ORIGINAL RESEARCH article
Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Volume 12 - 2025 | doi: 10.3389/fmats.2025.1668454
A Multifunctional Cryogel for Enhanced Angiogenesis and Osteogenesis in Bone Tissue Engineering
Provisionally accepted
- 1Jiangxi Provincial People's Hospital, Nanchang, China
- 2Institute of Metal Research Chinese Academy of Sciences, Shenyang, China
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Bone defects exceeding self-repair capacity remain a major clinical challenge, necessitating biomaterial-based strategies for effective regeneration. This study developed a multifunctional cryogel integrating copper-containing mesoporous bioactive glass (Cu-MBG) and bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) into a decellularized extracellular matrix (dECM). The cryogel’s physicochemical properties, including structure, morphology, porosity, degradation, and mechanical strength, were characterized, confirming its suitability for bone tissue engineering. In vitro studies demonstrated that Cu-MBG/Exos@dECM enhanced osteogenic differentiation and promoted angiogenesis by releasing bioactive copper ions from Cu-MBG and regulating cell proliferation and differentiation via BMSC-Exos. Additionally, the cryogel provided a biomimetic microenvironment supporting cell adhesion and extracellular matrix remodeling, synergistically promoting bone regeneration. These findings highlight Cu-MBG/Exos@dECM as a promising biomaterial for bone repair, offering an effective and advanced strategy for treating bone defects.
Keywords: Mesoporous bioactive glass, decellularized extracellular matrix, Copper ions, Exosomes, Angiogenesis, Osteogenesis
Received: 18 Jul 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Su, Yang, Zeng and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xieping Dong, 13576030901@163.com
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