ORIGINAL RESEARCH article
Front. Chem.
Sec. Theoretical and Computational Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1642191
Decoding JFT: A Multifunctional Fluorescence Probe for Sulfite and Viscosity Insights
Provisionally accepted
- 1department of physics, Tianjin University Renai College, Tianjin, China
- 2Jinzhou Medical University, Jinzhou, China
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This study focuses on a multifunctional fluorescence probe JFT based on the FRET (Fluorescence Resonance Energy Transfer) and TICT (Twisted Intramolecular Charge Transfer) mechanism. JFT combines an electron donor and an acceptor, enabling it to detect sulfite and monitor intracellular viscosity. When reacting with sulfite, its electronic structure changes, turning off FRET and altering fluorescence wavelength and intensity. In different viscosity environments, the rotation of carbon-carbon bonds in the electron acceptor structure of JFT varies, affecting non-radiative transition pathways and fluorescence intensity. Theoretical calculations based on TDDFT reveal the electron distribution changes before and after the reaction with sulfite species, consistent with experimental phenomena. These findings deepen the understanding of the FRET mechanism of fluorescence probes and offer theoretical guidance for the design of more efficient fluorescence probes.
Keywords: multifunctional, Fluorescent probe, sulfite, intracellular viscosity, theoretical investigation
Received: 06 Jun 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Han, Peng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yongjin Peng, Jinzhou Medical University, Jinzhou, China
Yuling Liu, Jinzhou Medical University, Jinzhou, China
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