REVIEW article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1644192
This article is part of the Research TopicMedicinal and edible TCMs: Extraction and Isolation, Structural Elucidation, Pharmacological Evaluation, Structural Modification, and Quality ControlView all 8 articles
Research Progress on the Chemical Composition of Galli Gigeriae Endothelium Corneum
Provisionally accepted
- 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- 2Guangdong Pharmaceutical University, Guangzhou, China
- 3Guizhou Province Zunyi City Suiyang County Hospital of Traditional Chinese Medicine, Zunyi, China
- 4Guangdong Women and Children Hospital, Guangzhou, China
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Galli Gigeriae Endothelium Corneum (GGEC), commonly known as "Ji Nei Jin" in traditional Chinese medicine (TCM), is derived from the dried inner lining of the chicken gizzard. It has been widely used for centuries in China for treating indigestion, enuresis, gallstones, and urinary calculi. Recent studies have revealed that GGEC contains a variety of bioactive constituents, including proteins, amino acids, peptides, enzymes, and trace elements, which contribute to its diverse pharmacological activities. Modern pharmacological investigations have demonstrated its efficacy in promoting gastrointestinal motility, enhancing digestive enzyme activity, regulating glucose metabolism, dissolving stones, and exerting anti-inflammatory and hepatoprotective effects. Moreover, clinical and experimental research has supported its potential as an adjunct in treating metabolic and digestive disorders. Despite these promising findings, limitations such as unclear mechanisms of action, lack of standardized preparations, and insufficient clinical trials hinder its broader application. This review aims to summarize the traditional uses, chemical constituents, pharmacological activities, and current research progress of GGEC, and to provide a reference for future studies and clinical utilization.
Keywords: Galli gigeriae endothelium corneum, Traditional Chinese Medicine, Pharmacological activities, bioactive components, Chemical constituents
Received: 10 Jun 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Gan, Zhou, Lin, Li, Lin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing-Jin Lin, Guangdong Women and Children Hospital, Guangzhou, China
Zhang Li, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.