ORIGINAL RESEARCH article
Front. Chem.
Sec. Organic Chemistry
Ultrasonic-Assisted, Additive-Free Pd-Catalyzed Suzuki-Miyaura Cross-Coupling Enabled Synthesis of Novel Arylated Benzofuran-Triazole Hybrids
Provisionally accepted
Muhammad Jawwad Saif1
Sajjad Ahmad2
Aqsa Mushtaq1Saba Munawar1
Ameer Fawad Zahoor3*Shoela Ettampola4
Dr. Ali Irfan1Katarzyna Kotwica-Mojzych5Karol Ruszel6Mariusz Mojzych6- 1Government College University Faisalabad, Faisalabad, Pakistan
- 2University of Engineering and Technology, Lahore, Pakistan
- 3Government College University, Faisalabad, Faisalabad, Pakistan
- 4Dunwoody High School, Dunwoody, United States
- 5Uniwersytet Medyczny w Lublinie, Lublin, Poland
- 6Akademia Mazowiecka w Plocku, Plock, Poland
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An additive-free and ultrasound assisted approach has been established for the Suzuki-Miyaura cross-coupling reaction between substituted boronic acid and benzofuran-endowed aryl halides by employing the catalytic amount of Pd(PPh3)4. The resulting substituted biaryls were then employed as efficient starting materials to furnish a novel library of arylated benzofuran-triazole hybrids 13(a-i). The method offers a facile, efficient, non-inert conditions and less-time consuming approach to synthesize the targeted derivatives in good to excellent yield range i.e., 70-92%.
Keywords: suzuki reaction, Pd(PPh3)4, ultrasound, arylated benzofuran-triazole hybrids, Heterocycles
Received: 16 Oct 2025; Accepted: 11 Nov 2025.
Copyright: © 2025 Saif, Ahmad, Mushtaq, Munawar, Zahoor, Ettampola, Irfan, Kotwica-Mojzych, Ruszel and Mojzych. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ameer Fawad Zahoor, fawad.zahoor@gcuf.edu.pk
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