Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Accepted on 21 Oct 2025

Low-Dose Methotrexate Adverse Reaction Risk in Renal Impairment: Pharmacovigilance and Physiological Pharmacokinetic Model Assessment

in Drug Metabolism and Transport

Lichang Zhang
Jianling Li
Xin Wang
Yaolei Zhang
Sen Gao
Deshi Dong
Yanna Zhu
Shilei Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703557

Clinical Trial

Accepted on 20 Oct 2025

Population pharmacokinetics/pharmacodynamics and safety of YPEG-rhGH in elderly subjects

in Drug Metabolism and Transport

Yajie He
Xin Zeng
Qianfeng Yang
Qiuyun You
Xuejia Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651323

Original Research

Published on 17 Oct 2025

QSAR-based physiologically based pharmacokinetic (PBPK) modeling for 34 fentanyl analogs: model validation, human pharmacokinetic prediction and abuse risk insights

in Drug Metabolism and Transport

Simeng Zhang
Yawen Xu
Xianbin Zeng
Jingzhi Ran
Yuanyuan Chen
Lixin Kuai
Kaixi Li
Peng Xu
Fang Yan
Dan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692293

866 views

Clinical Trial

Published on 16 Oct 2025

Comparative study of the pharmacokinetics, efficacy and safety of ET-26 in elderly and non-elderly subjects: the results of a phase I clinical trial

in Drug Metabolism and Transport

Fan Yang
Jing Sun
Pan-Pan Ye
Wen-Shuo Lv
Li-Ze Li
Bao-Zhong Zhao
John Van Den Anker
Yi Zheng
Bo-Wen Ke
Xiao-Ran Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665322

248 views

Methods

Accepted on 14 Oct 2025

Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency

in Drug Metabolism and Transport

Mladen Vassilev Tzvetkov
Vincent Rönnpagel
Felix Morof
Giuliano Ciarimboli
Markus Grube
Marleen J Meyer- Tönnies

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629421

102 views

Review

Published on 13 Oct 2025

The impact of the exposome on cytochrome P450-mediated drug metabolism

in Drug Metabolism and Transport

Hwaida Ali
Mireille M. Hanna
Noha Alziny
Shuaib Mahmoud
Abdallah Borham
Aya Mustafa
Anwar Abdelnaser

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639646

1,000 views

Clinical Trial

Published on 08 Oct 2025

A phase I study of HEC73543, an oral FLT3 inhibitor: the effect of food on pharmacokinetics after oral dosing in healthy Chinese volunteers

in Drug Metabolism and Transport

Di Wang
Min Wu
Xiaojiao Li
Yingzhi Jiang
Bing Liu
YingJun Zhang
Li Deng
Yanhua Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636504

1,578 views

Review

Accepted on 07 Oct 2025

Strategy Advancements in Placental Pharmacokinetics: From In Vitro Experiments to In Silico Prediction

in Drug Metabolism and Transport

Zhimin Li
Yue Wu
Siyu Zeng
Fei Wang
JIAO ZHANG
Shiran Li
Yong Yang
Yujie Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694886

143 views

Editorial

Published on 06 Oct 2025

Editorial: Diverse functions of drug transporters

in Drug Metabolism and Transport

Jeffry C. Granados
Kit Wun Kathy Cheung
Bhagwat Prasad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697775

621 views

Original Research

Published on 30 Sep 2025

Characterization of trazodone metabolic pathways and species-specific profiles

in Drug Metabolism and Transport

Vanessa Petrucci
Patrizia Dragone
Marcello C. Laurenti
Laura Oggianu
Volha Zabela
Agnese Cattaneo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636919

1,404 views

Original Research

Published on 30 Sep 2025

Study on cerebrospinal fluid meropenem, vancomycin and tigecycline monitoring in patients with central nervous system infection following neurosurgery under different drug regimens

in Drug Metabolism and Transport

Xiaoman Zhao
Yanan Qiao
Qing Xie
Zheng Zhang
Yan Song
Jianbang Kang
Jinchuan Li
Jinju Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666168

1,801 views

Original Research

Accepted on 29 Sep 2025

1H-NMR-based metabolomics study of Rifafour in a healthy Kramnik (C3HeB/FeJ) tuberculosis mouse model

in Drug Metabolism and Transport

Oluwadara Pelumi Omotayo
Siyethemba Bhengu
Yolandy Lemmer
Kobus Venter
Shayne Mason

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661938

388 views

Clinical Trial

Published on 26 Sep 2025

Pharmacokinetics, safety and tolerability of ipatasertib in combination with palbociclib and fulvestrant in patients with advanced breast cancer in a phase Ib study

in Drug Metabolism and Transport

Kit Wun Kathy Cheung
Ksenia Arzumanova
Victor Poon
Adam Harris
Ryan Johnson
Frauke Schimmoller
Rucha Sane

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670582

1,529 views

Original Research

Published on 26 Sep 2025

Pharmacokinetic-pharmacodynamic target attainment analyses as support for meropenem dosing regimens in critically ill adult and elderly patients with Pseudomonas aeruginosa infections

in Drug Metabolism and Transport

Ruyu Tao
Sumyeut Chan
Jinxingyi Wang
Xianhe Wang
Lei Shi
Xue Lan
Ling Chen
Xiaohui Mu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643553

1,932 views

Original Research

Published on 23 Sep 2025

Evaluation the inhibitory effect of nicardipine on the metabolism of quetiapine

in Drug Metabolism and Transport

Jinzhao Yang
Hailun Xia
Qingqing Li
Ruibin Li
Lu Cao
Congrong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567044

2,874 views

Original Research

Published on 19 Sep 2025

Stability study of common vasoactive drugs diluted in five types of solutions

in Drug Metabolism and Transport

Han Yang
Bingbing Xiang
Deiying Gong
Guoyan Zhao
Wensheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670183

1,779 views