MINI REVIEW article
Front. Psychol.
Sec. Developmental Psychology
Volume 16 - 2025 | doi: 10.3389/fpsyg.2025.1558081
Neurobiological Basis of Autism Spectrum Disorder: mini review
Provisionally accepted
Maria Vanessa Freitas Holanda*
Eva da Silva Paiva
Larissa Nayara de Souza
Karina Maia Paiva
Rodrigo Freire Oliveira
Élyssa Adriolly Freitas Tavares
Paulo Leonardo Araújo de Góis MoraisAriel Moraes de AndradeMaria Irany KnackfussEllany Gurgel Cosme do Nascimento
José Rodolfo Lopes De Paiva Cavalcanti- University of the State of Rio Grande do Norte, Mossoro, Brazil
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Autism Spectrum Disorder is a neuropsychiatric condition characterized by deficits in communication, social interaction, and repetitive behaviors, with significant symptom variability. This multifaceted profile reflects a complex genetic architecture as well as diversity in morphological characteristics. Therefore, the objective of this review is to discuss the genetic and morphological aspects that may contribute to understanding autism. No temporal restrictions were applied for study inclusion, nor were there limitations regarding language. Scientific articles available in full text and directly related to the topic were included, while editorials, letters, conference abstracts, theses, dissertations, and books were excluded. The results of this review converge on two main aspects: (1) genetic and morphological findings are essential for a more comprehensive understanding of the disorder, providing an important basis for investigating its underlying mechanisms; and (2) despite their relevance, the results are still incipient and insufficient to explain the full clinical and behavioral heterogeneity associated with autism, highlighting the need for further studies.
Keywords: Autism spectrum Disorder1, neurobiological bases2, morphological changes3, genetic aspects4, neurodevelopmental disorder5
Received: 09 Jan 2025; Accepted: 15 May 2025.
Copyright: © 2025 Holanda, Paiva, de Souza, Paiva, Oliveira, Tavares, Morais, Andrade, Knackfuss, Nascimento and Cavalcanti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maria Vanessa Freitas Holanda, University of the State of Rio Grande do Norte, Mossoro, Brazil
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.