Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 03 Nov 2025

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

in Predictive Toxicology

Kristina Jochum
Veronika Städele
Philip Marx-Stoelting

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690384

365 views

Original Research

Accepted on 29 Oct 2025

Predicting tigecycline-related adverse events in Infected patients: A machine learning approach with clinical interpretability

in Predictive Toxicology

Shiya Wu
Yuheng Chen
Wenjie Fan
Xirong Wu
Chaofeng ZHANG
Yuchang Lin
Qi Lin

Frontiers in Pharmacology

133 views

Original Research

Published on 29 Oct 2025

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain

in Predictive Toxicology

Micah Summerlin
Mariano G. Uberti
Dhananjay Shinde
Emma G. Foster
Brady Sillman
Manjeet Kumar
Baojin Yao
Dongming Peng
Benson J. Edagwa
Howard E. Gendelman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681094

387 views

Original Research

Accepted on 27 Oct 2025

Development of cellular models expressing cynomolgus (Macaca fascicularis) HER2 for the functional evaluation of cross-reactive anti-human HER2 response

in Predictive Toxicology

Chiara Cappello
Francesca Ruzzi
Julia Consoli
Maria Sofia Semprini
Laura Scalambra
Olga Maria Pittino
Stefania Angelicola
Arianna Palladini
Mette Thorn
Patrizia Nanni

Frontiers in Pharmacology

153 views

Original Research

Accepted on 23 Oct 2025

Mechanism of Hepatotoxicity Induced by Ethanol Extract of Emilia sonchifolia (L.) DC Revealed by Proteomics and Metabolomics

in Predictive Toxicology

Gongzhen Chen
Qiantonghan Luo
Zicong Song
Ping Zheng
Xin Liu
Ting Tang

Frontiers in Pharmacology

351 views

Original Research

Published on 23 Oct 2025

Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum

in Predictive Toxicology

Yanyi Li
Qi Wang
Yanrong Yang
Xiaobin Huang
Yujie Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666300

458 views

Mini Review

Published on 23 Oct 2025

Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?

in Predictive Toxicology

Li You
Eugenie Nepovimova
Klara Sklenarikova
Qinghua Wu
Kamil Kuca

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700863

433 views

Case Report

Accepted on 20 Oct 2025

A rare case of low-dose methotrexate toxicity leading to skin and mucosal toxicity and invasive pulmonary mucormycosis :a case report

in Predictive Toxicology

Lin Luo
gong Xing Xue
Hui Li
Wang Lei
Xia Xiao Zhao
Na Zhang
Yue Zhang

Frontiers in Pharmacology

Editorial

Published on 20 Oct 2025

Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development

in Predictive Toxicology

Fengxian Zhang
Feiyu Li
Jiaqi Tan
Nan Zhang
Yonglong Han
Jiayu Liao
Huaqiang Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721364

554 views

Original Research

Accepted on 03 Oct 2025

Development and Validation of a Predictive Nomogram for Severe Adverse Drug Reactions: A dual-center Pharmacovigilance Study

in Predictive Toxicology

Wei Bu
Xinjing Wu
Yan Cai

Frontiers in Pharmacology

313 views

Original Research

Published on 01 Oct 2025

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

in Predictive Toxicology

Jianing Bi
Hanzhang Xie
Yixuan Yang
Qiaochu Chen
Bingnan Cui
Zhanshuo Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526836

1,613 views

Original Research

Published on 01 Oct 2025

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

in Predictive Toxicology

Xin Ma
Xiaona He
Yun Wang
Marcin Grzegorzek
Wenjie Long
Hongxi Chen
Fang Gao
Nan Mao
Xinyu Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646948

1,968 views

Opinion

Published on 25 Sep 2025

Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?

in Predictive Toxicology

Vincent Descamps

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681474

1,834 views

Case Report

Published on 24 Sep 2025

MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report

in Predictive Toxicology

Pengfei Liang
Yuncheng Tang
Xiaolin Zhang
Li Zhang
Juan Zhao
Haowen Tang
Zeyu Wu
Qiming Fang
Zhicheng Fang
Zhiwen Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683132

2,341 views
1 citation

Original Research

Published on 17 Sep 2025

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering

in Predictive Toxicology

Qing Lu
Yujie Wu
Dayong Liao
Ying Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615269

2,399 views

Editorial

Published on 16 Sep 2025

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III

in Predictive Toxicology

Alex Boye
Yanzhu Zhu
Xinwei Li
Michel Mansur Machado
Fatma M. El Demerdash
Xu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690145

2,047 views