ORIGINAL RESEARCH article
Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Volume 12 - 2025 | doi: 10.3389/fmats.2025.1570738
This article is part of the Research TopicBiodegradable Polymers for Biomedical Applications - Volume IVView all 3 articles
Nanopore Structure of PLA@SF Aligned Composite electrospun Fiber Membrane Enhances Growth Behavior of Peripheral Nerve Cells
Provisionally accepted
- 1Department of Orthopedic, Nantong Traditional Chinese Medicine Hospital, Nantong，Jiangsu Province,, China
- 2Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
- 3Nantong Traditional Chinese Medicine Hospital, Nantong, Jiangsu Province, China
- 4Wuxi Traditional Chinese Medicine Hospital, Wuxi, Jiangsu Province, China
- 5Nantong Hospital of Traditional Chinese Medicine, Nantong, China
- 6Nantong Traditional Chinese Medicine Hospital, Nantong, Jiangsu Province,, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Optimizing the physical microstructure of nerve grafts and enhancing their biological functions to create a microenvironment that favors the regeneration of damaged nerves can significantly improve the recovery of damaged nerve function. Fibers constructed using electrospinning technology can effectively replicate the 3D skeleton of the extracellular matrix (ECM). The impact of the porous characteristics of the fiber surface on cellular growth behavior has attracted considerable attention from researchers. However, there are few studies that have explored the synergistic influence of fiber surface nanotopology and silk fibroin (SF) on peripheral nerve cell growth patterns. In this paper, we present a polylactic acid (PLA)/silk fibroin (SF) composite fiber membrane featuring a nanopore structure on its surface. The following tests were used to characterize the performance of the fiber membrane: scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), tensile testing, water contact angle (WCA) measurements, degradation pH assessment, and topological structure stability tests. We explored the biocompatibility, cytotoxicity, and the influence of the PLA@SF aligned porous composite fiber membrane on the growth behavior of peripheral nerve cells. Results from physical and chemical tests indicate that the PLA@SF composite fiber membrane exhibits an appropriate degradation rate, favorable mechanical and hydrophilic properties, and excellent topological structure stability. MTT assays demonstrate that the PLA@SF composite fiber membrane possesses good biological safety. Furthermore, the synergistic effect of the porous nanostructures and SF improved growth behavior of RSC96 cells: proliferation and migration.
Keywords: Polylactic Acid, silk fibroin, Electrospun fiber membranen, nanotopography, Nerve Regeneration
Received: 04 Feb 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Feng, Liu, Lv, Shao, Niu and Mi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Midaguo Mi, Nantong Hospital of Traditional Chinese Medicine, Nantong, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.