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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1389896
This article is part of the Research Topic Diet, Trace Elements, and Gut Microbiota in Bone and Cartilage Diseases View all 3 articles

Genetic Insights into Dietary Patterns, Liposome Mediation, and Osteoporosis Risk: A Mendelian Randomization Study

Provisionally accepted
Kehan Long Kehan Long 1Tengfei Zheng Tengfei Zheng 2*Ao Gong Ao Gong 3Zhendong Ying Zhendong Ying 3*Lei Zhang Lei Zhang 4*
  • 1 Shandong Second Medical University, Weifang, China
  • 2 Shandong First Medical University, Tai'an, Shandong, China
  • 3 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
  • 4 The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Background: This study examines the indirect causal relationships between dietary habits and osteoporosis, mediated through liposomes, utilizing a two-sample Mendelian Randomization (MR) approach. The research leverages genetic variations as instrumental variables to explore the genetic influences on dietary habits, liposomes, and osteoporosis, aiming to unravel the complex interplay between diet, lipid metabolism, and bone health.The study utilized genome-wide association studies (GWAS) data for liposomes from Finnish individuals and osteoporosis-related data, alongside dietary factors from the OpenGWAS database. Instrumental variables were selected based on genetic variants associated with these factors, using a strict significance level and linkage disequilibrium threshold. Statistical analysis employed the Inverse Variance Weighted method, weighted median, and mode-based methods within the R environment, complemented by sensitivity analyses to ensure the robustness of the causal inferences.Results: Findings revealed significant causal relationships between specific dietary components (white rice, cereal, and non-oily fish) and osteoporosis risk, both directly and mediated through Genetic Insights into Dietary Patterns and Osteoporosis: Unveiling Liposome's Mediating Function 删除[longgggg]:changes in liposome levels. Notably, white rice consumption was associated with an increased risk of osteoporosis, while cereal and non-oily fish intake showed protective effects. Further, certain liposomes were identified as mediators in these relationships, suggesting a link between diet, lipid profiles, and bone health.The study highlights the significant impact of dietary habits on osteoporosis risk, mediated through liposomes. These findings underscore the importance of considering lipidomic profiles in dietary guidance and suggest potential targets for preventing osteoporosis through nutritional interventions.

    Keywords: Osteoporosis, dietary habits, Liposomes, Mendelian randomization, GWAS, causal inference

    Received: 22 Feb 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Long, Zheng, Gong, Ying and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tengfei Zheng, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Zhendong Ying, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
    Lei Zhang, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.