Medicinal and edible TCMs: Extraction and Isolation, Structural Elucidation, Pharmacological Evaluation, Structural Modification, and Quality Control

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ORIGINAL RESEARCH

Accepted on 07 Oct 2025

Elucidating the Phytochemical Profile of Sophorae Flavescentis Radix-Astragali Radix Herb Pair: An Integrated LC-QTOF-MS/MS, Pharmacological Activity, and Network Pharmacology Study on Anti-Hepatocellular Carcinoma Effects

Yidi Yin
Jiameng Qu
Lanzhuo Qu
Zhiyuan Li
Huarong Xu
Qing Li

doi 10.3389/fchem.2025.1687098

259 views

MINI REVIEW

Published on 01 Oct 2025

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

Yuanyuan Wu
Hui Huang
Xianglong Zhao
Junhao Lin
Jialiang Guo
Zhengjin Jiang
Kesara Ar-Sanork
Tao Deng
Dongsheng Xu

doi 10.3389/fchem.2025.1694998

1,808 views

REVIEW

Accepted on 29 Sep 2025

Shaoyao Gancao Decoction: A Comprehensive Review of Modern Clinical Applications and Underlying Pharmacological Mechanisms

Du Hong
英 Xiao

doi 10.3389/fphar.2025.1656217

121 views

ORIGINAL RESEARCH

Published on 22 Sep 2025

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

Ronghua Ni
Jisu Qin
Wenyi Wu
Jinqiu Xu
Qunfeng Luo
Liangliang Cai

doi 10.3389/fchem.2025.1659507

2,577 views

ORIGINAL RESEARCH

Accepted on 09 Sep 2025

Development and Validation of a Robust Stability-Indicating Reversed Phase High Performance Liquid Chromatography (RP-HPLC) Method for Simultaneous Quantification of Brimonidine Tartrate and Timolol Maleate (Combigan®) in Bulk and Pharmaceutical Dosage Forms

Aktham Mestareehi

doi 10.3389/fchem.2025.1678541

833 views

ORIGINAL RESEARCH

Published on 03 Sep 2025

UHPLC-HRMS analysis combined with feature-based molecular networking methods for systematic identification of chemicals in AnShenDingZhiLing and its absorbed metabolites

Tai Han
Deqing Ni
Wanqing Zhu
Dan Fang
An Kang
Yumiao Wu
Jichao Sun

doi 10.3389/fchem.2025.1647159

1,478 views

ORIGINAL RESEARCH

Published on 28 Aug 2025

Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigate Clostridium difficile-associated diarrhea in mice

Fu-Zhi Ma
Lin Zhu
Meng Li
Ze-Wei Tang
Xiao-Hong Yu
Cong-En Zhang
Zhi-Jie Ma

doi 10.3389/fchem.2025.1635781

1,477 views

ORIGINAL RESEARCH

Published on 22 Aug 2025

Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer

Fuqin Yang
Zeqiao Li
Haishan Zhang
Mingxiao Zhang
Zhenwei He
Xiaoqin Zheng
Yingru Zhu
Pei Long
Ruirui Ding
1 more
Lijuan Deng

doi 10.3389/fchem.2025.1650197

1,922 views

REVIEW

Published on 23 Jul 2025

Research progress on the chemical composition of galli gigeriae endothelium corneum

Guo-Lian Gan
Hongxin Zhou
Zhen-Bin Lin
Xiang Li
Jing-Jin Lin
Li Zhang

doi 10.3389/fchem.2025.1644192

1,352 views

ORIGINAL RESEARCH

Published on 21 Jul 2025

Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome

Xinxin Mao
Shuqing Shi
Chunmei Chen
Yumeng Li
Bingxuan Zhang
Qingqiao Song

doi 10.3389/fchem.2025.1617676

1,545 views
1 citation

ORIGINAL RESEARCH

Published on 18 Jul 2025

MicroRNA-31 mediated inhibition of keratin 6 by PSORI-CM01: a novel approach to psoriasis amelioration

Shilei Wang
Jingkai Wang
Helin Pan
Ruogu Yang
Fanli Zeng
Yongfei Fang
Jinwei Zhang

doi 10.3389/fchem.2025.1636529

1,484 views

ORIGINAL RESEARCH

Published on 30 May 2025

Black ginseng under forest as a natural antidepressant: insights into its active components and mechanisms

Yixuan Sui
Yiying Tan
Yajing Li
Xiaochen Gao
Han Lu
Jiaming Shen
Xuesheng Hu
Lei Wang
Liting Zhao
1 more
Chunnan Li

doi 10.3389/fchem.2025.1619060

1,456 views

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Medicinal and Pharmaceutical Chemistry

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Articles

Elucidating the Phytochemical Profile of Sophorae Flavescentis Radix-Astragali Radix Herb Pair: An Integrated LC-QTOF-MS/MS, Pharmacological Activity, and Network Pharmacology Study on Anti-Hepatocellular Carcinoma Effects

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

Shaoyao Gancao Decoction: A Comprehensive Review of Modern Clinical Applications and Underlying Pharmacological Mechanisms

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

Development and Validation of a Robust Stability-Indicating Reversed Phase High Performance Liquid Chromatography (RP-HPLC) Method for Simultaneous Quantification of Brimonidine Tartrate and Timolol Maleate (Combigan®) in Bulk and Pharmaceutical Dosage Forms

UHPLC-HRMS analysis combined with feature-based molecular networking methods for systematic identification of chemicals in AnShenDingZhiLing and its absorbed metabolites

Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigate Clostridium difficile-associated diarrhea in mice

Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer

Research progress on the chemical composition of galli gigeriae endothelium corneum

Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome

MicroRNA-31 mediated inhibition of keratin 6 by PSORI-CM01: a novel approach to psoriasis amelioration

Black ginseng under forest as a natural antidepressant: insights into its active components and mechanisms

Frontiers in Chemistry

Medicinal and Pharmaceutical Chemistry