Frontiers in Pain Research | Neuromodulatory Interventions

Original Research

Published on 02 Feb 2026

Long-term efficacy of neuromodulation in chronic pain management: a single-center retrospective study

in Neuromodulatory Interventions

Filip Blazek
David Krahulik
Lumir Hrabalek
Martin Gabrys

Frontiers in Pain Research

doi 10.3389/fpain.2026.1737302

384 views

Original Research

Accepted on 29 Jan 2026

Determinants of Adherence and Safety in Fully Autonomous Home-Based Transcranial Direct Current Stimulation for Fibromyalgia

in Neuromodulatory Interventions

WOLNEI CAUMO
Lucas Bohrer Flores
Isabela Souza Fontoura
Graziele Borges Bueno
Paulo Sanches
Danton Pereira Da Silva JUnior
Iraci Lucena da Silva Torres
Felipe Fregni

Frontiers in Pain Research

Review

Published on 29 Jan 2026

The role of transcutaneous auricular vagus nerve stimulation in chronic pain: from neurobiological mechanisms to clinical applications

in Neuromodulatory Interventions

Jing Zhang
Yang Zhang
Jingxue Zhao
Jifei Sun
Xiaoxu Zhang

Frontiers in Pain Research

doi 10.3389/fpain.2026.1733445

648 views

Case Report

Accepted on 26 Jan 2026

Ultrasound-guided dual-target low-temperature plasma ablation for refractory cervicogenic orofacial pain: a report of two cases

in Neuromodulatory Interventions

Juan Liu
Jianxun Li
Yifan Wang
Xianting Chen
Baishan Wu

Frontiers in Pain Research

103 views

Hypothesis and Theory

Accepted on 22 Jan 2026

Variational Free Energy as a Conceptual Framework for Understanding Habituation in Spinal Cord Stimulation

in Neuromodulatory Interventions

Alexander S Taghva

Frontiers in Pain Research

135 views

Case Report

Published on 20 Jan 2026

Treating chronic pain with low dose ketamine and adjunct therapies within a biopsychosocial approach: a case series

in Neuromodulatory Interventions

Shahar Almog
Michelle Weiner
Jessica N. Howarth
Jenelle Becerra
Jacobo D. Fux
Meredith S. Berry

Frontiers in Pain Research

doi 10.3389/fpain.2025.1675821

682 views

Original Research

Published on 13 Nov 2025

A forgotten frontier: spinal cord stimulation for iatrogenic and traumatic peripheral neuropathic pain

in Neuromodulatory Interventions

Linda Kollenburg
Hisse Arnts
Inge Arnts
Robert van Dongen
Heinrich Moser
Frank van Haren
Mark van Ooijen
Robert Jason Yong
Christopher L. Robinson
Erkan Kurt

Frontiers in Pain Research

doi 10.3389/fpain.2025.1661520

1,334 views

Original Research

Published on 13 Oct 2025

Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice

in Neuromodulatory Interventions

Sara Marinelli
Claudia Rossi
Luisa Pieroni
Giacomo Giacovazzo
Valentina Vacca
Federica De Angelis
Ilaria Cicalini
Valentina Mastrorilli
Chiara Parisi
Zuleyha Nihan Yurtsever

Frontiers in Pain Research

doi 10.3389/fpain.2025.1655712

1,729 views

Brief Research Report

Published on 29 Sep 2025

Primary somatosensory cortex oscillations in trigeminal neuralgia: laser-evoked signatures and their potential relevance to microvascular decompression

in Neuromodulatory Interventions

Britta N. Kretzschmar
André Rupp
Sandro M. Krieg
Rezvan Ahmadi

Frontiers in Pain Research

doi 10.3389/fpain.2025.1652354

1,435 views

Editorial

Published on 10 Sep 2025

Editorial: Non-invasive therapy for pain relief

in Neuromodulatory Interventions

Michael D. Staudt
Nader Pouratian
Jan Kubanek
Julie G. Pilitsis

Frontiers in Pain Research

doi 10.3389/fpain.2025.1690467

1,674 views

General Commentary

Published on 02 Sep 2025

Commentary: The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy

in Neuromodulatory Interventions

Giuseppe Marineo

Frontiers in Pain Research

doi 10.3389/fpain.2025.1677861

1,067 views

Systematic Review

Published on 01 Aug 2025

Clinical, neurophysiological and neurochemical effects of non-invasive electrical brain stimulation in fibromyalgia syndrome—a systematic review and meta-analysis

in Neuromodulatory Interventions

Christine Winterholler
Maria Helena Coura
Pedro Montoya

Frontiers in Pain Research

doi 10.3389/fpain.2025.1593746

3,213 views
1 citation

Review

Published on 28 Jul 2025

A comprehensive review of the supraspinal mechanisms of spinal cord stimulation on chronic pain and cognition

in Neuromodulatory Interventions

Kelly E. Gartner
Sofia Rustioni
Aamya Vohra
Mustafa Almosawi
Norah Hill
Travis Stewart
Nelleke C. van Wouwe
Ajmal Zemmar

Frontiers in Pain Research

doi 10.3389/fpain.2025.1589723

3,073 views
4 citations

Systematic Review

Published on 22 Jul 2025

The effectiveness of spinal cord stimulation combined with physiotherapy in the management of chronic pain in adults: a systematic review

in Neuromodulatory Interventions

Adilia Maria Soares Porciuncula Barros
Gabrielly Santos Pereira
Josie Resende Torres da Silva
Marcelo Lourenço da Silva
Maria do Desterro da Costa e Silva
Luciano Maia Alves Ferrera

Frontiers in Pain Research

doi 10.3389/fpain.2025.1620289

3,392 views

Mini Review

Published on 07 Jul 2025

The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy

in Neuromodulatory Interventions

Hassan Aboumerhi
Henry Vucetic
Andrew Gruenzel
Bahar Moftakhar
Mona Gupta
Santosh K. Rao
Michael D. Staudt

Frontiers in Pain Research

doi 10.3389/fpain.2025.1607102

5,621 views
1 citation

Brief Research Report

Published on 25 Jun 2025

Repetitive transcranial magnetic stimulation at low frequency for the treatment of fibromyalgia. Results from the first treatment cohort at the brainwave clinic

in Neuromodulatory Interventions

Elliot Nation
Anushka Irani
Stephanie Barrett

Frontiers in Pain Research

doi 10.3389/fpain.2025.1558175

5,190 views

Systematic Review

Published on 17 Jun 2025

Low-intensity focused ultrasound of the spine in the treatment of chronic pain and movement disorder: a scoping review

in Neuromodulatory Interventions

Kyung Seol
Brian Hong
Nicolas Kelhofer
Suguna Pappu
Michael Oelze

Frontiers in Pain Research

doi 10.3389/fpain.2025.1606672

4,539 views
1 citation

Original Research

Published on 16 Jun 2025

Modulation of pain sensitivity by tDCS using different anodal connector locations: a single-blinded, randomized, sham-controlled study

in Neuromodulatory Interventions

Shang-Yueh Tsai
Yi-Ru Lin
David M. Niddam

Frontiers in Pain Research

doi 10.3389/fpain.2025.1533962

1,713 views

Case Report

Published on 10 Jun 2025

Case Report: Lateral C1–C2 puncture for intrathecal baclofen therapy: an alternative effective and safe approach after spinal cord injury

in Neuromodulatory Interventions

Rayan Fawaz
Hayat Belaid
Baptiste Eklu
Jean Baptiste Thiebaut
Manon Duraffourg

Frontiers in Pain Research

doi 10.3389/fpain.2025.1571716

1,647 views

Clinical Trial

Published on 15 Apr 2025

Effects on perceived pain and somatosensory function after transcutaneous neuromodulation in patients with chronic low back pain: a quasi-experimental study with a crossover intervention

in Neuromodulatory Interventions

Francisco Selva-Sarzo
Eleuterio A. Sánchez Romero
Juan Nicolás Cuenca-Zaldívar
Beatriz García-Haba
Claudio Akiyama
Rob Sillevis
Samuel Fernández-Carnero

Frontiers in Pain Research

doi 10.3389/fpain.2025.1525964

3,498 views
5 citations

Original Research

Published on 09 Apr 2025

Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain

in Neuromodulatory Interventions

Changfang Zhu
Ki-Soo Jeong
Muhammad Edhi
Victoria Rogness
Carl Y. Saab
Rosana Esteller

Frontiers in Pain Research

doi 10.3389/fpain.2025.1541078

2,271 views

Opinion

Published on 17 Feb 2025

Pain and the autonomic nervous system. The role of non-invasive neuromodulation with NESA microcurrents

in Neuromodulatory Interventions

Nelson Azevedo
Raquel Medina-Ramírez

Frontiers in Pain Research

doi 10.3389/fpain.2025.1410808

7,873 views
3 citations

Original Research

Published on 11 Nov 2024

Functional outcomes and healthcare utilization trends in postsurgical and nonsurgical patients following high-frequency (10 kHz) spinal cord stimulation therapy

in Neuromodulatory Interventions

Vinicius Tieppo Francio
Logan Leavitt
John Alm
Daniel Mok
Byung-Jo Victor Yoon
Niaman Nazir
Christopher M. Lam
Usman Latif
Timothy Sowder
Edward Braun

Frontiers in Pain Research

doi 10.3389/fpain.2024.1451284

2,393 views
1 citation

Editorial

Published on 15 May 2024

Editorial: Non-invasive and minimally invasive vagus nerve stimulation for chronic pain

in Neuromodulatory Interventions

Anna Woodbury
Peter Staats

Frontiers in Pain Research

doi 10.3389/fpain.2024.1402918

4,482 views
4 citations

57 articles

articles

Long-term efficacy of neuromodulation in chronic pain management: a single-center retrospective study

Determinants of Adherence and Safety in Fully Autonomous Home-Based Transcranial Direct Current Stimulation for Fibromyalgia

The role of transcutaneous auricular vagus nerve stimulation in chronic pain: from neurobiological mechanisms to clinical applications

Ultrasound-guided dual-target low-temperature plasma ablation for refractory cervicogenic orofacial pain: a report of two cases

Variational Free Energy as a Conceptual Framework for Understanding Habituation in Spinal Cord Stimulation

Treating chronic pain with low dose ketamine and adjunct therapies within a biopsychosocial approach: a case series

A forgotten frontier: spinal cord stimulation for iatrogenic and traumatic peripheral neuropathic pain

Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice

Primary somatosensory cortex oscillations in trigeminal neuralgia: laser-evoked signatures and their potential relevance to microvascular decompression

Editorial: Non-invasive therapy for pain relief

Commentary: The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy

Clinical, neurophysiological and neurochemical effects of non-invasive electrical brain stimulation in fibromyalgia syndrome—a systematic review and meta-analysis

A comprehensive review of the supraspinal mechanisms of spinal cord stimulation on chronic pain and cognition

The effectiveness of spinal cord stimulation combined with physiotherapy in the management of chronic pain in adults: a systematic review

The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy

Repetitive transcranial magnetic stimulation at low frequency for the treatment of fibromyalgia. Results from the first treatment cohort at the brainwave clinic

Low-intensity focused ultrasound of the spine in the treatment of chronic pain and movement disorder: a scoping review

Modulation of pain sensitivity by tDCS using different anodal connector locations: a single-blinded, randomized, sham-controlled study

Case Report: Lateral C1–C2 puncture for intrathecal baclofen therapy: an alternative effective and safe approach after spinal cord injury

Effects on perceived pain and somatosensory function after transcutaneous neuromodulation in patients with chronic low back pain: a quasi-experimental study with a crossover intervention

Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain

Pain and the autonomic nervous system. The role of non-invasive neuromodulation with NESA microcurrents

Functional outcomes and healthcare utilization trends in postsurgical and nonsurgical patients following high-frequency (10 kHz) spinal cord stimulation therapy

Editorial: Non-invasive and minimally invasive vagus nerve stimulation for chronic pain