Frontiers in Pharmacology | Neuropharmacology

Original Research

Accepted on 10 Apr 2026

Lycium barbarum glycopeptide Confers Neuroprotection in Chronic Ocular Hypertensive Rats: A Study Investigating Visual Function, Retinal Structure, Microcirculation, and Pyroptosis

in Neuropharmacology

Chunlin Zhao
Wei Shi
Xuejing Lu

Frontiers in Pharmacology

Original Research

Published on 10 Apr 2026

Sex-specific behavioral and monoaminergic network alterations following adolescent binge-like ethanol and WIN55,212-2 exposure under chronic nicotine in rats

in Neuropharmacology

Philippe De Deurwaerdère
Katie Haywood
Norbert Abela
Maurizio Casarrubea
Giuseppe Di Giovanni

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1798364

Review

Published on 09 Apr 2026

Flavonoids improve neurotransmitters for Parkinson’s treatment: mechanism and therapeutic potential

in Neuropharmacology

Yue Zhang
Yifan Bu
Mingrong Song
Zhihua Hao
Jing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1799142

100 views

Correction

Accepted on 08 Apr 2026

Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation

in Neuropharmacology

Jiping Li
Xinping Dai
Liuyi Zhou
Xinxiu Li
Dongxiao Pan

Frontiers in Pharmacology

Original Research

Accepted on 08 Apr 2026

Impact of Valproate Co-medication and Age on Lurasidone Exposure: A Population Pharmacokinetic Study and Real-World Evaluation in Chinese Psychiatric Inpatients

in Neuropharmacology

Ye Yang
Haoyang Lu
Tao Xiao
Xiaojia Ni
Zhanzhang Wang
Yuqing Chen
Lijing Dai
Emei Song
Fanghua Su
Yuguan Wen

Frontiers in Pharmacology

Original Research

Accepted on 07 Apr 2026

Anxiolytic and Cognitive Effects of Dietary Phenolics in Zebrafish: Rosmarinic Acid, Gallic Acid, and 3-Hydroxytyrosol

in Neuropharmacology

ILKAY ERDOGAN ORHAN
TUGBA UCAR AKYUREK
Fatma Sezer Senol Deniz
Ion Brinza
Ion Brinza
Lucian Hritcu

Frontiers in Pharmacology

Original Research

Accepted on 07 Apr 2026

Unveiling the neuroprotective effects of pomegranate extract and/or physical activity against aluminum chloride-induced Alzheimer's disease in rats: Modulation of multitude pathways

in Neuropharmacology

Ahmed M.E. Hamdan
Hadil Alahdal
Haider F.S. Al-Zubaidy
Karema Abu-Elfotuh
Enji Reda
Yasmin Mahran
Asmahan Alghamdi
Heba Abdelnaser Aboelsoud
Samia A. Ismael
Ehsan Khedre

Frontiers in Pharmacology

Original Research

Accepted on 07 Apr 2026

Employing zebrafish to understand genetic drivers of epilepsy-related comorbid behaviors

in Neuropharmacology

Chinwendu Ononuju
Kharma Hall
Olivia Beatty
Scott C Baraban
Colleen CarpenterSwanson

Frontiers in Pharmacology

Original Research

Published on 07 Apr 2026

Trazodone effectiveness in depression (TED): a comparative evaluation of effect sizes trazodone extended release and SSRIs in the treatment of major depressive disorder

in Neuropharmacology

Dominika Dudek
Adrian Andrzej Chrobak
Karolina Podkowa
Anna Julia Krupa
Aleksandra Gorostowicz
Rafał Jaeschke
Andrzej Juryk
Marcin Siwek

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1739359

269 views

Original Research

Published on 07 Apr 2026

Sex differences in levodopa pharmacokinetics in early Parkinson’s disease: implications on levodopa-related complications

in Neuropharmacology

Valeria Conti
Emanuela De Bellis
Graziamaria Corbi
Bruno Charlier
Viviana Izzo
Maria Claudia Russillo
Marianna Amboni
Marina Picillo
Cesa Lorella Maria Scaglione
Ilaria Cani

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1748932

112 views

Review

Accepted on 06 Apr 2026

An Integrative Neuropharmacological Review of Huntington's Disease Challenges and the Role of Novel Formulations in Addressing Pharmacological–Pharmaceutical Limitations

in Neuropharmacology

Mahmoud Senousy
Aya Hamdy
Mohamed Bakr Zaki
Mai A. Abd Elmawla
Heba R. Ghaiad
Riham El-Shiekh
Sadek Ahmed
Hazim O. Khalifa

Frontiers in Pharmacology

Original Research

Accepted on 06 Apr 2026

Activated glutamatergic neurons in basolateral amygdala suppress nicotine preference behavior in mice

in Neuropharmacology

Naotaka Izuo
Takuma Fujii
Takashi Asano
Yusuke Yano
Naoya Nishitani
Katsuyuki Kaneda
Atsumi Nitta

Frontiers in Pharmacology

Original Research

Accepted on 03 Apr 2026

UNDERSTANDING QUANTITATIVE EFFECTS OF ANTI-AMYLOID THERAPIES ON TAU BIOMARKERS AND FUNCTIONAL OUTCOME. INSIGHTS FROM A COMPREHENSIVE MECHANISTIC QUANTITATIVE SYSTEMS PHARMACOLOGY STUDY

in Neuropharmacology

Hugo Geerts
Shaina M Short
Athena Grant
Silke Bergeler
Piet Van Der Graaf

Frontiers in Pharmacology

Original Research

Published on 02 Apr 2026

Exploring histone acetylation in ischemic stroke: CREBBP and CKAP4 as candidate biomarkers linked to histone acetylation networks

in Neuropharmacology

Yanni Wang
Fan Yang
Jiaojiao Tan
Zhentao Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1727813

173 views

Original Research

Accepted on 01 Apr 2026

Immune profiling in trigeminal neuralgia reveals altered cytokine and chemokine signatures in cerebrospinal fluid and serum

in Neuropharmacology

Hong Liu
Ziwei Liu
Jiang-Tao Zhang
Xuelong Wang
Li-Hua Chen
Xiaohong Jin
Tong Liu
Fuhai Ji

Frontiers in Pharmacology

Original Research

Published on 01 Apr 2026

Akkermansia muciniphila improving depression-like behaviors by regulating glycerophospholipid metabolism in gut-brain axis

in Neuropharmacology

Fei He
Shunjie Bai
Jing Xie
Yongzhi Zhang
Ke Xu
Jiaolin Wang
Yi Ren
Zhe Ren
Jianjun Chen
Ying Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1790866

202 views

Original Research

Accepted on 31 Mar 2026

Investigating the Therapeutic Mechanism of Puerarin in Vascular Dementia: An Integrated Approach Combining Network Pharmacology and Experimental Validation

in Neuropharmacology

Hongmei Tang
Li Yanjiao
Yuting Pu
LINGXUE WANG
Yunfang YANG
Lu LIU
XUE BAI

Frontiers in Pharmacology

Review

Accepted on 31 Mar 2026

Off-label and investigational drugs in the treatment of pathological gambling: A critical review

in Neuropharmacology

Leon Bissig
Jochen Mutschler

Frontiers in Pharmacology

Review

Published on 31 Mar 2026

The immunothrombosis pathway linking pulmonary disease to stroke and neurodegeneration: mechanisms and therapeutic implications

in Neuropharmacology

Aiping Zou
Huimin You
Jian Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1811794

148 views

Original Research

Published on 31 Mar 2026

A machine learning model integrating gut microbiota biomarkers for predicting neurological recovery after cerebral hypoxia-ischemia: a single-center study augmented with public data

in Neuropharmacology

Ling Kong
Chunhua Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1756017

Original Research

Published on 31 Mar 2026

Remimazolam versus propofol for postoperative ICU sedation in mechanically ventilated cancer patients: a noninferiority randomized clinical trial

in Neuropharmacology

Congcong Zhao
Xiaoxuan Fan
Leying Li
Zihan Nan
Xin lin
Yaqi Han
Yanshuo Wu
Yanling Yin
Yan Xin
Zhenjie Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1784928

128 views

Hypothesis and Theory

Published on 31 Mar 2026

Psychedelics and the quantum brain: a falsifiable hypothesis on Posner molecules and spin-dependent pharmacology

in Neuropharmacology

Joseph Geraci
Erik Viirre
Bessi Qorri
Luca Pani

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1777613

582 views

Original Research

Published on 31 Mar 2026

Neuroprotective effects of salidroside against cerebral ischemia-reperfusion injury involve downregulation of total NAMPT and suppression of microglial inflammation

in Neuropharmacology

Meng Zhang
Junchao Xue
Yilin Ping
Huimin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1800667

Original Research

Published on 31 Mar 2026

Efficacy of pregabalin in the treatment of acute cerebral hemorrhage and its influence on prognosis

in Neuropharmacology

Jingchen Li
Shiqi Zhang
Youzhi Ge
Bo Sun
Chen Li
Yunpeng Shi
Xiaopeng Liu
Yuanyu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1774707

2,709 articles

articles

Lycium barbarum glycopeptide Confers Neuroprotection in Chronic Ocular Hypertensive Rats: A Study Investigating Visual Function, Retinal Structure, Microcirculation, and Pyroptosis

Sex-specific behavioral and monoaminergic network alterations following adolescent binge-like ethanol and WIN55,212-2 exposure under chronic nicotine in rats

Flavonoids improve neurotransmitters for Parkinson’s treatment: mechanism and therapeutic potential

Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation

Impact of Valproate Co-medication and Age on Lurasidone Exposure: A Population Pharmacokinetic Study and Real-World Evaluation in Chinese Psychiatric Inpatients

Anxiolytic and Cognitive Effects of Dietary Phenolics in Zebrafish: Rosmarinic Acid, Gallic Acid, and 3-Hydroxytyrosol

Unveiling the neuroprotective effects of pomegranate extract and/or physical activity against aluminum chloride-induced Alzheimer's disease in rats: Modulation of multitude pathways

Employing zebrafish to understand genetic drivers of epilepsy-related comorbid behaviors

Trazodone effectiveness in depression (TED): a comparative evaluation of effect sizes trazodone extended release and SSRIs in the treatment of major depressive disorder

Sex differences in levodopa pharmacokinetics in early Parkinson’s disease: implications on levodopa-related complications

An Integrative Neuropharmacological Review of Huntington's Disease Challenges and the Role of Novel Formulations in Addressing Pharmacological–Pharmaceutical Limitations

Activated glutamatergic neurons in basolateral amygdala suppress nicotine preference behavior in mice

UNDERSTANDING QUANTITATIVE EFFECTS OF ANTI-AMYLOID THERAPIES ON TAU BIOMARKERS AND FUNCTIONAL OUTCOME. INSIGHTS FROM A COMPREHENSIVE MECHANISTIC QUANTITATIVE SYSTEMS PHARMACOLOGY STUDY

Exploring histone acetylation in ischemic stroke: CREBBP and CKAP4 as candidate biomarkers linked to histone acetylation networks

Immune profiling in trigeminal neuralgia reveals altered cytokine and chemokine signatures in cerebrospinal fluid and serum

Akkermansia muciniphila improving depression-like behaviors by regulating glycerophospholipid metabolism in gut-brain axis

Investigating the Therapeutic Mechanism of Puerarin in Vascular Dementia: An Integrated Approach Combining Network Pharmacology and Experimental Validation

Off-label and investigational drugs in the treatment of pathological gambling: A critical review

The immunothrombosis pathway linking pulmonary disease to stroke and neurodegeneration: mechanisms and therapeutic implications

A machine learning model integrating gut microbiota biomarkers for predicting neurological recovery after cerebral hypoxia-ischemia: a single-center study augmented with public data

Remimazolam versus propofol for postoperative ICU sedation in mechanically ventilated cancer patients: a noninferiority randomized clinical trial

Psychedelics and the quantum brain: a falsifiable hypothesis on Posner molecules and spin-dependent pharmacology

Neuroprotective effects of salidroside against cerebral ischemia-reperfusion injury involve downregulation of total NAMPT and suppression of microglial inflammation

Efficacy of pregabalin in the treatment of acute cerebral hemorrhage and its influence on prognosis