ORIGINAL RESEARCH article
Front. Chem.
Sec. Organic Chemistry
Deaminative Methylselenation of Anlines with PhSO2SeCH3
Limei Wang 1
Bo Zhang 2
Yan Yan 1
Lijuan Liu 2
Ge Ou 2
Ning Xiao 2
1. FAW General Hospital, Changchun, China
2. Jilin Province FAW General Hospital, Changchun, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract
Herein, we present a method for methylselenation of aryldiazonium salts that does not require metals or acids, achieved by directly transforming an amino group into a methylseleno group. This strategy is compatible with diverse anilines and facilitates rapid late-stage methylselenation of key pharmaceuticals and their derivatives, clearly demonstrating the utility of PhSO2SeCH3 as a methylselenation reagent. Mild reaction conditions proceed efficiently at a 100 mmol scale, allowing double methylselenation of anilines and concise construction of aryl-SeCD₃.
Summary
Keywords
Acid-free, Anilines, Deamination, Metal-free, methylselenation
Received
07 December 2025
Accepted
17 February 2026
Copyright
© 2026 Wang, Zhang, Yan, Liu, Ou and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ning Xiao
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.