Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 18 Dec 2025

The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids

in Predictive Toxicology

Rocío Rivera Rodríguez
Siri Sæterstad
Ann-Therese Chattergoon Ali
Linn-Karina M. Selvik
Ingunn Bakke
Torunn Bruland
Jeremy J. Johnson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1696576

304 views

Case Report

Accepted on 10 Dec 2025

Recurrent Hyperammonemic Encephalopathy in a Breast Cancer Patient Receiving Capecitabine Therapy: A Case Report

in Predictive Toxicology

Yuling Mu
Qing Li
Jilin Kong
Yuyao Zhao

Frontiers in Pharmacology

132 views

Original Research

Published on 10 Dec 2025

Off-target autophagy disruption associated with a novel liver toxicity in dogs for a highly basic heterobifunctional protein degrader

in Predictive Toxicology

James E. Kath
Rebecca Kohnken
Timothy Brayman
Junhai Yang
Katharina Haag
Jingyi Gong
Christopher Untucht
Christiane Imhof
Kenneth P. Robinson
Ryan A. McClure

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664889

1,151 views

Original Research

Published on 09 Dec 2025

Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans

in Predictive Toxicology

Mengyuan Zhang
Xin Zhao
Hua Bai
Qi Wang
Wei Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657527

482 views

Technology and Code

Published on 01 Dec 2025

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

in Predictive Toxicology

Austin Ross
Vijay Gombar
Alexander Sedykh
Adrian J. Green
Alexandre Borrel
Brian Kidd
Jason Phillips
Mihir Shah
Dhiral Phadke
Deepak Mav

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710864

764 views

General Commentary

Accepted on 28 Nov 2025

Letter to the Editor Regarding 28-Day Oral Chronic Toxicity Study of Arctigenin in Rats

in Predictive Toxicology

Michelle Carnazza
Nan Yang
Jan Geliebter
Raj Tiwari
Xiu-Min Li

Frontiers in Pharmacology

108 views

Original Research

Published on 26 Nov 2025

Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats

in Predictive Toxicology

Rajeev Sood
Devesh Tewari
Musarrat Husain Warsi
Anoop Kumar
Shweta Kasna
J. P. Jaiswal
Pranay R. Sakya
Sonam Yoezer
Gaurav K. Jain

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705059

925 views

Case Report

Published on 20 Nov 2025

Occupational 4-Methylsulfonyl-benzonitrile poisoning: a case report

in Predictive Toxicology

Jianjian Liu
Zhaozhao Shan
Yuru Liu
Yingying Zheng
Xiangdong Jian
Baotian Kan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616964

512 views

Case Report

Published on 19 Nov 2025

A rare case of low-dose methotrexate toxicity leading to skin and mucosal toxicity and invasive pulmonary mucormycosis: a case report

in Predictive Toxicology

Lin Luo
Lei Wang
Xiaoxia Zhao
Na Zhang
Yue Zhang
Xinggong Xue
Hui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704810

674 views

Original Research

Published on 18 Nov 2025

Predicting tigecycline-related adverse events in infected patients: a machine learning approach with clinical interpretability

in Predictive Toxicology

Shiya Wu
Yuheng Chen
Wenjie Fan
Xirong Wu
Chaofeng Zhang
Yucang Lin
Qi Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697929

808 views

Original Research

Published on 13 Nov 2025

Development of cellular models expressing cynomolgus (Macaca fascicularis) HER2 for the functional evaluation of cross-reactive anti-human HER2 response

in Predictive Toxicology

Chiara Cappello
Francesca Ruzzi
Julia Consoli
Maria Sofia Semprini
Laura Scalambra
Olga Maria Pittino
Stefania Angelicola
Arianna Palladini
Mette Thorn
Patrizia Nanni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675875

871 views

Original Research

Published on 10 Nov 2025

Mechanism of hepatotoxicity induced by ethanol extract of Emilia sonchifolia (L.) DC revealed by proteomics and metabolomics

in Predictive Toxicology

Gongzhen Chen
Qiantonghan Luo
Zicong Song
Ping Zheng
Xin Liu
Ting Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669607

938 views

Review

Published on 07 Nov 2025

The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis

in Predictive Toxicology

Nyruz Elahmer
Norazlina Mohamed
Sok Kuan Wong
Nur Khadijah Muhamad Jamil
Isa Naina Mohamed
Sabarul Afian Mokhtar
Norliza Muhammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669222

1,757 views

Original Research

Published on 07 Nov 2025

Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study

in Predictive Toxicology

Wei Bu
Xinjing Wu
Chengyu Wang
Yan Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669995

1,129 views

Original Research

Published on 03 Nov 2025

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

in Predictive Toxicology

Kristina Jochum
Veronika Städele
Philip Marx-Stoelting

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690384

897 views

Original Research

Published on 29 Oct 2025

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain

in Predictive Toxicology

Micah Summerlin
Mariano G. Uberti
Dhananjay Shinde
Emma G. Foster
Brady Sillman
Manjeet Kumar
Baojin Yao
Dongming Peng
Benson J. Edagwa
Howard E. Gendelman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681094

992 views

Mini Review

Published on 23 Oct 2025

Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?

in Predictive Toxicology

Li You
Eugenie Nepovimova
Klara Sklenarikova
Qinghua Wu
Kamil Kuca

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700863

1,071 views

Original Research

Published on 23 Oct 2025

Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum

in Predictive Toxicology

Yanyi Li
Qi Wang
Yanrong Yang
Xiaobin Huang
Yujie Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666300

772 views

Editorial

Published on 20 Oct 2025

Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development

in Predictive Toxicology

Fengxian Zhang
Feiyu Li
Jiaqi Tan
Nan Zhang
Yonglong Han
Jiayu Liao
Huaqiang Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721364

899 views

Original Research

Published on 01 Oct 2025

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

in Predictive Toxicology

Jianing Bi
Hanzhang Xie
Yixuan Yang
Qiaochu Chen
Bingnan Cui
Zhanshuo Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526836

2,322 views

Original Research

Published on 01 Oct 2025

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

in Predictive Toxicology

Xin Ma
Xiaona He
Yun Wang
Marcin Grzegorzek
Wenjie Long
Hongxi Chen
Fang Gao
Nan Mao
Xinyu Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646948

2,513 views

Opinion

Published on 25 Sep 2025

Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?

in Predictive Toxicology

Vincent Descamps

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681474

2,010 views
1 citation

Case Report

Published on 24 Sep 2025

MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report

in Predictive Toxicology

Pengfei Liang
Yuncheng Tang
Xiaolin Zhang
Li Zhang
Juan Zhao
Haowen Tang
Zeyu Wu
Qiming Fang
Zhicheng Fang
Zhiwen Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683132

2,904 views
1 citation

Original Research

Published on 17 Sep 2025

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering

in Predictive Toxicology

Qing Lu
Yujie Wu
Dayong Liao
Ying Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615269

2,847 views
1 citation

490 articles

articles

The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids

Recurrent Hyperammonemic Encephalopathy in a Breast Cancer Patient Receiving Capecitabine Therapy: A Case Report

Off-target autophagy disruption associated with a novel liver toxicity in dogs for a highly basic heterobifunctional protein degrader

Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

Letter to the Editor Regarding 28-Day Oral Chronic Toxicity Study of Arctigenin in Rats

Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats

Occupational 4-Methylsulfonyl-benzonitrile poisoning: a case report

A rare case of low-dose methotrexate toxicity leading to skin and mucosal toxicity and invasive pulmonary mucormycosis: a case report

Predicting tigecycline-related adverse events in infected patients: a machine learning approach with clinical interpretability

Development of cellular models expressing cynomolgus (Macaca fascicularis) HER2 for the functional evaluation of cross-reactive anti-human HER2 response

Mechanism of hepatotoxicity induced by ethanol extract of Emilia sonchifolia (L.) DC revealed by proteomics and metabolomics

The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis

Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain

Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?

Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum

Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?

MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering