Frontiers in Molecular Biosciences

Original Research

Published on 14 Jul 2025

Untargeted plasma metabolite detection in sudden sensorineural hearing loss: identifying key metabolic signatures

Rongyue Ma
Huangruici Zhang
Weijie Wang
Changping Yu
Guohang Xiong
Qing Li
Yan Wang
Li Zhou
Yu Zhang
Min Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1567064

2,415 views

Original Research

Published on 14 Jul 2025

Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation

Medhat Taha
Ahmed Alzahrani
Omer Abdelbagi
Rehab M. Bagadood
Naeem F. Qusty
Rami Obaid
Mohammad El-Nablaway
Tourki A. S. Baokbah

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1621240

2,076 views
2 citations

Editorial

Published on 14 Jul 2025

Editorial: Ironome: a still untapped frontier

Gloria C. Ferreira
Vladimir N. Uversky
Zoubida Karim

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1651154

2,369 views

Original Research

Published on 11 Jul 2025

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

Yinghao Zhou
Chenchen Chen
Yibo Meng
Jianchao Ge
Shengkui Meng
Xillong Wang
Yaozong Xu
Guowei Shi
Wandong Yu
Xuetao Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646331

2,233 views

Original Research

Published on 11 Jul 2025

Integrating multi-dimensional data to reveal the mechanisms and molecular targets of baikening granules for treatment of pediatric influenza

Zhaoyuan Gong
Qianzi Che
Mingzhi Hu
Tian Song
Lin Chen
Haili Zhang
Ning Liang
Huizhen Li
Guozhen Zhao
Lijiao Yan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1637980

3,382 views

Original Research

Published on 11 Jul 2025

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

Changying Jing
Yaqi Sun
Hongsheng Bi
Junguo Guo
Cong Ren
Jike Song
Beibei Wang
Qingmei Tian
Dadong Guo
Pengjuan He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1632027

2,701 views

Original Research

Published on 11 Jul 2025

Plasma longitudinal metabolic changes with acute maximal aerobic exercise and one-hour recovery

William A. Fountain
Stefano Donega
Nirad Banskota
Ruin Moaddel
Mona Patel
Linda Zukley
Sarah Church
Katie Bustin
Josephine M. Egan
Jeremy Walston

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1613238

2,507 views
1 citation

Original Research

Published on 11 Jul 2025

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

Xiaodong Shao
Shaolei Guo
Jia Yang
Junjie Dai
Kaihua Cao
Xia Cai
Tianshi Song
Shun Yao
Umar Raza
Kun Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640038

2,362 views

Review

Published on 11 Jul 2025

Review of research progress in sepsis-associated acute kidney injury

Wanning Nian
Weichen Tao
Haiyi Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1603392

5,977 views
3 citations

Original Research

Published on 10 Jul 2025

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

Yucong Zhang
Yuchen Song
Juan Liu
Ming Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616271

1,939 views
1 citation

Review

Published on 10 Jul 2025

Subtle concentration changes in zinc hold the key to fibrillation of α-synuclein: an updated insight on the micronutrient’s role in prevention of neurodegenerative disorders

Samudra Prosad Banik
Debasis Bagchi
Pradipta Banerjee
Sanjoy Chakraborty
Manashi Bagchi
Chaitali Bose
Debasmita De
Sreemoyee Saha
Sudipta Chakraborty

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1603364

4,330 views
2 citations

Original Research

Published on 10 Jul 2025

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer

Xuyan Lan
Xiaoyu Sun
Ruiqi Chen
Lihuan Zhu
Xiaojie Pan
Tianxing Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1619139

1,962 views

Original Research

Published on 10 Jul 2025

Structural bioinformatics and gene expression analysis of maturase K from Lavandula angustifolia (lavender)

Dafeng Liu
Na Li
Daoqi Song
Zhenming Lv

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1628118

1,880 views
2 citations

Review

Published on 09 Jul 2025

Functional metabolomics: unlocking the role of small molecular metabolites

Hetao Chen
Jiao Kong
Peipei Du
Qian Wang
Tao Jiang
Xixi Hou
Tingting Feng
Jiajia Duan
Chuanxin Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542100

3,247 views
3 citations

Original Research

Published on 09 Jul 2025

A comprehensive characterization of metabolic signatures—hypoxia, glycolysis, and lactylation—in non-healing diabetic foot ulcers

Bo Hu
Xuan Li
Yunfeng Li
Shengnan Chai
Mei Jin
Long Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1593390

4,869 views
5 citations

Editorial

Published on 09 Jul 2025

Editorial: Molecular chaperones and polyamines in disease

Stanley Makumire
Graham Chakafana
Xolani H. Makhoba

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1658176

1,180 views

Original Research

Published on 09 Jul 2025

Raider of the lost N-glycans – Localizing rare and frequently overlooked IgG N-glycans with sulfation or bisecting LacNAc

Robert Burock
Léa Chuzel
Thilo Kähne
Udo Reichl
Erdmann Rapp
René Hennig

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1593708

3,835 views
1 citation

Original Research

Published on 08 Jul 2025

Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics

Ji-Peng Liu
Long-Teng Tu
Ke-Zhen Yang
Yin-Yin Li
Yu Gong
Bing-Xuan Han
Chuan Liu
Tian-Qi Xia
Yu Liu
Xiao-Min Hao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1619356

2,709 views

Original Research

Published on 07 Jul 2025

Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction

Daniyaer Nuerdebieke
Lizhong Yao
Lange Guo
Jiuzhi Li
Hongliang Jia
Yukui Nan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1596534

1,652 views

Original Research

Published on 07 Jul 2025

Sustainable synthesis of zinc oxide nanoparticles from Persicaria lapathifolia: versatile anticancer and antibacterial applications

Essam Nageh Sholkamy
Mohamed A. A. Abdelhamid
Hadjer Rebai
Ananth Sivapunniyam
Mi-Ran Ki
Seung Pil Pack
Hazim O. Khalifa

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1601811

2,432 views
2 citations

Original Research

Published on 04 Jul 2025

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

Yufan Sheng
Sen Niu
Da Li
Chunyuan Meng
Tong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605117

2,311 views
1 citation

Original Research

Published on 03 Jul 2025

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

Xue-Fei Wei
Feng Zhang
Han-Xu Zhu
Zhe-Zhe Tian
Miao-Miao Xu
Yu-Chen Fan
Kai Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614311

2,272 views

Hypothesis and Theory

Published on 02 Jul 2025

Dinucleotide codon substitutions as a signature of diversifying selection in Mycobacterium tuberculosis

Danila Zimenkov
Anastasia Ushtanit

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1511372

2,587 views

Original Research

Published on 01 Jul 2025

Clinicopathologic and proteomic characteristics of low-grade undifferentiated spindle cell sarcoma

Yani Wei
Hongjun Li
Shujin He
Min Li
Yongyu Chen
Huijuan Shi
Anjia Han

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1591644

2,367 views

5,872 Publications

volumes

Volume 12 - 2025

Untargeted plasma metabolite detection in sudden sensorineural hearing loss: identifying key metabolic signatures

Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation

Editorial: Ironome: a still untapped frontier

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

Integrating multi-dimensional data to reveal the mechanisms and molecular targets of baikening granules for treatment of pediatric influenza

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

Plasma longitudinal metabolic changes with acute maximal aerobic exercise and one-hour recovery

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

Review of research progress in sepsis-associated acute kidney injury

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

Subtle concentration changes in zinc hold the key to fibrillation of α-synuclein: an updated insight on the micronutrient’s role in prevention of neurodegenerative disorders

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer

Structural bioinformatics and gene expression analysis of maturase K from Lavandula angustifolia (lavender)

Functional metabolomics: unlocking the role of small molecular metabolites

A comprehensive characterization of metabolic signatures—hypoxia, glycolysis, and lactylation—in non-healing diabetic foot ulcers

Editorial: Molecular chaperones and polyamines in disease

Raider of the lost N-glycans – Localizing rare and frequently overlooked IgG N-glycans with sulfation or bisecting LacNAc

Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics

Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction

Sustainable synthesis of zinc oxide nanoparticles from Persicaria lapathifolia: versatile anticancer and antibacterial applications

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

Dinucleotide codon substitutions as a signature of diversifying selection in Mycobacterium tuberculosis

Clinicopathologic and proteomic characteristics of low-grade undifferentiated spindle cell sarcoma