Frontiers in Immunology | Systems Immunology

Original Research

Published on 08 Jul 2025

Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis

in Systems Immunology

Monika Golinska
Aleksander Rycerz
Matylda Sobczak
Jedrzej Chrzanowski
Konrad Stawiski
Wojciech Fendler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619434

5,200 views
3 citations

Original Research

Published on 03 Jul 2025

CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation

in Systems Immunology

Juan Juan Chen
Zhang Ze Lu
Yu Xin Jing
Xing Mei Nong
Yi Qin
Jin Yang Huang
Na Lin
Jie Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609183

3,973 views
2 citations

Original Research

Published on 02 Jul 2025

Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis

in Systems Immunology

Chunyang Li
Haiyan Xue
Lihe Chen
Fengxue Zhu
Jie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608082

3,217 views

Original Research

Published on 02 Jul 2025

Prediction and immune landscape study of potentially key autophagy-related biomarkers in preeclampsia with gestational diabetes mellitus

in Systems Immunology

Qin Wang
Xiaoqi Li
Wen Ye
Lin Lin
Kejun Ye
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571795

4,771 views
1 citation

Original Research

Published on 02 Jul 2025

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

in Systems Immunology

Yuxiang Chi
Guoyuan Ma
Qiang Liu
Yunzhi Xiang
Defeng Liu
Jiajun Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608407

6,043 views
1 citation

Original Research

Published on 27 Jun 2025

Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis

in Systems Immunology

Liangzhe Wang
Bo Wang
Min Peng
Xiaoyan Yang
Sijia Huang
Ruixin Wang
Lin Du
Ruiqian Yao
Wei Wang
Baiping Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545457

3,323 views
1 citation

Original Research

Published on 26 Jun 2025

Integrative bioinformatics and machine learning approaches reveal oxidative stress and glucose metabolism related genes as therapeutic targets and drug candidates in Alzheimer’s disease

in Systems Immunology

Fatima Noor
Sidra Aslam
Ignazio S. Piras
Cecilia Tremblay
Thomas G. Beach
Geidy E. Serrano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572468

3,661 views
1 citation

Original Research

Published on 26 Jun 2025

Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

in Systems Immunology

Shuaiwei Wang
Hao Fu
Xiaoqing Li
Hongrui Xu
Yu Bai
Wenjun Jiang
Xiaozhe Cheng
Na Chen
Yijie Zhang
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624014

3,002 views

Original Research

Published on 24 Jun 2025

Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing

in Systems Immunology

Haoyue Wang
Dongdong Wu
Gangfei Han
Jingjing Yan
Zehui Wang
Xing He
Yuxiang Chen
Yan Wang
Qinghua Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560903

6,175 views
2 citations

Original Research

Published on 18 Jun 2025

CAR-T cell therapy for glioblastoma: insight from mathematical modeling

in Systems Immunology

Magdalena Szafrańska-Łęczycka
Zuzanna Szymańska
Monika J. Piotrowska
Marek Bodnar
Urszula Foryś

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563829

4,492 views
1 citation

Original Research

Published on 16 Jun 2025

Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD

in Systems Immunology

Lanlan Liu
Mei Zhou
Shengwen Sun
Long Chen
Dehu Li
Jiaxi Lv
Rui Cheng
Jianchu Zhang
Jianghua Wu
Xianzhi Xiong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614655

5,086 views
1 citation

Original Research

Published on 12 Jun 2025

Hematopoietic effects of Fufang E’jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy

in Systems Immunology

Yueting Mo
Xiyuan He
Peixin Shi
Yifei Ning
Mingmei Zhou
Hao Cui
Ting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561477

4,569 views

Original Research

Published on 10 Jun 2025

Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing

in Systems Immunology

Yongfen Huang
Ping Yi
Yixuan Wang
Lingling Wang
Yongqin Cao
Jingbo Lu
Kun Fang
Yuexin Cheng
Yuqing Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565954

3,757 views
1 citation

Original Research

Published on 10 Jun 2025

Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations

in Systems Immunology

Xiaohong Lyu
Yi Liu
Huaijun Zheng
Hongna Li
Zhoujie Wu
Yi Sun
Shanhong Wu
Xuehan Jiang
Shandong Wu
Rui Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555664

3,628 views

Original Research

Published on 09 Jun 2025

Inflammatory markers in pregnancy – identifying drivers in four large cohorts

in Systems Immunology

Frederieke A. J. Gigase
Anna Suleri
Elena Isaevska
Anna-Sophie Rommel
Myrthe G. B. M. Boekhorst
Olga Dmitrichenko
Hanan El Marroun
Eric A. P. Steegers
Manon H. J. Hillegers
Ryan L. Muetzel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561798

3,927 views
2 citations

Original Research

Published on 09 Jun 2025

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction

in Systems Immunology

Jingjing Chen
Dan Zhang
Chengxiu Zhu
Lin Lin
Kejun Ye
Ying Hua
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595222

4,119 views
1 citation

Original Research

Published on 05 Jun 2025

Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment

in Systems Immunology

Anisha Datta
Laura C. Bahlmann
Diana N. Gong
Erin N. Tevonian
James B. Lorens
Douglas A. Lauffenburger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601420

4,668 views
2 citations

Original Research

Published on 05 Jun 2025

Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis

in Systems Immunology

Eiko Uno
Florence Kim
Mihoko Yoshino
Yasunari Sato
Masao Hashimoto
Kenji Watanabe
Yoichi Mizukami
Jun Muto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592751

4,072 views

Original Research

Published on 05 Jun 2025

Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation

in Systems Immunology

Huan Ma
Xiayan Qian
Xiaodong Song
Rongjie Jiang
Jialin Li
Fang Xiao
Ruoxu Dou
Xiangdong Guan
Ka Yin Lui
Shuhe Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610519

4,802 views
3 citations

Original Research

Published on 03 Jun 2025

Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections

in Systems Immunology

Hao Xing
Junlin Pan
Huan Liu
Yanan Wang
Zhengqi Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600194

2,343 views

Systematic Review

Published on 02 Jun 2025

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review

in Systems Immunology

Xianghui Zhao
Peiying Lv
Zixing Cai
Jun Dong
Wenxiang Chen
Liang Sun
Ruiyue Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579924

6,139 views
3 citations

Original Research

Published on 30 May 2025

KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification

in Systems Immunology

Nan Zhang
Shishun Zhao
Runze Wu
Xizi Luo
Ming Yang
Zecheng Chang
Jianting Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602907

2,176 views

Editorial

Published on 30 May 2025

Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies

in Systems Immunology

Ying Zhu
Veronica G. Anania
Jennie R. Lill
Zora Modrusan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628120

2,947 views

Perspective

Published on 29 May 2025

Multi-physiology modeling of the immune system in the era of precision immunotherapy

in Systems Immunology

Sunghyun Hong
Kyemyung Park

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548768

3,535 views

545 articles

articles

Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis

CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation

Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis

Prediction and immune landscape study of potentially key autophagy-related biomarkers in preeclampsia with gestational diabetes mellitus

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis

Integrative bioinformatics and machine learning approaches reveal oxidative stress and glucose metabolism related genes as therapeutic targets and drug candidates in Alzheimer’s disease

Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing

CAR-T cell therapy for glioblastoma: insight from mathematical modeling

Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD

Hematopoietic effects of Fufang E’jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy

Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing

Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations

Inflammatory markers in pregnancy – identifying drivers in four large cohorts

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction

Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment

Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis

Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation

Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review

KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification

Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies

Multi-physiology modeling of the immune system in the era of precision immunotherapy