Frontiers in Pharmacology | Predictive Toxicology

Technology and Code

Published on 01 Dec 2025

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

in Predictive Toxicology

Austin Ross
Vijay Gombar
Alexander Sedykh
Adrian J. Green
Alexandre Borrel
Brian Kidd
Jason Phillips
Mihir Shah
Dhiral Phadke
Deepak Mav

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710864

438 views

General Commentary

Accepted on 28 Nov 2025

Letter to the Editor Regarding 28-Day Oral Chronic Toxicity Study of Arctigenin in Rats

in Predictive Toxicology

Michelle Carnazza
Nan Yang
Jan Geliebter
Raj Tiwari
Xiu-Min Li

Frontiers in Pharmacology

Original Research

Published on 26 Nov 2025

Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats

in Predictive Toxicology

Rajeev Sood
Devesh Tewari
Musarrat Husain Warsi
Anoop Kumar
Shweta Kasna
J. P. Jaiswal
Pranay R. Sakya
Sonam Yoezer
Gaurav K. Jain

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705059

642 views

Original Research

Accepted on 20 Nov 2025

Phoxim Induces Neurotoxicity and Intestinal Damage in Caenorhabditis elegans

in Predictive Toxicology

Mengyuan ZHANG
Xin Zhao
Hua Bai
Qi Wang
Wei Zou

Frontiers in Pharmacology

245 views

Case Report

Published on 20 Nov 2025

Occupational 4-Methylsulfonyl-benzonitrile poisoning: a case report

in Predictive Toxicology

Jianjian Liu
Zhaozhao Shan
Yuru Liu
Yingying Zheng
Xiangdong Jian
Baotian Kan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616964

299 views

Case Report

Published on 19 Nov 2025

A rare case of low-dose methotrexate toxicity leading to skin and mucosal toxicity and invasive pulmonary mucormycosis: a case report

in Predictive Toxicology

Lin Luo
Lei Wang
Xiaoxia Zhao
Na Zhang
Yue Zhang
Xinggong Xue
Hui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704810

447 views

Original Research

Published on 18 Nov 2025

Predicting tigecycline-related adverse events in infected patients: a machine learning approach with clinical interpretability

in Predictive Toxicology

Shiya Wu
Yuheng Chen
Wenjie Fan
Xirong Wu
Chaofeng Zhang
Yucang Lin
Qi Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697929

502 views

Original Research

Accepted on 17 Nov 2025

The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids

in Predictive Toxicology

Rocío Rivera Rodríguez
Siri Sæterstad
Ann-Therese Chattergoon Ali
Linn-Karina M. Selvik
Ingunn Bakke
Torunn Bruland
Jeremy James Johnson

Frontiers in Pharmacology

Original Research

Accepted on 14 Nov 2025

Off-Target Autophagy Disruption Associated with a Novel Liver Toxicity in Dogs for a Highly Basic Heterobifunctional Protein Degrader

in Predictive Toxicology

James E Kath
Rebecca Kohnken
Timothy Brayman
Junhai Yang
Katharina Haag
Jingyi Gong
Christopher Untucht
Christiane Imhof
Kenneth P Robinson
Ryan McClure

Frontiers in Pharmacology

275 views

Original Research

Published on 13 Nov 2025

Development of cellular models expressing cynomolgus (Macaca fascicularis) HER2 for the functional evaluation of cross-reactive anti-human HER2 response

in Predictive Toxicology

Chiara Cappello
Francesca Ruzzi
Julia Consoli
Maria Sofia Semprini
Laura Scalambra
Olga Maria Pittino
Stefania Angelicola
Arianna Palladini
Mette Thorn
Patrizia Nanni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675875

678 views

Original Research

Published on 10 Nov 2025

Mechanism of hepatotoxicity induced by ethanol extract of Emilia sonchifolia (L.) DC revealed by proteomics and metabolomics

in Predictive Toxicology

Gongzhen Chen
Qiantonghan Luo
Zicong Song
Ping Zheng
Xin Liu
Ting Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669607

801 views

Review

Published on 07 Nov 2025

The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis

in Predictive Toxicology

Nyruz Elahmer
Norazlina Mohamed
Sok Kuan Wong
Nur Khadijah Muhamad Jamil
Isa Naina Mohamed
Sabarul Afian Mokhtar
Norliza Muhammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669222

1,545 views

Original Research

Published on 07 Nov 2025

Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study

in Predictive Toxicology

Wei Bu
Xinjing Wu
Chengyu Wang
Yan Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669995

933 views

Original Research

Published on 03 Nov 2025

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

in Predictive Toxicology

Kristina Jochum
Veronika Städele
Philip Marx-Stoelting

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690384

778 views

Original Research

Published on 29 Oct 2025

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain

in Predictive Toxicology

Micah Summerlin
Mariano G. Uberti
Dhananjay Shinde
Emma G. Foster
Brady Sillman
Manjeet Kumar
Baojin Yao
Dongming Peng
Benson J. Edagwa
Howard E. Gendelman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681094

848 views

Mini Review

Published on 23 Oct 2025

Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?

in Predictive Toxicology

Li You
Eugenie Nepovimova
Klara Sklenarikova
Qinghua Wu
Kamil Kuca

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700863

875 views