ORIGINAL RESEARCH article
Front. Nutr.
Sec. Food Chemistry
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1603237
This article is part of the Research TopicFood-derived Plant Polysaccharides: Composition, Bioavailability and Health-promoting PropertiesView all articles
Effects of in vitro simulated digestion on the α-glucosidase inhibitory activity, structure, and prebiotic activity of a polysaccharide from Anemarrhena asphodeloides Bunge
Provisionally accepted
- 1Hainan Medical University, Haikou, China
- 2South China University of Technology, Guangzhou, Guangdong Province, China
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This study explored the changes in the structure and α-glucosidase inhibitory activity of a nonstarch polysaccharide derived from Anemarrhena asphodeloides Bunge, AABP-1B, during digestion in vitro and its effect on host intestinal microbiota. Simulations of digestion in the upper digestive tract showed that the reducing sugar content and molecular weight of AABP-1B changed slightly, though no monosaccharides were detected. AABP-1B was resistant to degradation in the simulated upper gastrointestinal environments, retained strong α-glucosidase inhibitory activity after digestion, which may be related to the lack of structural changes. In in vitro fermentation, AABP-1B enhanced the growth of commensal microorganisms, including Bacteroides, Megasphaera, and Prevotella, while inhibiting the proliferation of pathogenic bacteria, such as Escherichia-Shigella. Fermentation of AABP-1B by gut microbes resulted in a notable increase in short-chain fatty acid contents and a decrease in pH levels. Our findings showed that AABP-1B promotes intestinal health and may serve as a prebiotic in the development of functional food.
Keywords: Anemarrhena asphodeloides Bunge Polysaccharide, α-glucosidase, Digestive property, Structure, intestinal microbiota
Received: 31 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Li, Fang, Lan, Xiao, Zhang, Li, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bing Li, South China University of Technology, Guangzhou, 510 641, Guangdong Province, China
Juncheng Chen, Hainan Medical University, Haikou, China
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