Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 29 Apr 2025

Proposal of a new chemical marker for the quality control of the herb Scleromitrion diffusum

in Medicinal and Pharmaceutical Chemistry

Tao Zheng
Chu-Chu Zhong
Grace Gar-Lee Yue
Dong-Min Jiang
Man-Ho Tong
Hiu-Yan Wong
Kwan-Ho Wong
Meng-Hua Wu
David Tai-Wai Lau
Hui Cao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600769

1,909 views

Review

Published on 29 Apr 2025

Modification of biopharmaceutical parameters of flavonoids: a review

in Medicinal and Pharmaceutical Chemistry

Amir Taldaev
Artem A. Svotin
Semyon I. Obukhov
Roman P. Terekhov
Irina A. Selivanova

Frontiers in Chemistry

doi 10.3389/fchem.2025.1602967

2,825 views
3 citations

Original Research

Published on 25 Apr 2025

Chemical profile of Rhododendron luteum Sweet leaf supercritical CO2 extracts and their anti-inflammatory and antidiabetic potential

in Medicinal and Pharmaceutical Chemistry

Lena Łyko
Renata Nowak
Marta Olech
Urszula Gawlik
Agnieszka Krajewska
Danuta Kalemba
Andriy Prokopiv

Frontiers in Chemistry

doi 10.3389/fchem.2025.1576852

1,995 views

Mini Review

Published on 25 Apr 2025

The quinoline framework and related scaffolds in natural products with anti-Leishmania properties

in Medicinal and Pharmaceutical Chemistry

Gloria Yaluff
Leídi Herrera
Miriam Soledad Rolón
Celeste Vega
Hugo Cerecetto

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571067

3,499 views
4 citations

Original Research

Published on 25 Apr 2025

Effect of freeze-pressure regulated extraction technology on the physicochemical properties and pharmacological activities of guizhi extract

in Medicinal and Pharmaceutical Chemistry

Huiling Zhang
Juanzhen Luo
Qinzhao Wan
Xuecheng Wang
Zhenfeng Wu
Ming Yang
Yaqi Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581429

1,509 views

Original Research

Published on 22 Apr 2025

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

in Medicinal and Pharmaceutical Chemistry

Jinchao Zhu
Qingyuan Lin
Honglin Zhu
Siqi Xie
Shengdong Nie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1584588

4,154 views
1 citation

Original Research

Published on 16 Apr 2025

Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis

in Medicinal and Pharmaceutical Chemistry

Eva Azme
Md. Mahmudul Hasan
Md. Liakot Ali
Rashedul Alam
Neamul Hoque
Fabiha Noushin
Mohammed Fazlul Kabir
Ashraful Islam
Tanzina Sharmin Nipun
S. M. Moazzem Hossen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1527008

4,300 views
4 citations

Original Research

Published on 16 Apr 2025

Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Ali M. Elshamsy
Taha F. S. Ali
Bahaa G. M. Youssif
Stefan Bräse
Mohamed Abdel-Aziz
Nawal A. El-Koussi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1565699

11,847 views
2 citations

Review

Published on 16 Apr 2025

Research progress on extraction, separation, structure, and biological activities of polysaccharides from jujube fruit (Ziziphus jujuba Mill.): a review

in Medicinal and Pharmaceutical Chemistry

Feilong Jia
Bo Wang
Hui Ma
Changcai Bai
Yuanyuan Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581947

2,610 views
1 citation

Original Research

Published on 10 Apr 2025

Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS/MS profiled extract from Capparis spinosa L

in Medicinal and Pharmaceutical Chemistry

Amjad Ibrahim Oraibi
Ashour H. Dawood
Ghada Trabelsi
Ousman B. Mahamat
Leila Chekir-Ghedira
Soumaya Kilani-Jaziri

Frontiers in Chemistry

doi 10.3389/fchem.2025.1540174

2,817 views
1 citation

Original Research

Published on 04 Apr 2025

Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity

in Medicinal and Pharmaceutical Chemistry

Hamada Hashem
Shadwa Abdelfattah
Hesham M. Hassan
Ahmed Al-Emam
Mohammed Alqarni
Ghallab Alotaibi
Ibrahim Taha Radwan
Kirandeep Kaur
Devendra Pratap Rao
Stefan Bräse

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571646

2,974 views

Mini Review

Published on 01 Apr 2025

4-Aminoquinoline: a comprehensive review of synthetic strategies

in Medicinal and Pharmaceutical Chemistry

Francisco Delgado
Andrés Benítez
Lourdes Gotopo
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1553975

7,033 views
4 citations

Original Research

Published on 01 Apr 2025

Healing and leishmanicidal activity of Zanthoxylum rhoifolium Lam.

in Medicinal and Pharmaceutical Chemistry

Juliana Correa-Barbosa
Heliton Patrick Cordovil Brígido
Bibiana Franzen Matte
Paloma Santos De Campos
Marcelo Lazzaron Lamers
Daniele Ferreira Sodré
Pedro Henrique Costa Nascimento
Gleison Gonçalves Ferreira
Valdicley Vieira Vale
Andrey Moacir do Rosário Marinho

Frontiers in Chemistry

doi 10.3389/fchem.2025.1504998

1,416 views

Original Research

Published on 28 Mar 2025

Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

in Medicinal and Pharmaceutical Chemistry

Yongzhi He
Jiachun Lu
Yushan Luo
Rizhao Pang
Xiaoming Hu
Lijuan Ding
Hua Xiao
Yunyun Wang
Wenchun Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1568551

2,653 views
2 citations

Original Research

Published on 28 Mar 2025

Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists

in Medicinal and Pharmaceutical Chemistry

Hua Jiang
Haowei Chen
Ya Wang
Huaxin Xu
Hong Chen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1557275

3,056 views

Original Research

Published on 26 Mar 2025

Structure-based identification of bioactive phytochemicals targeting kallikrein-related peptidase 2 for prostate cancer therapy

in Medicinal and Pharmaceutical Chemistry

Deeba Shamim Jairajpuri
Afzal Hussain
Mohamed F. Alajmi
Taj Mohammad
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1553987

2,686 views
1 citation