accepted: 08 Jul 2019.

Edited by:

Qinghua He, Southwest University, China

Reviewed by:

Feng Liu, Tianjin Medical University General Hospital, China
Zhengge Wang, Department of Radiology, Nanjing Drum Tower Hospital, China  

Copyright: © 2019 Kong, Tang, Wu, Chen and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Lingyu Kong, Xiangya Hospital, Central South University, Department of Radiology, Changsha, 410008, Hunan Province, China, 365411020@qq.com