Frontiers in Immunology | Mucosal Immunity

Original Research

Published on 27 Nov 2025

Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models

in Mucosal Immunity

Xiaolu Chen
Muyao Cui
Jiaqi Li
Qi Chen
Linzhen Chen
Zhuo Yang
Qiqi Fan
Yuhan Sheng
Ruichao Lin
Zhiqiang Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722777

1,485 views

Original Research

Published on 27 Nov 2025

No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study

in Mucosal Immunity

Marisa R. Young
C. Christina Mehta
Tyree Staple
Gina Bailey Herring
Sakthivel Govindaraj
Chris Ibegbu
Betsy C. Herold
Vijayakumar Velu
Lisa B. Haddad
Alicia K. Smith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655678

1,955 views

Original Research

Published on 27 Nov 2025

NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma

in Mucosal Immunity

Stephanie DeStefano
Ruth Grychtol
Dominik Funken
Anika Habener
Stephanie Tamm
Frauke Stanke
Wolfgang Greiner
Kirsten Beyer
Eckard Hamelmann
Michael Kabesch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655205

1,857 views

Review

Published on 26 Nov 2025

Immune-mediated mechanisms and maternal-fetal interface dysfunction in obstetric antiphospholipid syndrome

in Mucosal Immunity

Guangyu Ma
Jinbiao Han
Rui Gao
Lang Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722080

2,349 views
1 citation

Review

Published on 24 Nov 2025

The gut microbiota and its metabolites: novel therapeutic targets for inflammatory bowel disease

in Mucosal Immunity

Xingyu Shen
Yue Li
Deqiang Wang
Kang Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690279

2,353 views
2 citations

Original Research

Published on 19 Nov 2025

Benzo[a]pyrene exacerbates allergen-induced airway inflammation through NLRP3-dependent dendritic cell activation and pathogenic T helper cell polarization

in Mucosal Immunity

Huamei Zou
Jiaqi Duan
Yongmin Xie
Ruien Chen
Yanyu Ye
Aizhi Zhang
Pingchang Yang
Gui Yang
Xiaoyu Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699886

2,191 views

Original Research

Published on 19 Nov 2025

Follicle-like niches outside the cortex? 3D phase-contrast µCT revealed medullary B cell nodules in mucosa-draining lymph nodes

in Mucosal Immunity

Paul Schütz
Florian L. Schwarzenberg
Lennert J. Weber
Jörg U. Hammel
Bente Siebels
Paula Nissen
Nenya Leising
Katja J. Jarick
Bernd Walkenfort
Sarah C. Irvine

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674997

2,737 views

Original Research

Published on 18 Nov 2025

Mendelian randomization integrated with multi-omics analysis identifies TNIK as a key gene in gut microbiota-induced IBD development

in Mucosal Immunity

Xin Chai
Hongli Wang
Boxiang Wang
Yanchun Ma
Xiaoyan Zhang
Jing Guo
Shuping Luo
Yan Wang
Jinpeng Hong
Qiang Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678444

2,472 views

Review

Published on 18 Nov 2025

Molecular mechanisms of neutrophil regulatory network in anti-Candida infection

in Mucosal Immunity

Yanhua Xu
Renyi Cheng
Wen Li
Wenjing Yu
Chider Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716645

3,101 views

Review

Published on 11 Nov 2025

From pathogenic mechanisms to therapeutic perspectives: a review of gut microbiota and intestinal mucosal immunity in inflammatory bowel disease

in Mucosal Immunity

Tianqi Han
Yiwen Zhang
Gang Zheng
Yi Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704651

3,097 views
1 citation

Original Research

Published on 10 Nov 2025

Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome

in Mucosal Immunity

Satoshi Kotani
Yoshiyuki Mishima
Kenichi Kishimoto
Akihiko Oka
Naoki Oshima
Kousaku Kawashima
Kenjiro Matsumoto
Haruki Usuda
Koichiro Wada
Shunji Ishihara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672117

1,810 views

Mini Review

Published on 07 Nov 2025

Depression and anxiety in inflammatory bowel disease: mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis

in Mucosal Immunity

Yan Qian
Yang Chen
Linquan Liu
Tiesong Wu
Xiehui Chen
Guiping Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676160

3,238 views
1 citation

Review

Published on 05 Nov 2025

Gut microbiota and metabolites: emerging prospects in the treatment of non-small cell lung cancer

in Mucosal Immunity

Jing-Mian Jiao
Chen-Guang Liu
Dan Zang
Jun Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638942

2,442 views

Original Research

Published on 05 Nov 2025

Hookworm infection modulates lung and intestinal transcriptomic responses to SARS-CoV-2 in Syrian hamsters

in Mucosal Immunity

Bruce A. Rosa
Mahdiyeh Bigham
Tamarand L. Darling
Ashutosh Arun
Kumar Sachin Singh
John Martin
Adrianus C. M. Boon
Makedonka Mitreva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701728

2,214 views

Review

Published on 04 Nov 2025

The gut–lung axis: a new perspective on the impact of atmospheric particulate matter exposure on chronic obstructive pulmonary disease

in Mucosal Immunity

Xichen Pang
Ping Huang
Sha Huang
Xiaoju Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657675

2,726 views

Correction

Published on 03 Nov 2025

Correction: Discovery of protease inhibitors from bacteria as novel adjuvants for oral vaccine formulations

in Mucosal Immunity

Lorena M. Coria
Celeste Pueblas Castro
Laura Bruno
Helder I. Nakaya
Karina A. Pasquevich
Juliana Cassataro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731676

768 views

Original Research

Published on 03 Nov 2025

Probiotic Weissella cibaria LAB_Weis_Camel_L4 mitigates Escherichia coli-induced enteritis via competitive exclusion and microbiota modulation

in Mucosal Immunity

Wanjing Jin
Mengfei Zhang
Xueqin Lan
Ying Huang
Yixin Bai
Yingchao Li
Chenyang Shi
Yaolong Song
Lei Wang
Yi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642209

1,820 views

Original Research

Published on 03 Nov 2025

Lymphocytes and immunoglobulins in peripheral blood and lymphatic fluid of neonates with chylothorax

in Mucosal Immunity

Domenico Umberto De Rose
Francesca Landolfo
Flaminia Pugnaloni
Fatima Zahra Gassabi
Ludovica Martini
Alessandra Santisi
Claudia Columbo
Paola Giliberti
Fabia Gazzotti
Ottavia Porzio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666366

1,364 views

Review

Published on 30 Oct 2025

Genes, guts, and microbes: decoding host-driven microbial regulation using intestine-specific conditional knockouts

in Mucosal Immunity

Priyankar Dey

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674913

2,220 views
3 citations

Original Research

Published on 30 Oct 2025

LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion

in Mucosal Immunity

Sharmina Deloer
Ivan Fuss
Portia Gough
Anketse Debebe
Mellissa Picker
Robert J. Devita
Inga Peter
Warren Strober

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675137

2,064 views

Editorial

Published on 29 Oct 2025

Editorial: Pulmonary immunity: role of inducible bronchus-associated lymphoid tissue in lung diseases

in Mucosal Immunity

Zhong-Min Ma
Rachel Reader

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725281

954 views

Editorial

Published on 28 Oct 2025

Editorial: Host-microbiota immuno-interactions for personalized microbial therapeutics

in Mucosal Immunity

Shashank Gupta
Sunil Kumar Raghav
Nar Singh Chauhan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716098

951 views

Editorial

Published on 24 Oct 2025

Editorial: Mucosal microbiota immunomodulation of the gut-lung axis

in Mucosal Immunity

Yuseok Moon
Susanta Pahari
Shikha Negi
Evelyn Tsantikos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721724

1,808 views

Original Research

Published on 22 Oct 2025

Study on dynamic alterations of plasma lipid profiles during disease progression in combined allergic rhinitis and asthma syndrome based on lipidomics

in Mucosal Immunity

Yanmin Shi
Yiting Li
Zifan Cheng
JiaJia Wang
Suyun Li
Yang Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666214

2,230 views

1,024 articles

articles

Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models

No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study

NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma

Immune-mediated mechanisms and maternal-fetal interface dysfunction in obstetric antiphospholipid syndrome

The gut microbiota and its metabolites: novel therapeutic targets for inflammatory bowel disease

Benzo[a]pyrene exacerbates allergen-induced airway inflammation through NLRP3-dependent dendritic cell activation and pathogenic T helper cell polarization

Follicle-like niches outside the cortex? 3D phase-contrast µCT revealed medullary B cell nodules in mucosa-draining lymph nodes

Mendelian randomization integrated with multi-omics analysis identifies TNIK as a key gene in gut microbiota-induced IBD development

Molecular mechanisms of neutrophil regulatory network in anti-Candida infection

From pathogenic mechanisms to therapeutic perspectives: a review of gut microbiota and intestinal mucosal immunity in inflammatory bowel disease

Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome

Depression and anxiety in inflammatory bowel disease: mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis

Gut microbiota and metabolites: emerging prospects in the treatment of non-small cell lung cancer

Hookworm infection modulates lung and intestinal transcriptomic responses to SARS-CoV-2 in Syrian hamsters

The gut–lung axis: a new perspective on the impact of atmospheric particulate matter exposure on chronic obstructive pulmonary disease

Correction: Discovery of protease inhibitors from bacteria as novel adjuvants for oral vaccine formulations

Probiotic Weissella cibaria LAB_Weis_Camel_L4 mitigates Escherichia coli-induced enteritis via competitive exclusion and microbiota modulation

Lymphocytes and immunoglobulins in peripheral blood and lymphatic fluid of neonates with chylothorax

Genes, guts, and microbes: decoding host-driven microbial regulation using intestine-specific conditional knockouts

LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion

Editorial: Pulmonary immunity: role of inducible bronchus-associated lymphoid tissue in lung diseases

Editorial: Host-microbiota immuno-interactions for personalized microbial therapeutics

Editorial: Mucosal microbiota immunomodulation of the gut-lung axis

Study on dynamic alterations of plasma lipid profiles during disease progression in combined allergic rhinitis and asthma syndrome based on lipidomics