Frontiers in Pharmacology | Drug Metabolism and Transport

Review

Published on 14 May 2025

Nanocarrier-based targeted drug delivery for Alzheimer’s disease: addressing neuroinflammation and enhancing clinical translation

in Drug Metabolism and Transport

Kang Wang
Rongying Yang
Jing Li
Haitao Wang
Li Wan
Jiale He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591438

926 views

Review

Published on 12 May 2025

Global research on the utilization of population pharmacokinetic model: a bibliometric analysis from 2000 to 2024

in Drug Metabolism and Transport

Yucheng Yao
Liyuan Zhang
Dan Chen
Shiran Qin
Mingyu Meng
Qiuyan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548023

621 views

Original Research

Published on 12 May 2025

Development and application of a UHPLC-MS/MS method for the simultaneous determination of firmonertinib and its main metabolite AST-5902 in rat plasma: a study on the in vivo drug interaction between firmonertinib and paxlovid

in Drug Metabolism and Transport

Peng-Fei Tang
Su-Su Bao
Wei-Fei Xie
Zhong-Xiang Xiao
Xue-Meng Wu
Hong-Lei Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570206

478 views

Brief Research Report

Published on 12 May 2025

Osmotic laxatives do not alter dabigatran plasma concentration in healthy volunteers – a randomized, controlled, cross-over trial

in Drug Metabolism and Transport

Matthias Weiss-Tessbach
Al Medina Dizdarevic
Alexander Kupis
Thorsten Bischof
Christa Firbas
Peter Quehenberger
Ulla Derhaschnig
Max Frimmel
Bernd Jilma
Christian Schoergenhofer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579014

429 views

Clinical Trial

Published on 12 May 2025

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers

in Drug Metabolism and Transport

Yike Wang
Dai Li
Tong Zhang
Sumei Xu
Yanxin Zhang
Kaijing Zhao
Shaorong Li
Kai Shen
Xiaomin Li
Pingsheng Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563556

583 views

Original Research

Published on 02 May 2025

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

in Drug Metabolism and Transport

Peile Wang
Jingli Lu
Jing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578643

1,029 views

Original Research

Published on 30 Apr 2025

Molecular pharmacokinetic mechanism of JBP485 against aristolochic acid I (AAI) -induced nephrotoxicity

in Drug Metabolism and Transport

Chong Wang
Huan Jin
Changyuan Wang
Jingjing Wu
Qiang Meng
Ming Zhong
Huijun Sun
Yuheng Wei
Ge Gao
Taiichi Kaku

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577942

845 views

Original Research

Published on 29 Apr 2025

Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study

in Drug Metabolism and Transport

Fei Wang
Ze Li
Youqi Huang
Qin Liu
Libin Zhao
Honghong Wang
Hongjin Gao
Mingyu Chen
Yuze Lin
Xingang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574949

876 views

Original Research

Published on 29 Apr 2025

Impact of CYP3A4 functional variability on ziprasidone metabolism

in Drug Metabolism and Transport

Qi Zhou
Yameng Wu
Zhize Ye
Zheyan Zhang
Kai Zheng
Jianchang Qian
Zhongxiang Xiao
Yang Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585040

611 views

Original Research

Published on 28 Apr 2025

Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging

in Drug Metabolism and Transport

Marco Iannone
Marcelo Kravicz
Paolo Rainone
Antonia I. Antoniou
Stefano Stucchi
Silvia Valtorta
Arianna Amenta
Elia Anna Turolla
Sara Pellegrino
Daniele Passarella

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566257

996 views

Original Research

Published on 28 Apr 2025

Prediction of pharmacokinetic/pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model

in Drug Metabolism and Transport

Mengjun Zhang
Keheng Wu
Sihui Long
Xiong Jin
Bo Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578117

1,079 views

Original Research

Published on 25 Apr 2025

A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance

in Drug Metabolism and Transport

Liming Xie
Guanfeng Chen
Qianqian Ouyang
Weiyan Quan
Xiaoming Xie
Xiaoling Chen
Lefan Li
Sidong Li
Rizhi Chen
Rongqiong Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579771

638 views

Original Research

Published on 24 Apr 2025

Hydroxychloroquine increases the exposure of methotrexate in plasma and red blood cells: a pharmacokinetic interaction study in rats in vivo

in Drug Metabolism and Transport

Guijie Zhang
Rui Wang
Geping Chen
Simin Liu
Hongyu Jie
Wenying Chen
Qiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561001

751 views

Clinical Trial

Published on 23 Apr 2025

Pharmacokinetics and bioequivalence assessment of two prucalopride formulations in healthy Chinese women: a randomized, open-label, two-period, two-sequence, self-crossover study

in Drug Metabolism and Transport

Xiangxin Huang
Ying Wang
Bei Li
Xiaoqun Shen
Xuexia Tao
Wenwen Zheng
Qi Luo
Lei Xiong
Lin Wang
Shufan Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562692

614 views

Clinical Trial

Published on 17 Apr 2025

The pharmacokinetics and Concentration-QTc analysis of a new etomidate analog ET-26-HCl: a phase I trial in healthy Chinese subjects

in Drug Metabolism and Transport

Kun He
Wenyu Zhang
Xiangran Kong
Lize Li
Lei Diao
Qing Wen
Guohai Su
Xiaoran Yang
Hongyan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534717

826 views

Original Research

Published on 16 Apr 2025

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein

in Drug Metabolism and Transport

Gang Zhao
Yajuan Li
Mengyuan Liu
Wei Chang
Hui Shen
Junhui Xue
Fengzhou Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564174

753 views