The development of bioactive biomaterials is an important component in the general field of tissue engineering, specifically for the success of tissue repair and regeneration approaches (). Bioactive properties including antibacterial, antiinflammatory, antitumor and antioxidant activities can efficiently regulate cell attachment, proliferation, differentiation, and the immune microenvironment, which are essential cellular functions regulating new tissue formation (). Therefore, the science and technology of bioactive biomaterials continue to be at the center of the interest of researchers in the biomedical area worldwide.
Engineered bioactive materials involve conventional biomaterials, such as bioactive glasses and ceramics, as well as biopolymers based on proteins. Polysaccharides and biomoleculecontaining biomaterials (). In recent years, the development of nanomaterials has brought new possibilities for tissue regeneration, due their unique surface, small size, and quantum size effects (). Thus, nanoscale bioactive materials have attracted increasing interest in regenerative medicine recently (; ). For example, relative to conventional bioactive glass, bioactive nanoscale glasses (BNG) have shown enhanced apatite-forming ability and osteogenic differentiation activity, as well as improved bone regeneration capability (; ). Additionally, BNG also present controlled release of ions and tailorable degradation, as well as multifunctionalities, being thus interesting for a broad range of biomedical applications (). Up to now, BNG have demonstrated huge potential for applications in gene delivery, cancer therapy, antiinfection, immunoregulation, bioimaging, and soft tissue regeneration (; ; ; ; ). In addition to BNG, a great number of nanoscale biomaterials, both organic and inorganic nanoparticles, nanofibers and other nanostructures, are being considered for applications in tissue regeneration, usually combined with local drug and growth factor delivery.
This Research Topic is the second part on the “Multifunctional Bioactive Nanomaterials for Tissue Regeneration” series, which includes several papers demonstrating the main advances of multifunctional nanomaterials in tissue engineering. In this topic, Sprio et al. reviewed the application of biomorphic transformations to obtain nanostructured 3-D bioceramics. Yanmei Tang et al. reviewed the advances of polydopamine nanoparticles in tissue engineering applications, including the repair of bone, cartilage, skin, heart, and nerve. Fujian Zhao et al. reported tantalum-gelatin methacryloyl-bioactive glass (Ta-GelMA-BG) scaffolds which could enhance osteointegration at the early stage of implantation. Haiping Lu et al. developed Ag and MSCs-derived exosomes-contained PCL scaffold for regulating immune cells and MSCs proliferation and differentiation. Haiping Lu et al. introduced the broad application of β-TCP in tissue engineering and discussed different approaches to enhance and customize β-TCP scaffolds, including physical modification.
The editors hope that the current topic “Multifunctional Bioactive Nanomaterials for Tissue Regeneration Part 2” will contribute to inspire future developments of advanced bioactive nanomaterials for regenerative medicine to close the gap between research and clinical applications.
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We sincerely thank the support from all contributing authors and referes as well as responsible editors at the publisher.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Summary
Keywords
bioactive, multifunctional, nanomaterials, tissue engineering, cancer therapy
Citation
Lei B, Boccaccini AR and Chen X (2022) Editorial: Multifunctional Bioactive Nanomaterials for Tissue Regeneration, Volume 2. Front. Chem. 10:848369. doi: 10.3389/fchem.2022.848369
Received
04 January 2022
Accepted
06 January 2022
Published
25 January 2022
Volume
10 - 2022
Edited and reviewed by
Xiaomin Li, Fudan University, China
Updates
Copyright
© 2022 Lei, Boccaccini and Chen.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Bo Lei, rayboo@xjtu.edu.cn; Aldo R. Boccaccini, aldo.boccaccini@fau.de; Xiaofeng Chen, chenxf@scut.edu.cn
This article was submitted to Nanoscience, a section of the journal Frontiers in Chemistry
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.