Frontiers in Immunology

Original Research

Accepted on 11 Dec 2025

A Shikonin-Based Hydrogel Dressing Exhibiting Synergistic Anti-Inflammatory, Anti-Angiogenic, and Anti-Fibrotic Effects for the Prevention of Hypertrophic Scars

in Vaccines and Molecular Therapeutics

Ziyu Wang
Yujie Zhao
Zhoujiang Qu
Hui Wang
Yuling Zhang
Yufang Liu
Chengde Li
Kun Wang
Guoqi Cao

Frontiers in Immunology

Original Research

Published on 11 Dec 2025

IL-33-mediated mast cell and eosinophil function requires isoprenylation

in Cytokines and Soluble Mediators in Immunity

Jason R. Burchett
Aditya Kotha
Destiny T. Davis
Kaitlyn G. Jackson
Jordan M. Dailey
Tania D. Maldonado
Tamara T. Haque
Zakaria Y. Hussain
John M. Ching
Pamela Frischmeyer-Guerrerio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662170

775 views

Original Research

Published on 11 Dec 2025

Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation

in Inflammation

Linling Du
Jie Pan
Nan Xu
Feng Yan
Weiyi Tian
Qiyan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705047

645 views

Original Research

Published on 11 Dec 2025

The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds

in Comparative Immunology

Christina N. Garvey Griffith
Kelsey A. Hauser
Bradley Abramson
Elissa R. Chapkin
Elizabeth J. Jones
Anju N. Duttargi
Leon Grayfer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713361

519 views

Brief Research Report

Published on 11 Dec 2025

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

in Molecular Innate Immunity

Sruthi Vijaya Retnakumar
Suraj Chandrabhan Singh
Camille Chauvin
Jagadeesh Bayry

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718240

482 views

Original Research

Published on 11 Dec 2025

Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation

in Alloimmunity and Transplantation

Lijie Ma
Shiming Gong
Jianchen Fang
Mingxuan Feng
Zhenzhen Zhan
Qiang Xia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728290

470 views

Review

Published on 11 Dec 2025

Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation

in Multiple Sclerosis and Neuroimmunology

Qingqing Tang
Min He
Peng Zheng
Mengmeng Sun
Jiazhen Cao
Qi Zhang
Jing He
Run Sun
Bing Zhu
Tie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700282

650 views

Original Research

Published on 11 Dec 2025

Glymphatic dysfunction in neuromyelitis optica spectrum disorder

in Multiple Sclerosis and Neuroimmunology

Ying Zhang
Hongxi Chen
Ziyan Shi
Rui Wang
Xiaofei Wang
Qin Du
Yuntao Mo
Shixiang Chen
Hongyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698986

579 views

Mini Review

Published on 11 Dec 2025

Targeting glial cell pyroptosis and neuroinflammation in post-stroke depression: from molecular mechanisms to therapeutic strategies

in Inflammation

Xinyao Li
Yuanyuan Wei
Yuqing She
Wenjuan Long
Sitong Zhou
Mingqin Shi
Zihui Wang
Xuelian Zou
Jianqin Mao
Xiangdian Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677221

461 views

Original Research

Published on 11 Dec 2025

Autoantibodies in long COVID in a black/mixed population compared with recovered and pre-pandemic controls

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jessica de Jesus Silva
Laila Sampaio Horta
Sayonara Melo Viana
Ana Beatriz Cazé
Isabela S. Oliveira
Mariana M. Pereira
Natalie Antas Nascimento
Blenda de Jesus Pereira
Ícaro Bonyek-Silva
Sara Nunes de Oliveira Araújo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684482

479 views

Correction

Published on 11 Dec 2025

Correction: GATA2 deficiency in an adult with alveolar proteinosis, infections, lymphadenopathy with granulomatosis, and immune deficiency: case report

in Primary Immunodeficiencies

Juliana Gabzdilová
Štefan Raffáč
Gabriela Krasňanská
Michal Konečný

Frontiers in Immunology

doi 10.3389/fimmu.2025.1750971

170 views

Original Research

Published on 11 Dec 2025

Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

in Molecular Innate Immunity

Mengkui Han
Junchi Xu
Xunxun Wu
Zhiqing Hu
Xiaoyuan Hu
Xiaolong Zhu
Cailin Chen
Qinkao Xuan
Yang Li
Chuanwu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671149

393 views

Original Research

Published on 11 Dec 2025

Vinegar intake in patients undergoing immune checkpoint inhibitor therapy: food frequency questionnaire study

in Cancer Immunity and Immunotherapy

Hirotsugu Ariizumi
Miyuki Shimazui
Chisato Ogawa
Mika Kaneki
Nanaho Saito
Emiko Mura
Risako Suzuki
Toshiaki Tsurui
Nana Iriguchi
Tomoyuki Ishiguro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640603

535 views

Original Research

Published on 11 Dec 2025

Prognostic significance of reduced handgrip strength in patients with unresectable hepatocellular carcinoma receiving HAIC combined with targeted immunotherapy

in Cancer Immunity and Immunotherapy

Xin-Ze Wang
Ping Wang
Xing Lv
Zi-Long Zhang
Er-Lei Zhang
Gui-Bao Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672519

293 views

Review

Published on 11 Dec 2025

Unraveling the RKIP–YY1 axis: immune crosstalk in the pathogenesis of metabolic disorders

in Inflammation

Fawaz Alzaid
Hossein Arefanian
Fatemah Bahman
Shaima Albeloushi
Ghadeer Alhamar
Anwar Mohammad
Amal Hasan
Ashraf Al Madhoun
Rasheed Ahmad
Fahd Al-Mulla

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675699

494 views

Original Research

Published on 11 Dec 2025

Peri-tumoural lymphocyte neighbourhoods predict longer survival in pancreatic ductal adenocarcinoma

in Cancer Immunity and Immunotherapy

Riley J. Arseneau
Jorge P. Mejia
Sarah Nersesian
Stacey N. Lee
Carley Bekkers
Thomas Samson
Daniel Gaston
Boris L. Gala-Lopez
Ravi Ramjeesingh
Thomas Arnason

Frontiers in Immunology

doi 10.3389/fimmu.2025.1730817

483 views

Original Research

Published on 11 Dec 2025

MMP-9 affects dural cell composition and granulocyte accumulation during neuroinflammation

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Sheng-Hsiang Shen
Hanna Gerwien
Miriam Burmeister
Yi-Ling Tsang
I-Na Lu
Anna-Lena Börsch
Tushar Deshpande
Lydia Sorokin
Gerd Meyer zu Hörste

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713166

1,297 views

Original Research

Published on 11 Dec 2025

Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022–2025

in Primary Immunodeficiencies

Oksana Boyarchuk
Halyna Makukh
Alla Volokha
Anastasiia Bondarenko
Nataliia Mytsyk
Oksana Barvinska
Ivanna Shymanska
Yuliia Pohuliai
Mykola Veropotvelyan
Anastasia Haviley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709657

614 views

Mini Review

Published on 11 Dec 2025

Intrathecal rituximab for the treatment of Epstein–Barr virus-associated encephalitis

in Viral Immunology

Aude G. Chapuis
Johnnie J. Orozco
Filippo Milano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736017

343 views

Review

Published on 11 Dec 2025

Beneficial effects of food-medicine homologous herbs for patients with diabetic kidney disease

in Nutritional Immunology

Qin Zeng
Wenru Wang
Yihan Li
Ming Wang
Zhengtang Liu
Lei Yan
Jingyi Zhan
Xinhui Wang
Ying Liang
Renhuan Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698240

573 views

Review

Published on 11 Dec 2025

The role of nucleic acid sensors in antifungal immunity

in Microbial Immunology

Xinyu Liang
Hui Zhou
Litong Ouyang
Jiming Chen
Wenji He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725717

389 views

Original Research

Published on 11 Dec 2025

Risk factors for central hypoventilation in anti-N-methyl-D-aspartate receptor encephalitis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xuan Zou
Xi-yue Jing
Guan-en Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718192

276 views

Original Research

Published on 11 Dec 2025

Mitochondrial calcium shapes B cell signaling and mitochondrial function

in B Cell Biology

Hakan Taskiran
Elena Czeslik
Leonhard Stark
Kathrin Kläsener
Theresa Elisa Schnalzger
Jürgen Ruland
Michael Reth
Julia Jellusova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710128

342 views

Mini Review

Published on 11 Dec 2025

Tumor associated macrophages in gastric cancer dual roles in immune evasion and clinical implications for targeted therapy

in Molecular Innate Immunity

Chang Wang
Xu Fan
Xiaomen Sun
Yi Xu
Yanna Sun
Jidong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706744

415 views

48,462 articles

articles

A Shikonin-Based Hydrogel Dressing Exhibiting Synergistic Anti-Inflammatory, Anti-Angiogenic, and Anti-Fibrotic Effects for the Prevention of Hypertrophic Scars

IL-33-mediated mast cell and eosinophil function requires isoprenylation

Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation

The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation

Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation

Glymphatic dysfunction in neuromyelitis optica spectrum disorder

Targeting glial cell pyroptosis and neuroinflammation in post-stroke depression: from molecular mechanisms to therapeutic strategies

Autoantibodies in long COVID in a black/mixed population compared with recovered and pre-pandemic controls

Correction: GATA2 deficiency in an adult with alveolar proteinosis, infections, lymphadenopathy with granulomatosis, and immune deficiency: case report

Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

Vinegar intake in patients undergoing immune checkpoint inhibitor therapy: food frequency questionnaire study

Prognostic significance of reduced handgrip strength in patients with unresectable hepatocellular carcinoma receiving HAIC combined with targeted immunotherapy

Unraveling the RKIP–YY1 axis: immune crosstalk in the pathogenesis of metabolic disorders

Peri-tumoural lymphocyte neighbourhoods predict longer survival in pancreatic ductal adenocarcinoma

MMP-9 affects dural cell composition and granulocyte accumulation during neuroinflammation

Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022–2025

Intrathecal rituximab for the treatment of Epstein–Barr virus-associated encephalitis

Beneficial effects of food-medicine homologous herbs for patients with diabetic kidney disease

The role of nucleic acid sensors in antifungal immunity

Risk factors for central hypoventilation in anti-N-methyl-D-aspartate receptor encephalitis

Mitochondrial calcium shapes B cell signaling and mitochondrial function

Tumor associated macrophages in gastric cancer dual roles in immune evasion and clinical implications for targeted therapy